公开(公告)号：KR101083419B1

公开(公告)日：2011-11-14

申请号：KR1020090036226

申请日：2009-04-24

Applicant: (주)씨앤팜

Inventor： 손연수 ,  전용주 ,  최성모

IPC: C07F9/22 ,  C07F9/659 ,  A61K47/16

CPC classification number: A61K47/24 ,  A61K9/0024 ,  C07F9/65815

Abstract: 본발명에따른화합물은매우낮은농도 2 w/w% 미만에서도경력한수화겔을형성할수 있다. 또한, 그로부터제조된수화겔은생분해성및 온도감응성을가지고, 제조가간편하며, 단백질을불활성화시키지않고, 약물의다량방출효과없이서방성을나타내므로, 약물, 특히단백질약물의서방성전달을위한약물전달체로서유용하게사용될수 있다.

公开(公告)号：KR1020090113772A

公开(公告)日：2009-11-02

申请号：KR1020090036226

申请日：2009-04-24

Applicant: (주)씨앤팜

Inventor： 손연수 ,  전용주 ,  최성모

IPC: C07F9/22 ,  C07F9/659 ,  A61K47/16

CPC classification number: A61K47/24 ,  A61K9/0024 ,  C07F9/65815

Abstract: PURPOSE: A dendritic oligopeptide-grafted cyclotriphosphazene is provided to form hydrogel in low concentration and use as a drug carrier for transfer a protein drug. CONSTITUTION: A drug carrier with sustained release to drug contains dendritic oligopeptide-grafted cyclotriphosphazene of the chemical formula 1. The drug carrier is used for delivering protein drug or peptide drug. A method for preparing the dendritic oligopeptide-grafted cyclotriphosphazene comprises a step of reacting cyclotriphosphazene containing chlorine and polyethyleneglycol of the chemical formula 5 with ester of branched tetrapeptide of the chemical formula 6.

Abstract translation: 目的：提供树突寡聚肽接枝的环三磷腈以形成低浓度的水凝胶，并用作转运蛋白质药物的药物载体。 构成：具有药物持续释放的药物载体含有化学式1的树突寡聚肽接枝的环三磷腈。药物载体用于递送蛋白质药物或肽药物。 制备树枝状寡肽接枝的环三磷腈的方法包括使化学式5的含氯和聚乙二醇的环三磷腈与化学式6的支链四肽的酯反应的步骤。