公开(公告)号：KR1020120004075A

公开(公告)日：2012-01-12

申请号：KR1020100064736

申请日：2010-07-06

Applicant: 가톨릭대학교 산학협력단

Inventor： 이문용 ,  문영화 ,  신유진

IPC: C12Q1/68 ,  C12N15/12 ,  G01N33/53 ,  G01N33/15

CPC classification number: C12Q1/6883 ,  C12Q2600/158 ,  G01N33/15 ,  G01N33/5302 ,  G01N33/5308

Abstract: PURPOSE: A composition containing T1R2, T1R3 or alpha-gustducin gene is provided to ensure diagnosis accuracy and to early treat ischemia. CONSTITUTION: A composition for diagnosing ischemic diseases contains an agent for measuring mRNA or protein level of T1R2, T1R3, or alpha-gustducin gene. T1R2 and T1R3 has a base sequence of sequence number 1 and 2, respectively. A method or providing information for diagnosing ischemic diseases comprises: a step of measuring T1R2, T1R3, or alpha-gustducin gene and protein expression level from a biological sample of a patient; and a step of comparing expression and protein level with a control group.

Abstract translation: 目的：提供含有T1R2，T1R3或α-内脏蛋白基因的组合物，以确保诊断准确性和早期治疗缺血。 构成：用于诊断缺血性疾病的组合物含有用于测量T1R2，T1R3或α-内脏素基因的mRNA或蛋白质水平的试剂。 T1R2和T1R3分别具有序列号1和2的碱基序列。 用于诊断缺血性疾病的方法或提供信息包括：从患者的生物样品测量T1R2，T1R3或α-内脏素基因和蛋白质表达水平的步骤; 以及将表达和蛋白质水平与对照组进行比较的步骤。

公开(公告)号：KR101727750B1

公开(公告)日：2017-04-19

申请号：KR1020100064736

申请日：2010-07-06

Applicant: 가톨릭대학교 산학협력단

Inventor： 이문용 ,  문영화 ,  신유진

IPC: C12Q1/68 ,  C12N15/12 ,  G01N33/53 ,  G01N33/15

Abstract: 본발명은 T1R2, T1R3 및α-거스트듀신중 선택되는 1종이상의유전자의허혈질환진단마커로서의용도에관한것으로, 보다구체적으로본 발명은상기유전자를함유하는허혈질환진단용조성물, 허혈질환진단방법및 성상세포의 T1R2, T1R3 및α-거스트듀신유전자의상향조절된발현을억제하는물질을스크리닝하여허혈질환의치료제를스크리닝하는방법에관한것이다. 본발명에따른허혈질환과관련된신규한 T1R2, T1R3 및α-거스트듀신유전자마커는질병을진단하는정확도가우수하여조기에허혈질환을진단하고치료하는용도로유용하게활용할수 있다.