公开(公告)号：KR1020110014820A

公开(公告)日：2011-02-14

申请号：KR1020090072366

申请日：2009-08-06

Applicant: 가톨릭대학교 산학협력단

Inventor： 박용일 ,  나예슬 ,  김우중

IPC: A61K31/715 ,  A61K36/05 ,  A61P7/02 ,  A61P29/00

CPC classification number: A61K31/737 ,  A61K36/05 ,  A61K2236/53 ,  Y10S514/822 ,  Y10S514/886

Abstract: PURPOSE: A polysaccharide extracted from Capsosiphon fulvescens with anti-thrombotic effect and immunity is provided to produce a large amount of polysaccharide without side effects. CONSTITUTION: A polysaccharide having anti-thrombotic effect and immunity is isolated from Capsosiphon fulvescens. The polysaccharide is a soluble polysaccharide containing sulfate residue. The polysaccharide contains mannose and galactose as a main ingredient. A composition contains the polysaccharide as an active ingredient. A method for preparing the polysaccharide comprises: a step of neutralizing hydrolyzed extract of Capsosiphon fulvescens; a step of precipitating with alcohol of 1-4 carbon atoms, ethyl acetate, hexane, dichloromethane, or mixture solvent thereof and centrifuging to obtain a first precipitate; a step of treating the first precipitate with calcium chloride(CaCl_2) and centrifuging to obtain a supernatant; a step of treating the supernatant with alcohol of 1-4 carbon atoms, ethyl acetate, hexane, dichloromethane, or mixture solvent thereof to obtain a second precipitate; and a step of dialyzing the second precipitate and drying.

Abstract translation: 目的：提供具有抗血栓形成作用和免疫力的辣椒素提取的多糖，以产生大量的多糖，无副作用。 构成：从Capsosiphon fulvescens中分离出具有抗血栓形成作用和免疫力的多糖。 多糖是含有硫酸盐残基的可溶性多糖。 多糖含有甘露糖和半乳糖作为主要成分。 组合物含有多糖作为活性成分。 制备多糖的方法包括：中和辣椒皂苷的水解提取物的步骤; 用1-4个碳原子的醇沉淀的步骤，乙酸乙酯，己烷，二氯甲烷或其混合溶剂，并离心得到第一沉淀物; 用氯化钙（CaCl 2）处理第一沉淀物并离心以获得上清液的步骤; 用1-4个醇的醇处理上清液的步骤，乙酸乙酯，己烷，二氯甲烷或其混合溶剂，得到第二沉淀物; 和透析第二沉淀物并干燥的步骤。