公开(公告)号：EP1915096A4

公开(公告)日：2010-01-13

申请号：EP06847253

申请日：2006-06-15

Applicant: UNIV HEALTH NETWORK ,  KOLIOS MICHEAL ,  CZARNOTA GREGORY J ,  SHERAR MICHAEL D ,  TUNIS ADAM ,  HUNT JOHN W

Inventor： KOLIOS MICHAEL ,  CZARNOTA GREGORY J ,  SHERAR MICHAEL D ,  TUNIS ADAM ,  HUNT JOHN W

IPC: A61B8/00 ,  A61B8/08

CPC classification number: A61B8/08 ,  A61B2090/378 ,  A61F7/00 ,  A61N5/062 ,  A61N5/10

公开(公告)号：EP1915096A2

公开(公告)日：2008-04-30

申请号：EP06847253.9

申请日：2006-06-15

Applicant: University Health Network ,  Kolios, Micheal ,  Czarnota, Gregory J. ,  Sherar, Michael D. ,  Tunis, Adam ,  Hunt, John W.

Inventor： KOLIOS, Michael ,  CZARNOTA, Gregory, J. ,  SHERAR, Michael, D. ,  TUNIS, Adam ,  HUNT, John, W.

IPC: A61B8/00

CPC classification number: A61B8/08 ,  A61B2090/378 ,  A61F7/00 ,  A61N5/062 ,  A61N5/10

Abstract: A method of detecting cellular damage within a subject comprises transmitting low frequency ultrasound (20MHz or below) into a selected site within the subject wherein the selected site has been exposed to a stress capable of causing cellular death at the selected site. At least a portion of ultrasound backscattered from the ultrasound transmitted into the selected site is received. The received backscattered ultrasound is compared to a control backscatter measurement. An increase or a decrease in intensity or spectral slope of the received backscattered ultrasound when compared to the control backscatter measurement indicates cellular death or damage at the selected site within the subject.

公开(公告)号：WO2007063425A2

公开(公告)日：2007-06-07

申请号：PCT/IB2006/003982

申请日：2006-06-15

Applicant: UNIVERSITY HEALTH NETWORK ,  KOLIOS, Michael ,  CZARNOTA, Gregory, J. ,  SHERAR, Michael, D. ,  TUNIS, Adam ,  HUNT, John, W.

Inventor： KOLIOS, Michael ,  CZARNOTA, Gregory, J. ,  SHERAR, Michael, D. ,  TUNIS, Adam ,  HUNT, John, W.

CPC classification number: A61B8/08 ,  A61B2090/378 ,  A61F7/00 ,  A61N5/062 ,  A61N5/10

Abstract: A method of detecting cellular damage within a subject comprises transmitting low frequency ultrasound (20MHz or below) into a selected site within the subject wherein the selected site has been exposed to a stress capable of causing cellular death at the selected site. At least a portion of ultrasound backscattered from the ultrasound transmitted into the selected site is received. The received backscattered ultrasound is compared to a control backscatter measurement. An increase or a decrease in intensity or spectral slope of the received backscattered ultrasound when compared to the control backscatter measurement indicates cellular death or damage at the selected site within the subject.

Abstract translation: 检测受试者体内细胞损伤的方法包括将低频超声波（20MHz或以下）发射到受试体内的选定部位，其中所选部位已暴露于能够导致细胞在 选定的网站。 接收从发送到所选位置的超声波反向散射的超声的至少一部分。 将接收到的背散射超声与控制后向散射测量进行比较。 与对照反向散射测量值相比，所接收的反向散射超声波的强度或谱斜率的增加或减少指示受试者内选定部位的细胞死亡或损伤。

公开(公告)号：WO2007063425A3

公开(公告)日：2007-11-08

申请号：PCT/IB2006003982

申请日：2006-06-15

Applicant: UNIV HEALTH NETWORK ,  KOLIOS MICHAEL ,  CZARNOTA GREGORY J ,  SHERAR MICHAEL D ,  TUNIS ADAM ,  HUNT JOHN W

Inventor： KOLIOS MICHAEL ,  CZARNOTA GREGORY J ,  SHERAR MICHAEL D ,  TUNIS ADAM ,  HUNT JOHN W

IPC: A61B8/00 ,  A61B8/08

CPC classification number: A61B8/08 ,  A61B2090/378 ,  A61F7/00 ,  A61N5/062 ,  A61N5/10

Abstract: A method of detecting cellular damage within a subject comprises transmitting low frequency ultrasound (20MHz or below) into a selected site within the subject wherein the selected site has been exposed to a stress capable of causing cellular death at the selected site. At least a portion of ultrasound backscattered from the ultrasound transmitted into the selected site is received. The received backscattered ultrasound is compared to a control backscatter measurement. An increase or a decrease in intensity or spectral slope of the received backscattered ultrasound when compared to the control backscatter measurement indicates cellular death or damage at the selected site within the subject.

Abstract translation: 检测受试者内的细胞损伤的方法包括将低频超声波（20MHz或更低）发送到受试者内的选定部位，其中所选择的部位已暴露于能够在所选位点引起细胞死亡的应激。 从被发送到所选位置的超声波向后散射的超声波的至少一部分被接收。 将接收的反向散射超声波与控制反向散射测量进行比较。 与控制反向散射测量相比，接收的反向散射超声的强度或光谱斜率的增加或减小表明在受试者内的选定部位处的细胞死亡或损伤。