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1.发明申请
公开(公告)号：WO2007047301A2
公开(公告)日：2007-04-26
申请号：PCT/US2006039711
申请日：2006-10-11
Applicant: SCRIPPS RESEARCH INST , TSAO MENG-LIN , TIAN FENG , SCHULTZ PETER
Inventor： TSAO MENG-LIN , TIAN FENG , SCHULTZ PETER
IPC: C12P21/06
CPC classification number: C12P21/02 , C07K14/005 , C07K2319/00 , C07K2319/50 , C12N7/00 , C12N9/93 , C12N15/1037 , C12N15/67 , C12N2795/14122
Abstract: The invention relates to posttranslational modification of phage-displayed polypeptides. These displayed polypeptides comprise at least one unnatural amino acid, e.g., an aryl-azide amino acid such as p-azido-L-phenylalanine, or an alkynyl-amino acid such as para- propargyloxyphenylalanine, which are incorporated into the phage-displayed fusion polypeptide at a selected position by using an in vivo orthogonal translation system comprising a suitable orthogonal aminoacyl-tRNA synthetase and a suitable orthogonal tRNA species. These unnatural amino acids advantageously provide targets for posttranslational modifications such as azide-alkyne [3+2] cycloaddition reactions and Staudinger modifications.
Abstract translation: 本发明涉及噬菌体展示多肽的翻译后修饰。 这些显示的多肽包含至少一个非天然氨基酸，例如芳基叠氮氨基酸如对叠氮基-L-苯丙氨酸或炔基 - 氨基酸如对羟基羟基苯丙氨酸，其被并入噬菌体展示的融合物 通过使用包含合适的正交氨酰-tRNA合成酶和合适的正交tRNA物质的体内正交翻译系统，在选定位置上的多肽。 这些非天然氨基酸有利地提供翻译后修饰的靶标，例如叠氮炔 - 炔[3 + 2]环加成反应和施陶丁格修饰。
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2.发明申请ORTHOGONAL TRANSLATION COMPONENTS FOR THE IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS 审中-公开正交翻译组件用于体内掺入非天然氨基酸
公开(公告)号：WO2006110182A3
公开(公告)日：2006-12-21
申请号：PCT/US2005039210
申请日：2005-10-27
Applicant: SCRIPPS RESEARCH INST , SCHULTZ PETER , ALFONTA LITAL , CHITTULURU JONATHAN R , DEITERS ALEXANDER , GROFF DAN , SUMMERER DANIEL , TSAO MENG-LIN , WANG JIANGYUN , WU NING , XIE JIANMING , ZENG HUAQIANG
Inventor： SCHULTZ PETER , ALFONTA LITAL , CHITTULURU JONATHAN R , DEITERS ALEXANDER , GROFF DAN , SUMMERER DANIEL , TSAO MENG-LIN , WANG JIANGYUN , WU NING , XIE JIANMING , ZENG HUAQIANG
CPC classification number: C12N9/93 , C12N15/1058 , C12P21/00 , C12P21/02
Abstract: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins produced in eubacterial host cells such as E.coli,or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
Abstract translation: 本发明涉及正交配对的tRNA和氨酰基-tRNA合成酶，其可以将非天然氨基酸并入在真细菌宿主细胞例如大肠杆菌或真核宿主例如酵母细胞中产生的蛋白质中。 本发明提供例如但不限于新颖的正交合成酶，鉴定和制备新型合成酶的方法，生产含有非天然氨基酸的蛋白质的方法和翻译系统。
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公开(公告)号：WO2007047301A3
公开(公告)日：2007-04-26
申请号：PCT/US2006/039711
申请日：2006-10-11
Applicant: THE SCRIPPS RESEARCH INSTITUTE , TSAO, Meng-lin , TIAN, Feng , SCHULTZ, Peter
Inventor： TSAO, Meng-lin , TIAN, Feng , SCHULTZ, Peter
Abstract: The invention relates to posttranslational modification of phage-displayed polypeptides. These displayed polypeptides comprise at least one unnatural amino acid, e.g ., an aryl-azide amino acid such as p -azido-L-phenylalanine, or an alkynyl-amino acid such as para- propargyloxyphenylalanine, which are incorporated into the phage-displayed fusion polypeptide at a selected position by using an in vivo orthogonal translation system comprising a suitable orthogonal aminoacyl-tRNA synthetase and a suitable orthogonal tRNA species. These unnatural amino acids advantageously provide targets for posttranslational modifications such as azide-alkyne [3+2] cycloaddition reactions and Staudinger modifications.
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Patent Agency Ranking4.发明申请BREAKING IMMUNOLOGICAL TOLERANCE WITH A GENETICALLY ENCODED UNNATURAL AMINO ACID 审中-公开用遗传编码的非天然氨基酸突破免疫学公差
公开(公告)号：WO2009099672A2
公开(公告)日：2009-08-13
申请号：PCT/US2009/000813
申请日：2009-02-07
Applicant: THE SCRIPPS RESEARCH INSTITUTE , GRUNEWALD, Jan , TSAO, Meng-Lin , PERERA, Roshan , LERNER, Richard, A. , SMIDER, Vaughn, V. , SCHULTZ, Peter, G.
Inventor： GRUNEWALD, Jan , TSAO, Meng-Lin , PERERA, Roshan , LERNER, Richard, A. , SMIDER, Vaughn, V. , SCHULTZ, Peter, G.
IPC: A61K39/395 , A61K31/19 , A61P37/04 , A61P35/00 , A61P25/28
CPC classification number: C07K16/241 , A61K31/19 , A61K39/0008 , C07K16/44 , Y02A50/491 , Y02A50/492
Abstract: The present invention comprises methods and compositions for producing and/or enhancing an immunological response in a subject against a target moiety such as a disease-related moiety by administration of an antigenic version of the target moiety having one or more unnatural amino acid and/or by administration of an antibody against a version of a target moiety having one or more unnatural amino acid which antibody is cross reactive with the natural target moiety.
Abstract translation: 本发明包括用于通过施用具有一个靶部分的抗原形式来产生和/或增强受试者针对靶部分如疾病相关部分的免疫应答的方法和组合物 或更多非天然氨基酸和/或通过施用针对具有一个或多个非天然氨基酸的形式的靶部分的抗体，所述抗体与天然靶部分交叉反应。
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5.发明申请
公开(公告)号：WO2009061369A2
公开(公告)日：2009-05-14
申请号：PCT/US2008/012363
申请日：2008-10-31
Applicant: THE SCRIPPS RESEARCH INSTITUTE , LIU, Chang , TSAO, Meng-Lin , SMIDER, Vaughn , SCHULTZ, Peter, G.
Inventor： LIU, Chang , TSAO, Meng-Lin , SMIDER, Vaughn , SCHULTZ, Peter, G.
CPC classification number: C12N15/1037 , C12N15/1058 , C12N15/67 , C40B40/08 , C40B40/10
Abstract: The invention provides methods and compositions for screening polypeptide libraries that include variants comprising unnatural amino acids. In addition, the invention provides vector packaging systems and methods for packaging a nucleic acid in a vector. Compositions of vectors produced by the methods and systems are also provided
Abstract translation: 本发明提供了用于筛选包括含有非天然氨基酸的变体的多肽文库的方法和组合物。 另外，本发明提供了用于将核酸包装在载体中的载体包装系统和方法。 也提供了由这些方法和系统产生的载体组合物
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6.发明申请BREAKING IMMUNOLOGICAL TOLERANCE WITH A GENETICALLY ENCODED UNNATURAL AMINO ACID 审中-公开使用遗传编码的UNNATURAL氨基酸破坏免疫力
公开(公告)号：WO2009099672A3
公开(公告)日：2009-11-12
申请号：PCT/US2009000813
申请日：2009-02-07
Applicant: SCRIPPS RESEARCH INST , GRUNEWALD JAN , TSAO MENG-LIN , PERERA ROSHAN , LERNER RICHARD A , SMIDER VAUGHN V , SCHULTZ PETER G
Inventor： GRUNEWALD JAN , TSAO MENG-LIN , PERERA ROSHAN , LERNER RICHARD A , SMIDER VAUGHN V , SCHULTZ PETER G
IPC: A61K39/395 , A61K31/198 , A61P25/28 , A61P35/00 , A61P37/04 , C12P21/02 , C12Q1/68
CPC classification number: C07K16/241 , A61K31/19 , A61K39/0008 , C07K16/44
Abstract: The present invention comprises methods and compositions for producing and/or enhancing an immunological response in a subject against a target moiety such as a disease-related moiety by administration of an antigenic version of the target moiety having one or more unnatural amino acid and/or by administration of an antibody against a version of a target moiety having one or more unnatural amino acid which antibody is cross reactive with the natural target moiety.
Abstract translation: 本发明包括用于通过施用具有一个或多个非天然氨基酸的靶部分的抗原性版本来产生和/或增强受试者中针对靶部分例如疾病相关部分的免疫应答的方法和组合物，和/或 通过施用针对具有一个或多个非天然氨基酸的靶部分版本的抗体，该抗体与天然靶标部分交叉反应。
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7.发明申请
公开(公告)号：WO2009061369A3
公开(公告)日：2009-09-03
申请号：PCT/US2008012363
申请日：2008-10-31
Applicant: SCRIPPS RESEARCH INST , LIU CHANG , TSAO MENG-LIN , SMIDER VAUGHN , SCHULTZ PETER G
Inventor： LIU CHANG , TSAO MENG-LIN , SMIDER VAUGHN , SCHULTZ PETER G
CPC classification number: C12N15/1037 , C12N15/1058 , C12N15/67 , C40B40/08 , C40B40/10
Abstract: The invention provides methods and compositions for screening polypeptide libraries that include variants comprising unnatural amino acids. In addition, the invention provides vector packaging systems and methods for packaging a nucleic acid in a vector. Compositions of vectors produced by the methods and systems are also provided
Abstract translation: 本发明提供了用于筛选多肽文库的方法和组合物，其包括包含非天然氨基酸的变体。 此外，本发明提供了用于在载体中包装核酸的载体包装系统和方法。 还提供了由方法和系统生成的载体的组合物
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8.发明申请ORTHOGONAL TRANSLATION COMPONENTS FOR THE IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDS 审中-公开非营利性翻译组件，用于公民参与联合氨基酸
公开(公告)号：WO2006110182A2
公开(公告)日：2006-10-19
申请号：PCT/US2005/039210
申请日：2005-10-27
Applicant: THE SCRIPPS RESEARCH INSTITUTE , SCHULTZ, Peter , ALFONTA, Lital , CHITTULURU, Jonathan, R. , DEITERS, Alexander , GROFF, Dan , SUMMERER, Daniel , TSAO, Meng-lin , WANG, Jiangyun , WU, Ning , XIE, Jianming , ZENG, Huaqiang
Inventor： SCHULTZ, Peter , ALFONTA, Lital , CHITTULURU, Jonathan, R. , DEITERS, Alexander , GROFF, Dan , SUMMERER, Daniel , TSAO, Meng-lin , WANG, Jiangyun , WU, Ning , XIE, Jianming , ZENG, Huaqiang
CPC classification number: C12N9/93 , C12N15/1058 , C12P21/00 , C12P21/02
Abstract: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins produced in eubacterial host cells such as E.coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
Abstract translation: 本发明涉及tRNA和氨酰-tRNA合成酶的正交对，其可以将非天然氨基酸掺入到在细菌宿主细胞如大肠杆菌或真核宿主如酵母细胞中产生的蛋白质中。 本发明提供了例如但不限于新的正交合成酶，用于鉴定和制备新合成酶的方法，用于产生含有非天然氨基酸的蛋白质的方法和翻译系统。
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