公开(公告)号：JP2006340731A

公开(公告)日：2006-12-21

申请号：JP2006232863

申请日：2006-08-29

Applicant: UNIV SASKATCHEWAN

Inventor： BABIUK LORNE A ,  TIKOO SURESH KUMAR ,  REDDY POLICE SESHIDAR

IPC: C12N15/09 ,  A61K31/711 ,  A61K35/76 ,  A61K38/00 ,  A61K38/22 ,  A61K38/43 ,  A61K38/44 ,  A61K38/46 ,  A61K39/00 ,  A61K48/00 ,  A61P31/00 ,  A61P37/04 ,  C07K14/075 ,  C07K16/08 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N7/00 ,  C12N7/01 ,  C12N7/02 ,  C12N15/861 ,  C12P21/02 ,  C12Q1/68 ,  C12R1/19 ,  C12R1/91 ,  C12R1/93

Abstract: PROBLEM TO BE SOLVED: To provide polypeptides useful for gene therapy purposes. SOLUTION: A method for constructing a recombinant BAV vector containing a heterologous nucleotide sequence inserted into an insertion site, the method comprising: (a) linking the heterologous nucleotide sequence to sequences which have at least 90% identity to a BAV genome sequence comprising a specific sequence surrounding the insertion site, to form an insertion cassette; wherein the insertion site is located in E3 region; (b) introducing the insertion cassette into a cell, along with a second polynucleotide comprising a sequence having at least 90% identity to a BAV genome comprising a specific nucleotide sequence, wherein whole or a part of the E3 region is deleted; and (c) allowing homologous recombination to occur between the insertion cassette and the polynucleotide to generate the recombinant BAV vector. COPYRIGHT: (C)2007,JPO&INPIT

公开(公告)号：CA2129843A1

公开(公告)日：1993-08-19

申请号：CA2129843

申请日：1993-02-10

Applicant: UNIV SASKATCHEWAN ,  UNIV SASKATCHEWAN

Inventor： SCHOENAU JEFFREY J ,  HUANG WEIZE

IPC: G01N1/08 ,  G01N30/00 ,  G01N30/02 ,  G01N30/06 ,  G01N33/24 ,  G01N33/483 ,  G01N33/84 ,  B01J43/00 ,  G01N1/02 ,  G01N33/48

Abstract: 2129843 9316382 PCTABS00025 The invention relates to a kit for the measurement of anion, cation or zwitterion availability in a medium or for the measurement of free inorganic ions in disrupted cells from plant or animal tissue. The kit comprises ion-exchange material having a measurable ion uptake potential for immobilizing available ions from the medium on the material following contact on the material with the medium or suspension. It also comprises means to remove particulate solids from the material after having contacted the medium with the material. Preferably, the ion-exchange material is cation and/or anion-exchange material in the form of rigid or flexible films, sheets, membranes or the like. The invention also relates to a method for the on-site in situ measurement of anion and/or cation availability in a solid medium and to a method for measuring free organic ions in cells from plant or animal tissue. It also relates to ion-exchange material for immobilizing available ions in soil, sediment or water media and to a cation and/or anion-exchange membrane buried underneath the surface of a soil sample or site, the membrane being in ion-exchange relationship with available ions in the soil. The present invention represents an improvement over the prior art in that it provides means for quickly determining ion availability in a particular media without the necessity of collecting media samples for laboratory testing.

公开(公告)号：ES2376817T3

公开(公告)日：2012-03-20

申请号：ES00960628

申请日：2000-08-28

Applicant: MERIAL SAS ,  UNIV SASKATCHEWAN ,  UNIV BELFAST ,  UNIV SASKATCHEWAN ,  UNIV BELFAST

Inventor： ELLIS JOHN ALBERT ,  ALLAN GORDON ,  MEEHAN BRIAN ,  CLARK EDWARD ,  HAINES DEBORAH ,  HASSARD LORI ,  HARDING JOHN ,  CHARREYRE CATHERINE ,  CHAPPUIS GILLES ,  KRAKOWKA GEORGE ,  AUDONNET JEAN-CHRISTOPHE ,  MCNEILLY FRANCIS

IPC: C12N15/09 ,  C12N15/34 ,  A61K35/76 ,  A61K39/00 ,  A61K39/12 ,  A61K48/00 ,  A61P9/00 ,  A61P15/00 ,  A61P15/06 ,  A61P43/00 ,  C07K14/01 ,  C12N7/00 ,  C12Q1/68

Abstract: Un primer vector de plásmido de ADN que comprende una primera secuencia de nucleótidos que tiene al menos el 95% de identidad con ORF13 de cepa Imp1010 de PCV-2, para su uso en la reducción de la carga viral de PCV-2 en los ganglios bronquiales y mesentéricos de un cerdo.

公开(公告)号：NZ621037A

公开(公告)日：2016-02-26

申请号：NZ62103712

申请日：2012-07-13

Applicant: NAT RES COUNCIL CANADA ,  UNIV SASKATCHEWAN ,  UNIV SASKATCHEWAN

Inventor： PAGE JONATHAN E ,  STOUT JASON M

IPC: C12N15/52 ,  C12N9/00 ,  C12N15/29 ,  C12N15/63 ,  C12P17/06 ,  C12P19/32

Abstract: Discloses polypeptides having alkanoyl-CoA activity, nucleic acids encoding the same, and methods relating to altering levels or synthesising cannabinoid compounds in an organism, cell or tissue.

公开(公告)号：WO2005039642A9

公开(公告)日：2005-09-29

申请号：PCT/CA2004001870

申请日：2004-10-25

Applicant: UNIV SASKATCHEWAN ,  FOLDVARI MARIANNA ,  VERRALL RONALD E ,  BADEA ILDIKO

Inventor： FOLDVARI MARIANNA ,  VERRALL RONALD E ,  BADEA ILDIKO

IPC: A61K9/00 ,  A61K9/107 ,  A61K9/127 ,  A61K31/7088 ,  A61K38/21 ,  A61K48/00 ,  C12N15/88 ,  A61K9/06 ,  A61K47/44 ,  A61P17/00

CPC classification number: A61K9/1272 ,  A61K9/0014 ,  A61K9/1075 ,  A61K31/7088 ,  A61K38/217 ,  A61K48/0033 ,  A61K48/0075 ,  C12N15/88

Abstract: The invention provides a delivery system for a biologically active agent comprising a gemini surfactant in admixture with the biologically active agent in a topical formulation for treatment of skin disorders or metabolic diseases. The invention also provides pharmaceutical compositions in topical formulations comprising the delivery system as set out above, in admixture with pharmaceutically acceptable carriers, diluents, excipients, or supplements suitable for application to the skin or mucosal membrane. Methods of preparation and use are also described.

Abstract translation: 本发明提供了一种用于生物活性剂的递送系统，其包含与用于治疗皮肤病症或代谢疾病的局部制剂中的生物活性剂混合的双子表面活性剂。 本发明还提供包含上述递送系统的局部制剂中的药物组合物，其与药学上可接受的载体，稀释剂，赋形剂或适用于皮肤或粘膜的补充剂的混合物。 还描述了制备和使用的方法。

公开(公告)号：WO2005039642B1

公开(公告)日：2005-06-16

申请号：PCT/CA2004001870

申请日：2004-10-25

Applicant: UNIV SASKATCHEWAN ,  FOLDVARI MARIANNA ,  VERRALL RONALD E ,  BADEA ILDIKO

Inventor： FOLDVARI MARIANNA ,  VERRALL RONALD E ,  BADEA ILDIKO

IPC: A61K9/00 ,  A61K9/107 ,  A61K9/127 ,  A61K31/7088 ,  A61K38/21 ,  A61K48/00 ,  C12N15/88 ,  A61K9/06 ,  A61K47/44 ,  A61P17/00

CPC classification number: A61K9/1272 ,  A61K9/0014 ,  A61K9/1075 ,  A61K31/7088 ,  A61K38/217 ,  A61K48/0033 ,  A61K48/0075 ,  C12N15/88

Abstract: The invention provides a delivery system for a biologically active agent comprising a gemini surfactant in admixture with the biologically active agent in a topical formulation for treatment of skin disorders or metabolic diseases. The invention also provides pharmaceutical compositions in topical formulations comprising the delivery system as set out above, in admixture with pharmaceutically acceptable carriers, diluents, excipients, or supplements suitable for application to the skin or mucosal membrane. Methods of preparation and use are also described.

Abstract translation: 本发明提供了用于生物活性剂的递送系统，其包含与用于治疗皮肤病或代谢疾病的局部制剂中的生物活性剂混合的双子表面活性剂。 本发明还提供了局部制剂中的药物组合物，其包含如上所述的递送系统，与可药用载体，稀释剂，赋形剂或适用于皮肤或粘膜的补充物混合。 还描述了制备和使用的方法。

公开(公告)号：WO2004108755A3

公开(公告)日：2005-05-19

申请号：PCT/IB2004002532

申请日：2004-06-10

Applicant: UNIV SASKATCHEWAN ,  TIKOO SURESH K ,  ZAKHARTCHOUK ALEXANDRE N ,  BABIUK LORNE A ,  KAUSHIK RADHEY S ,  GRIEBEL PHILIP J

Inventor： TIKOO SURESH K ,  ZAKHARTCHOUK ALEXANDRE N ,  BABIUK LORNE A ,  KAUSHIK RADHEY S ,  GRIEBEL PHILIP J

IPC: C07K14/075 ,  C12N15/861 ,  C12Q1/70

CPC classification number: C07K14/005 ,  C07K2319/33 ,  C12N2710/10322 ,  C12N2810/405 ,  C12N2810/859

Abstract: The present invention relates to chimeric adenovirus capsid proteins comprising a part of or all of an adenovirus capsid protein and a binding partner of a cell-surface binding site on a cell present in gut associated lymphoid tissues (GALT) of a mammal, wherein the chimeric adenovirus capsid protein is capable of binding the cell present in gut associated lymphoid tissues (GALT). In some examples, the adenovirus capsid protein is located on the surface of the adenovirus capsid. The present invention provides adenovirus capsids comprising a chimeric capsid protein. The present invention also provides complexes comprising a chimeric adenovirus capsid protein bound to a cell in GALT. The present invention also provides encapsidation systems and vectors, in particular adenovirus vectors, capable of expressing a chimeric adenovirus capsid protein encompassed within the invention. The present invention also provides viral particles, host cells and compositions comprising such vectors, in particular for use in vaccines, methods of eliciting an immune response and methods for targeted delivery of heterologous proteins, such as antigens, to target cells.

Abstract translation: 本发明涉及包含哺乳动物肠道相关淋巴组织（GALT）中存在的细胞上的一部分或全部腺病毒衣壳蛋白和细胞表面结合位点的结合配偶体的嵌合腺病毒衣壳蛋白，其中嵌合 腺病毒衣壳蛋白能够结合存在于肠道相关淋巴组织（GALT）中的细胞。 在一些实例中，腺病毒衣壳蛋白位于腺病毒衣壳的表面上。 本发明提供了包含嵌合衣壳蛋白的腺病毒衣壳。 本发明还提供了包含与GALT中的细胞结合的嵌合腺病毒衣壳蛋白的复合物。 本发明还提供能够表达包含在本发明内的嵌合腺病毒衣壳蛋白的包衣系统和载体，特别是腺病毒载体。 本发明还提供病毒颗粒，宿主细胞和包含这种载体的组合物，特别是用于疫苗，引发免疫应答的方法和用于将异源蛋白质例如抗原靶向递送至靶细胞的方法。

公开(公告)号：WO2004108939A2

公开(公告)日：2004-12-16

申请号：PCT/IB2004002409

申请日：2004-06-10

Applicant: UNIV SASKATCHEWAN ,  TIKOO SURESH K ,  XING LI

Inventor： TIKOO SURESH K ,  XING LI

IPC: A61K39/23 ,  A61K39/235 ,  A61K48/00 ,  C07K14/075 ,  C12N7/00 ,  C12N7/04 ,  C12N15/861 ,  C12Q1/70

CPC classification number: C12N15/86 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/10322 ,  C12N2710/10323 ,  C12N2710/10343

Abstract: The present invention relates to the identification of bovine adenovirus sequence(s) essential for encapsidation and El transcriptional control regions. The present invention provides adenovirus expression systems, host cells and compositions comprising adenovirus vectors which comprise one or more BAV sequence(s) essential for encapsidation, as well as helper virus which express BAV sequences essential for encapsidation. The present invention also provides helper vectors comprising uBAV sequence essential for encapsidation which is used in a helper virus for propagating recombinant adenovirus. The present invention also provides adenovirus expression systems, host cells and compositions comprising adenovirus vectors which comprise modifications BAV EI transcriptional control regions. The present inventionalso provides methods for making adenovirus vectors comprising BAV sequence(s) essential for encapsidation as well as modifications BAV El transcriptional control regions.

Abstract translation: 本发明涉及鉴定用于壳化和E1转录控制区必需的牛腺病毒序列。 本发明提供腺病毒表达系统，宿主细胞和包含腺病毒载体的组合物，其包含一个或多个用于包囊所必需的BAV序列，以及表达对于壳化所必需的BAV序列的辅助病毒。 本发明还提供了辅助载体，其包含在辅助病毒中用于繁殖重组腺病毒的用于壳化的uBAV序列。 本发明还提供腺病毒表达系统，宿主细胞和包含腺病毒载体的组合物，其包含修饰BAV EI转录控制区。 本发明还提供了制备包含对于壳化所必需的BAV序列以及修饰BAV E1转录控制区的腺病毒载体的方法。

公开(公告)号：WO0187083A2

公开(公告)日：2001-11-22

申请号：PCT/CA0100693

申请日：2001-05-14

Applicant: UNIV SASKATCHEWAN ,  MAENZ DAVID D ,  NEWKIRK REX W ,  CLASSEN HENRY L ,  TYLER ROBERT T

Inventor： MAENZ DAVID D ,  NEWKIRK REX W ,  CLASSEN HENRY L ,  TYLER ROBERT T

IPC: A23J1/14 ,  A23J3/14 ,  A23K1/14 ,  A23K1/16 ,  A23K1/18 ,  A23L1/211

CPC classification number: C12Y301/03026 ,  A23J1/148 ,  A23J3/14 ,  A23K10/30 ,  A23K20/147 ,  A23K50/00 ,  A23K50/10 ,  A23L11/33

Abstract: The present invention relates to a process for the aqueous extraction, fractionation and enzymatic treatment of oilseed materials to generate valued products with no significant low value by-product or waste streams. In particular, the fractionation scheme generates a protein-fibre feed ingredient principally for use with ruminant animals and a second dephytinized high protein fraction. The dephytinized high protein fraction has value as feed ingredient for a variety of species of animals.

Abstract translation: 本发明涉及一种用于水油提取，分馏和酶处理油籽材料以产生没有显着的低价值副产物或废物流的有价值产品的方法。 特别地，分馏方案产生主要用于反刍动物的蛋白质 - 纤维进料成分和第二脱氢化高蛋白质级分。 脱蛋白的高蛋白质部分具有作为各种动物的饲料成分的价值。

公开(公告)号：WO9821966A2

公开(公告)日：1998-05-28

申请号：PCT/US9721244

申请日：1997-11-18

Applicant: AGRAQUEST INC ,  UNIV SASKATCHEWAN ,  MARRONE PAMELA GAIL ,  MANKER DENISE C ,  HEINS SHERRY D ,  JIMENEZ DESMOND R ,  GERMIDA JAMES J

Inventor： MARRONE PAMELA GAIL ,  MANKER DENISE C ,  HEINS SHERRY D ,  JIMENEZ DESMOND R ,  GERMIDA JAMES J

IPC: C12N1/20 ,  A01N63/00 ,  A01N63/02 ,  A61K9/08 ,  A61K9/16 ,  A61K9/50 ,  A61K35/74 ,  A61P33/00 ,  C12R1/07

CPC classification number: C12R1/07 ,  A01N63/00 ,  A01N63/02 ,  Y10S435/832

Abstract: The present invention relates to a newly discovered Bacillus sp. strain which exhibits pesticidal activity. The supernatant of cultures of this novel isolate are also effective pesticidal agents. Also provided are methods of using the novel strain or supernatant for treatment or prevention of disease in plants or animals.

Abstract translation: 本发明涉及新发现的芽孢杆菌属 具有杀虫活性的菌株。 这种新型分离物的培养物上清也是有效的杀虫剂。 还提供了使用新型菌株或上清液来治疗或预防植物或动物疾病的方法。