公开(公告)号：KR1020090055948A

公开(公告)日：2009-06-03

申请号：KR1020070122843

申请日：2007-11-29

Applicant: (주)씨앤팜

Inventor： 강문식 ,  이윤주 ,  최진호 ,  김동윤

IPC: C07F19/00 ,  C07F3/02 ,  C07F5/06 ,  C07F3/00

CPC classification number: A61K8/27 ,  A61K8/37 ,  A61K31/215 ,  A61K33/30

Abstract: A hybrid with layered metal hydroxide is provided to increase the stability of unsaturated fatty acid, easily formulate, and efficiently apply the unsaturated fatty acid into the skin. A hybrid of an undsaturated fatty acid and layered metal hydroxide is obtained by introduction of unsaturated fatty acid between the layers of layered metal hydroxide and hybridization. The metal double layer hydroxide is a compound of the chemical formula 1([M(II)1-xM(III)x(OH)2]X+(An-)X/n.yH2O) or formula 2([M(II)(OH)x'](A)(2-x')/n.yH2O). The hybrid is reformed with tocopherol, lauric acid, tetra-ethyl orthosilicate (TEOS), glyceryl monostearate (GMS) or dimethicone. The method for manufacturing the hybrid comprises: a step of producing essential fatty acid and bivalent metal salt solution; and a step of adding base to adjust to pH 4-8 and collecting the precipitate.

Abstract translation: 提供了层状金属氢氧化物的混合物，以增加不饱和脂肪酸的稳定性，容易配制，并有效地将不饱和脂肪酸施用于皮肤。 通过在层状金属氢氧化物层之间引入不饱和脂肪酸和杂交获得不饱和脂肪酸和层状金属氢氧化物的杂化物。 金属双层氢氧化物是化学式1（[M（II）1-xM（III）x（OH）2] X +（An-）X / n.yH 2 O）或式2（[M（II ）（OH）X ']（A）（2-X'）/ n.yH2O）。 用生育酚，月桂酸，原硅酸四乙酯（TEOS），单硬脂酸甘油酯（GMS）或聚二甲基硅氧烷改性混合物。 制造杂化物的方法包括：生产必需脂肪酸和二价金属盐溶液的步骤; 以及添加碱以调节至pH 4-8并收集沉淀物的步骤。

公开(公告)号：KR100998354B1

公开(公告)日：2010-12-03

申请号：KR1020070122843

申请日：2007-11-29

Applicant: (주)씨앤팜

Inventor： 강문식 ,  이윤주 ,  최진호 ,  김동윤

IPC: C07F19/00 ,  C07F3/02 ,  C07F5/06 ,  C07F3/00

Abstract: 본 발명은 불포화 지방산의 층상형 금속 수산화물과의 혼성체에 관한 것으로, 보다 구체적으로는 불포화 지방산의 안정성을 증가시키면서 다양한 용매 및 제형에서 분산성이 뛰어나 제제화가 용이한 불포화 지방산의 층상형 금속 수산화물과의 혼성체, 그 제조방법, 및 그 혼성체를 포함하는 피부 외용제 및 기능성 식품에 관한 것이다.
불포화 지방산, 필수 지방산, 층상형 금속 수산화물, 혼성체

公开(公告)号：KR1020090102996A

公开(公告)日：2009-10-01

申请号：KR1020080028305

申请日：2008-03-27

Applicant: (주)씨앤팜

Inventor： 강문식

IPC: A61K31/505 ,  A61P35/00

CPC classification number: A61K31/519 ,  A61K47/52 ,  A61K2121/00

Abstract: PURPOSE: An in vivo selective tumor suppressing method using layered dihydroxide is provided to selectively transfer anti-cancer drug to cancer tissue and prevent reduction of efficiency. CONSTITUTION: An in vivo selective tumor suppressing method using layered dihydroxide is performed by transferring to cancer cells and increasing residence time in the body compared with administering anti-cancer drug only. A composition of LDH and anti-cancer drug has targeting function of effectively treating cancer without any side effect. The cancer is osteosarcoma. The composite of the LDH and anti-cancer drug is manufactured in 50-450 nm by hydrothermal reaction.

Abstract translation: 目的：提供使用层状二氧化物的体内选择性肿瘤抑制方法，以选择性地将抗癌药物转移至癌组织，并防止效率降低。 构成：与仅施用抗癌药物相比，使用层状二氢氧化物的体内选择性肿瘤抑制方法通过转移到癌细胞并增加在体内的停留时间来进行。 LDH和抗癌药物的组合物具有有效治疗癌症的靶向功能，无任何副作用。 癌症是骨肉瘤。 LDH和抗癌药物的复合物通过水热反应在50-450nm制备。