Abstract:
Methods, systems and apparatus for monochromatic UV light sterilization of liquid and/or solid products/solutions and/or packaging/container systems for liquid and/or solid products/solutions include parenteral pharmaceutical products/solutions and/or packaging/container systems for parenteral pharmaceutical products/solutions Improved systems and methods for the sterilization of container systems and/or container-packaged products include using monochromatic, continuous wave, high-intensity, incoherent light in multiple light source configurations, wherein such sterilization regimen achieves a desired sterilization level without negatively affecting the physical properties of the package/container systems and/or the efficacy of the underlying products/systems.
Abstract:
Methods, systems and apparatus for photo-processing of fluids, particularly complex fluids, such as blood products, pharmaceuticals, injectables and vaccines, are provided. The disclosed methods and systems employ non-laser light source(s) to generate monochromatic light energy, preferably in the range of 260 nm to 310 nm, for fluid treatment. Advantageous processing regimens and/or adjunct additives and/or agents may also be used to achieve desired and/or enhanced results, e.g., inactivation of pathogens, bacteria and/or viruses, modulation of immune response, and/or leukoreduction. Particularly preferred embodiments include novel temperature control systems and geometric/structural arrangements that provide enhanced processing results and/or efficiencies. The disclosed methods, systems and apparatus achieve desirable results in a broad range of diagnostic, therapeutic and treatment applications, and generally provide enhanced operating efficiencies and/or processing results in application modalities that employ a broad range of photo-activated and/or photo-responsive materials and/or compounds.
Abstract:
The apparatus is a gas filled ultraviolet generating lamp (10) for use as a liquid purifier. The lamp (10) is powered by high voltage AC, but has no metallic electrode within or in contact with the gas enclosure which is constructed as two concentric quartz cylinders (16, 20) sealed together at their ends, with the gas fill between the cylinders. Cooling liquid is pumped through the volume (14) inside the inner quartz cylinder (16), where an electrically conductive pipe (12) spaced from the inner cylinder (16) is used to supply the cooling liquid and act as the high voltage electrode. The gas enclosure (18) is enclosed within but spaced from a metal housing (28) which is connected to operate as the ground electrode of the circuit and through which the treated fluid flows. Thus, the electrical circuit is from the central pipe (12), and through the cooling liquid, the gas enclosure (18), the treated liquid on the outside of the outer quartz cylinder (20), and to the housing (28). The high voltage electrode (12) is electrically isolated from the source of cooling liquid by a length of insulated hose which also supplies the cooling liquid.
Abstract:
Packaging materials and containers may be treated with sterilization dosages internally and externally using monochromatic, continuous wave, high-intensity, incoherent light in single and/or multiple light source configurations. The treatment systems and methods preserve physical and performance properties of the packaging/container while achieving a desired level of sterilization. The sterilized materials may be adapted for extended shelf life (ESL) products. The disclosed treatment systems and methods may also be used for sterilization of food and beverage products (either prepackaged or post packaged), medicines, pharmaceuticals, vitamins, infusion products, clinical and/or non-clinical solutions and systems, enteral and/or parenteral solutions and systems, and the like.
Abstract:
The apparatus is a gas filled lamp or electrical discharge assembly for use as a liquid purifier. The lamp is powered by high voltage AC, but has no metallic electrodes within or in contact with the gas enclosure. Cooling liquid is pumped through the volume inside the inner quartz cylinder where an electrically conductive pipe spaced from the inner cylinder is used to supply the cooling liquid and act as a first electrode. The gas enclosure is enclosed within but spaced from a housing which is connected to operate as the second or ground electrode of the circuit and through which the treated fluid flows. The first electrode is electrically isolated from the source of cooling liquid. A method for treating a liquid with a radiation generating lamp is also provided and includes providing a treatment chamber which comprises the first and second electrodes and the gas enclosure containing a gas capable of generating an electrical discharge and positioned between the electrodes.