公开(公告)号：KR1020030041433A

公开(公告)日：2003-05-27

申请号：KR1020010072226

申请日：2001-11-20

Applicant: (주)아모레퍼시픽

Inventor： 이영대 ,  김정주 ,  김중수 ,  이옥섭

IPC: A61K31/198

Abstract: PURPOSE: A composition for transdermal administration comprising L-arginine which has excellent therapeutic effect and presents no adverse effects even when administered in excess as a main drug is provided. The composition is an external application which overcomes the defects of conventional injections or oral therapeutic agents and effective in treatment of erectile dysfunction and frigidity. CONSTITUTION: A preparation for transdermal administration contains 1 to 20% by weight of L-arginine, 1 to 30% by weight of a skin permeation enhancer, a pharmaceutically acceptable carrier and additionally 1 to 80% by weight of one or more additives selected from a solubilizing aid, a softening agent, a surfactant, a thickening agent and a pH controller. The preparation is applied to the peripheral surface of the penis and the clitoris in a single dose of about 0.1 to 2g.

Abstract translation: 目的：用于透皮给药的组合物，其包含L-精氨酸，其具有优异的治疗效果，并且即使以过量作为主要药物也不会产生不良反应。 该组合物是克服常规注射或口服治疗剂的缺陷并有效治疗勃起功能障碍和寒冷的外部应用。 构成：用于透皮给药的制剂含有1至20重量％的L-精氨酸，1至30重量％的皮肤渗透促进剂，药学上可接受的载体，另外1至80重量％的一种或多种添加剂选自 增溶助剂，软化剂，​​表面活性剂，增稠剂和pH控制剂。 该制剂以约0.1至2g的单次剂量施用于阴茎和阴蒂的外周表面。