公开(公告)号：KR1020100043814A

公开(公告)日：2010-04-29

申请号：KR1020080103018

申请日：2008-10-21

Applicant: 가톨릭대학교 산학협력단

Inventor： 주대명 ,  최진 ,  김호연

IPC: A61K31/12 ,  A61P19/02

Abstract: PURPOSE: A pharmaceutical composition containing N-tosyl-L-phenylalanine chloromethyl ketone(TPCK) is provided to suppress NF-kappa(nuclear factor-kappa B) and expression of osteoclastogenic gene and to treat erosion of bone and cartilage. CONSTITUTION: A pharmaceutical composition for treating arthritis contains N-tosyl-L-phenylalanine chloromethyl ketone](TPCK). Arthritis is rheumatoid arthritis. The composition is formulated in the form of intraperitoneal administration. The composition suppresses erosion of bone and cartilage. The composition is used in the form of powder, granule, tablet, capsule, suspension liquid, emulsion, syrup, aerosol oral formulation, and sterilization injection solution.

Abstract translation: 目的：提供含有N-甲苯磺酰基-L-苯丙氨酸氯甲基酮（TPCK）的药物组合物，以抑制NF-κB（核因子κB）和破骨细胞发生基因的表达，并治疗骨和软骨的侵蚀。 构成：用于治疗关节炎的药物组合物含有N-甲苯磺酰基-L-苯丙氨酸氯甲基酮〕（TPCK）。 关节炎是类风湿关节炎。 组合物以腹膜内给药的形式配制。 该组合物抑制骨和软骨的侵蚀。 该组合物以粉末，颗粒，片剂，胶囊，悬浮液，乳剂，糖浆，气溶胶口服制剂和灭菌注射溶液的形式使用。