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公开(公告)号：KR1020140057824A
公开(公告)日：2014-05-14
申请号：KR1020120124064
申请日：2012-11-05
Applicant: (주)한국비엠아이
IPC: A61K9/08 , A61K38/47 , C07K16/06 , A61K39/395
CPC classification number: A61K47/34 , A61K9/0019 , A61K38/47 , A61K47/10 , A61K47/183 , C12N9/2408 , C12N9/2474 , C12N9/96 , C12Y302/01035
Abstract: The present invention relates to a stable liquid formulation comprising hyaluronidase and a stabilizer of hyaluronidase and, more specifically, to a stable liquid formulation comprising the hyaluronidase stabilizer. According to a high-purification method of highly purified hyaluronidase of the present invention, purity of a conventional commercialized hyaluronidase can be increased.
Abstract translation: 本发明涉及包含透明质酸酶和透明质酸酶稳定剂的稳定液体制剂，更具体地涉及包含透明质酸酶稳定剂的稳定液体制剂。 根据本发明的高纯度透明质酸酶的高纯化方法，可以提高常规的商业化透明质酸酶的纯度。
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公开(公告)号：KR1020130000988A
公开(公告)日：2013-01-03
申请号：KR1020110061827
申请日：2011-06-24
Applicant: (주)한국비엠아이
CPC classification number: C12N9/2474 , B01D15/3804 , C07K1/22 , C12Y302/01035
Abstract: PURPOSE: A method for highly purifying hyaluronidase, and an injection using the same are provided to enhance the purity of existing hyaluronidase, and to ensure safety. CONSTITUTION: A method for highly purifying hyaluronidase comprises: a step of extracting hyaluronidase from ovine testis, and freeze-drying the hyaluronidase; a step of primarily purifying the hyaluronidase by blue sepharose; and a step of secondarily purifying sodium phosphate using the purified hyaluronidase. An injection contains the purified hyaluronidase.
Abstract translation: 目的：提供高纯度透明质酸酶的方法和使用其的注射方法，以提高现有透明质酸酶的纯度，并确保安全性。 构成：高纯度透明质酸酶的方法包括：从绵羊睾丸提取透明质酸酶，冷冻干燥透明质酸酶的步骤; 主要通过蓝色琼脂糖纯化透明质酸酶的步骤; 以及使用纯化的透明质酸酶二次提纯磷酸钠的工序。 注射液含有纯化的透明质酸酶。
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公开(公告)号：KR101454646B1
公开(公告)日：2014-10-27
申请号：KR1020120124064
申请日：2012-11-05
Applicant: (주)한국비엠아이
IPC: A61K9/08 , A61K38/47 , C07K16/06 , A61K39/395
CPC classification number: A61K47/34 , A61K9/0019 , A61K38/47 , A61K47/10 , A61K47/183 , C12N9/2408 , C12N9/2474 , C12N9/96 , C12Y302/01035
Abstract: 본 발명은 히알루로니다아제를 포함하는 안정한 액상제제 및 히알루로니다아제의 안정화제에 관한 것으로서, 더욱 구체적으로는 상기 히알루로니다아제에 안정화제를 첨가하여 안정한 액상제제에 관한 것이다.
Abstract translation: 本发明涉及包含透明质酸酶和透明质酸酶稳定剂的稳定液体制剂，更具体地说，涉及通过向透明质酸酶加入稳定剂而得到稳定的液体制剂。
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公开(公告)号：KR1020140058721A
公开(公告)日：2014-05-15
申请号：KR1020120124065
申请日：2012-11-05
Applicant: (주)한국비엠아이
Abstract: The present invention relates to a high-purity hyaluronidase purification method for obtaining high-purity hyaluronidase, and more specifically, to a purification method for obtaining high-purity hyaluronidase which can stably maintain enzyme activity in a liquid phase for a long time. According to the present invention, a purification method for obtaining high-purity hyaluronidase having more than 95% purity and more than 70,000IU/mg inactivity is provided.
Abstract translation: 本发明涉及一种获得高纯度透明质酸酶的高纯度透明质酸酶纯化方法，更具体地说，涉及一种能够长时间稳定地维持液相酶活性的高纯度透明质酸酶的纯化方法。 根据本发明，提供了用于获得纯度高于95％，超过70,000IU / mg不活动的高纯度透明质酸酶的纯化方法。
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