公开(公告)号：KR1020090012439A

公开(公告)日：2009-02-04

申请号：KR1020070076258

申请日：2007-07-30

Applicant: (주)차바이오텍 ,  가톨릭대학교 산학협력단

Inventor： 조광용 ,  김진훈 ,  한규범 ,  전신수 ,  전진애 ,  박상인

IPC: A61K31/728 ,  A61P17/02

CPC classification number: A61K31/738 ,  A61K9/06 ,  A61K9/7007 ,  A61K2121/00

Abstract: A hyaluronic acid and a carboxy methyl cellulose composite derivative film is provided to have trachea reducing adhesion property, excellent biodegradation property and property absorbed by being completely disassembled after preventing adhesion phenomenon. An N-acylation urea pendant form and an auto-cross-linking form are mixed in hyaluronic acid and carboxy methyl cellulose composite derivative film. The N-acylation urea pendant form and an auto-cross-linking form are made by reacting crosslink activity agent and cross linkage activity supplement at hyaluronic acid and carboxy methyl cellulose complex film surface. The derivative film with the N-acylation urea pendant form is formed by using the crosslink activity agent 0.01 ~ 500 parts by weight and the cross linkage activity supplement 0.01 ~ 200 parts by weight based on compound of the carboxy methyl cellulose and hyaluronic acid 100 parts by weight. The derivative film with the auto-cross-linking form is formed by using the crosslink activity agent 0.01 ~ 500 parts by weight and the cross linkage activity supplement 40 ~ 1000 parts by weight.

Abstract translation: 提供透明质酸和羧甲基纤维素复合衍生物膜，以具有气管降低粘附性，优异的生物降解性能和性能在防止粘附现象后被完全分解吸收。 透明质酸和羧甲基纤维素复合衍生物膜混合N-酰化脲的侧链形式和自动交联形式。 通过在透明质酸和羧甲基纤维素复合膜表面上交联活性剂和交联活性补充剂反应制备N-酰化脲垂饰形式和自动交联形式。 通过使用0.01〜500重量份的交联活性剂和基于羧甲基纤维素和透明质酸化合物的交联活性补充0.01〜200重量份形成具有N-酰化脲侧链形式的衍生物膜100份 重量。 具有自交联形式的衍生物膜通过使用0.01〜500重量份的交联活性剂形成，交联活性为40〜1000重量份。