公开(公告)号：WO2011022596A3

公开(公告)日：2011-02-24

申请号：PCT/US2010/046091

申请日：2010-08-20

Applicant: DR. REDDY'S LABORATORIES LTD. ,  DR. REDDY'S LABORATORIES, INC. ,  BANDICHHOR, Rakeshwar ,  LEKKALA, Amarnath Reddy ,  HALDAR, Pranab ,  MYLAVARAPU, Ravi Kumar ,  GOLLA, China Malakondaiah ,  VAGWALA, Raghunath ,  KARRI, Vijaya Kumar ,  AKULA, Swapna

Inventor： BANDICHHOR, Rakeshwar ,  LEKKALA, Amarnath Reddy ,  HALDAR, Pranab ,  MYLAVARAPU, Ravi Kumar ,  GOLLA, China Malakondaiah ,  VAGWALA, Raghunath ,  KARRI, Vijaya Kumar ,  AKULA, Swapna

IPC: C07D403/12 ,  C07D403/10 ,  A61K31/55 ,  A61K31/404 ,  A61P5/30

Abstract: Processes for preparing bazedoxifene and its pharmaceutically acceptable salts, substantially free from process related impurities and process intermediates.

公开(公告)号：WO2011022596A2

公开(公告)日：2011-02-24

申请号：PCT/US2010046091

申请日：2010-08-20

Applicant: REDDYS LAB LTD DR ,  REDDYS LAB INC DR ,  BANDICHHOR RAKESHWAR ,  LEKKALA AMARNATH REDDY ,  HALDAR PRANAB ,  MYLAVARAPU RAVI KUMAR ,  GOLLA CHINA MALAKONDAIAH ,  VAGWALA RAGHUNATH ,  KARRI VIJAYA KUMAR ,  AKULA SWAPNA

Inventor： BANDICHHOR RAKESHWAR ,  LEKKALA AMARNATH REDDY ,  HALDAR PRANAB ,  MYLAVARAPU RAVI KUMAR ,  GOLLA CHINA MALAKONDAIAH ,  VAGWALA RAGHUNATH ,  KARRI VIJAYA KUMAR ,  AKULA SWAPNA

IPC: C07D403/12 ,  A61K31/404 ,  A61K31/55 ,  A61P5/30 ,  C07D403/10

CPC classification number: C07D403/12 ,  A61K31/404 ,  A61K31/55

Abstract: Processes for preparing bazedoxifene and its pharmaceutically acceptable salts, substantially free from process related impurities and process intermediates.

Abstract translation: 用于制备基本上不含过程相关杂质和过程中间体的巴多昔芬及其药学上可接受的盐的方法。

公开(公告)号：US09212172B2

公开(公告)日：2015-12-15

申请号：US13822519

申请日：2011-09-14

Applicant: Sundra Lakshmi Kanniah ,  Rajesham Boge ,  Peddireddy Subbareddy ,  Lalita Kanwar ,  Srividya Ramakrishnan ,  Ramya Kumar ,  Rakeshwar Bandichhor ,  Amarnath Reddy Lekkala ,  Ravi Kumar Mylavarapu ,  Vagwala Raghunath

Inventor： Sundra Lakshmi Kanniah ,  Rajesham Boge ,  Peddireddy Subbareddy ,  Lalita Kanwar ,  Srividya Ramakrishnan ,  Ramya Kumar ,  Rakeshwar Bandichhor ,  Amarnath Reddy Lekkala ,  Ravi Kumar Mylavarapu ,  Vagwala Raghunath

IPC: C07D403/10 ,  C07D403/12 ,  C07D209/12

CPC classification number: C07D403/12 ,  C07D209/12

Abstract: Aspects of the present disclosure include crystalline bazedoxifene free base, crystalline bazedoxifene acetate Form D, and processes for their preparation. The drug compound having the adopted name “bazedoxifene acetate” has a chemical name 1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetic acid, and has the chemical structure shown below as Formula I.

Abstract translation: 本公开内容的方面包括结晶巴西多昔芬游离碱，结晶乙酸巴多昔芬乙酸酯形式D及其制备方法。 具有采用的名称为“醋酸巴多昔芬”的药物化合物具有化学名称1- [4-（2-氮杂环庚烷-1-基 - 乙氧基）苄基] -2-（4-羟基苯基）-3-甲基-1H-吲哚-2-基） 5-醇乙酸，具有如下式I所示的化学结构。

公开(公告)号：US20130225805A1

公开(公告)日：2013-08-29

申请号：US13822519

申请日：2011-09-14

Applicant: Sundra Lakshmi Kanniah ,  Rajesham Boge ,  Peddireddy Subbareddy ,  Lalita Kanwar ,  Srividya Ramakrishnan ,  Ramya Kumar ,  Rakeshwar Bandichhor ,  Amarnath Reddy Lekkala ,  Ravi Kumar Mylavarapu ,  Vagwala Raghunath

Inventor： Sundra Lakshmi Kanniah ,  Rajesham Boge ,  Peddireddy Subbareddy ,  Lalita Kanwar ,  Srividya Ramakrishnan ,  Ramya Kumar ,  Rakeshwar Bandichhor ,  Amarnath Reddy Lekkala ,  Ravi Kumar Mylavarapu ,  Vagwala Raghunath

IPC: C07D403/12

CPC classification number: C07D403/12 ,  C07D209/12

Abstract: Aspects of the present disclosure include crystalline bazedoxifene free base, crystalline bazedoxifene acetate Form D, and processes for their preparation. The drug compound having the adopted name “bazedoxifene acetate” has a chemical name 1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetic acid, and has the chemical structure shown below as Formula I.

Abstract translation: 本公开内容的方面包括结晶巴西多昔芬游离碱，结晶乙酸巴多昔芬乙酸酯形式D及其制备方法。 具有采用的名称为“醋酸巴多昔芬”的药物化合物具有化学名称1- [4-（2-氮杂环庚烷-1-基 - 乙氧基）苄基] -2-（4-羟基苯基）-3-甲基-1H-吲哚-2-基） 5-醇乙酸，其化学结构如式I所示。