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Patent Agency Ranking
公开(公告)号：KR100570810B1
公开(公告)日：2006-04-28
申请号：KR1020030065991
申请日：2003-09-23
Applicant: 주식회사 바이오씨에스 , 노정래 , 신종헌 , 가톨릭대학교 산학협력단
IPC: C07C235/28
Abstract: 본 발명은 신규 세라마이드 유도체, 이의 제조방법 및 이의 용도에 관한 것으로서, 보다 상세하게는 하기 화학식 2로 표시되는 세라마이드 유도체, 이의 제조방법, 이를 포함하는 화장료 조성물 및 약학적 조성물에 관한 것이다.
상기 식에서,
R
1 은 수소 또는 C1-C14의 알킬기이고;
R
2 는 수소, 하이드록시기 또는 C1-C11의 알킬기이고;
R
3 는 6-메틸 펜타데카-1,5,7-트리엔, 1-하이드록시-노나데카-11-엔 및 노나데카-1,10-다이엔으로 이루어진 군에서 선택되는 어느 하나이고; 및
R
4 는 수소 또는 C1-C6의 알콕시기이다.
세라마이드 유도체, 피부보호, 아폽토시스-
公开(公告)号：KR100839225B1
公开(公告)日：2008-06-17
申请号：KR1020070061850
申请日：2007-06-22
Applicant: 가톨릭대학교 산학협력단
CPC classification number: A61Q19/08 , A61K8/498 , A61K2800/28 , A61Q19/02
Abstract: A cosmetic composition comprising sargachromenol is provided to induce apoptosis on human keratinocyte significantly, thereby being usefully used in order to prevent and improving skin diseases caused by skin aging, photo-aging and pigmentation. A cosmetic composition for preventing and improving skin diseases comprises sargachromenol represented by a formula(1) and isolated from Sargassum sagamianum as an effective ingredient, wherein the skin disease is a skin disease caused by proliferation of keratinocyte such as skin aging, photo-aging, and a pigmentation disease.
Abstract translation: 提供了包含萨格罗莫酚的化妆品组合物，以显着地诱导人角质形成细胞凋亡，从而有用地用于预防和改善由皮肤老化，光老化和色素沉着引起的皮肤疾病。 用于预防和改善皮肤疾病的化妆品组合物包括由式（1）表示的并且从马齿苋（Sargassum sagamamum）分离出的作为有效成分的草甘膦醇，其中皮肤病是皮肤老化，光老化等角化细胞增生引起的皮肤病， 和色素沉着病。
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公开(公告)号：KR1020050029785A
公开(公告)日：2005-03-29
申请号：KR1020030065991
申请日：2003-09-23
Applicant: 주식회사 바이오씨에스 , 노정래 , 신종헌 , 가톨릭대학교 산학협력단
IPC: C07C235/28
Abstract: Provided are a ceramide derivative which promotes apoptosis, its preparation method, and a cosmetic composition and a pharmaceutical composition for the treatment of skin disease or cancer containing the derivative or its salt. The ceramide derivative is represented by the formula 2, wherein R1 is H or a C1-C14 alkyl group; R2 is H, a hydroxyl group or a C1-C11 alkyl group; R3 is a 6-methyl-pentadeca-1,5,7-triene group, a 1-hydroxy-nonadeca-11-ene group or a nonadeca-1,11-diene group; and R4 is H or a C1-C6 alkoxy group. The method comprises the steps of extracting a starfish with an organic solvent; concentrating the extract under reduced pressure and fractionating the concentrated one with a solvent mixture of methanol and hexane according to polarity to obtain an active fraction; and separating and purifying the active fraction by chromatography. Preferably the starfish is Distolasterias nipon.
Abstract translation: 提供促进细胞凋亡的神经酰胺衍生物，其制备方法和化妆品组合物和用于治疗皮肤病或含有衍生物或其盐的癌症的药物组合物。 神经酰胺衍生物由式2表示，其中R 1是H或C 1 -C 14烷基; R2是H，羟基或C1-C11烷基; R3是6-甲基 - 十五碳-5,7-三烯基，1-羟基 - 十九碳十一烯-11-烯基或十五碳-1,11-二烯基; R4为H或C1-C6烷氧基。 该方法包括用有机溶剂萃取海星的步骤; 在减压下浓缩提取物，并用甲醇和己烷的溶剂混合物根据极性对浓缩物进行分级，得到活性级分; 并通过色谱法分离和纯化活性级分。 海星最好是杜鹃花。
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公开(公告)号：KR100889806B1
公开(公告)日：2009-03-20
申请号：KR1020060039496
申请日：2006-05-02
Applicant: 가톨릭대학교 산학협력단
IPC: A61K31/192 , A61P17/00
Abstract: 본 발명은 피부질환 및 피부암의 예방 또는 치료용 약학적 조성물에 관한 것이다. 보다 구체적으로, 본 발명은 하기 화학식 I로 표시되는 사가퀴노익산(Sargaquinoic acid)을 유효성분으로 함유하는 피부질환 및 피부암의 예방 또는 치료용 약학적 조성물에 관한 것이다.
사가퀴노익산, 피부질환, 피부암-
公开(公告)号：KR1020070107252A
公开(公告)日：2007-11-07
申请号：KR1020060039496
申请日：2006-05-02
Applicant: 가톨릭대학교 산학협력단
IPC: A61K31/192 , A61P17/00
Abstract: A pharmaceutical composition containing Sargaquinoic acid for preventing or treating skin disease and skin cancer is provided to prevent and treat diseases associated with hyperplastic skin cells by inducing cytotoxicity and apoptosis of skin cells, and promotes apoptosis by irradiating ultraviolet rays. A pharmaceutical composition for preventing or treating skin disease and skin cancer contains Sargaquinoic acid represented by the formula(I) or its pharmaceutically acceptable salt as an effective ingredient, wherein the medicinal effects of the pharmaceutical composition are increased by irradiating ultraviolet rays and the skin disease is hyperplastic skin disease including psoriasis, fishskin disease, Bowen's disease, papilloma, eczema, eczema, atopic dermatitis, acne vulgaris, dermatitis, lichen planus, striatus, foot hyperkeratosis, dark spots, actinic keratosis, skin aging and photoaging.
Abstract translation: 提供含有用于预防或治疗皮肤病和皮肤癌的夸喹酸的药物组合物，通过诱导皮肤细胞的细胞毒性和凋亡来预防和治疗与增生性皮肤细胞相关的疾病，并通过照射紫外线来促进细胞凋亡。 用于预防或治疗皮肤病和皮肤癌的药物组合物含有由式（I）表示的橙胆酸或其药学上可接受的盐作为有效成分，其中药物组合物的药物作用通过照射紫外线和皮肤病增加 是增生性皮肤病，包括牛皮癣，鱼皮病，鲍文氏病，乳头状瘤，湿疹，湿疹，特应性皮炎，寻常痤疮，皮炎，扁平苔藓，条纹，足角化病，黑斑，光化性角化病，皮肤老化和光老化。
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