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公开(公告)号：KR101318031B1
公开(公告)日：2013-10-14
申请号：KR1020110081434
申请日：2011-08-17
Applicant: 강원대학교산학협력단
Abstract: 본 발명은 프로스타글란딘(PGE
2 ), AP-1 및 TNF-α의 발현 및 생성을 억제하도록 하여 항염증 및 면역조절 활성에 효과가 있고, 염증성 및 자가면역성 질환의 예방 및 개선에 효과가 있다. 이를 위해 특히, 수식화된 나노섬유를 이용하는 펩타이드를 포함하는 것을 특징으로 하는 염증성 및 자가면역성 질환의 예방 및 개선용 약학조성물이 개시된다.-
公开(公告)号：KR1020130019472A
公开(公告)日：2013-02-27
申请号：KR1020110081434
申请日：2011-08-17
Applicant: 강원대학교산학협력단
CPC classification number: A61K38/16 , A61K9/06 , A61K38/38 , Y10S514/885 , Y10S514/886
Abstract: PURPOSE: A peptide nanofiber for preventing and treating inflammatory and autoimmune diseases is provided to suppress expression and generation of PGE2(prostaglandin), AP-1, and TNF-alpha and to prevent and treat the diseases. CONSTITUTION: A peptide nanofiber for preventing and treating inflammatory and autoimmune diseases is a self-assembly type. The peptide nanofiber includes lysozyme, a trypsin inhibitor, BSA(bovine serum albumin), and IgG protein. The peptide nanofiber contains Acetyl-(Arg-Ala-Asp-Ala)4-CONH2[Ac-(RADA)4-CONH2] peptide hydrogel. The peptide nanofiber suppresses PGE2, AP-1, and TNF-alpha activation.
Abstract translation: 目的：提供用于预防和治疗炎症和自身免疫疾病的肽纳米纤维，以抑制PGE2（前列腺素），AP-1和TNF-α的表达和产生并预防和治疗疾病。 构成：用于预防和治疗炎性和自身免疫性疾病的肽纳米纤维是一种自组装型。 肽纳米纤维包括溶菌酶，胰蛋白酶抑制剂，BSA（牛血清白蛋白）和IgG蛋白。 肽纳米纤维含有乙酰基 - （Arg-Ala-Asp-Ala）4-CONH 2 [Ac-（RADA）4-CONH 2]肽水凝胶。 肽纳米纤维抑制PGE2，AP-1和TNF-α激活。
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公开(公告)号：KR1020140087724A
公开(公告)日：2014-07-09
申请号：KR1020120158317
申请日：2012-12-31
Applicant: 강원대학교산학협력단
CPC classification number: A61K38/08 , C07K7/06 , Y10S514/886
Abstract: The present invention relates to a peptide composition having an anti-inflammatory effect, wherein the peptide composition is represented by chemical formula 1. In the chemical formula 1, R1, R4, and R5 are hydrogen; R2 and R3 are hydroxyl; K is Lys; G is Gly; T is Thr; E is Glu; and C is Cys. Accordingly, the peptide composition has high in vivo transferring efficiency, does not inhibit immune macrophages, and has an anti-inflammatory effect for inhibiting the activities of PGE2 and AP-1.
Abstract translation: 本发明涉及具有抗炎作用的肽组合物，其中肽组合物由化学式1表示。在化学式1中，R 1，R 4和R 5是氢; R2和R3是羟基; K为Lys; G是Gly; T是Thr; E是Glu; C是Cys。 因此，肽组合物具有高的体内转移效率，不抑制免疫巨噬细胞，并且具有抑制PGE2和AP-1的活性的抗炎作用。
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公开(公告)号：KR1020140087723A
公开(公告)日：2014-07-09
申请号：KR1020120158315
申请日：2012-12-31
Applicant: 강원대학교산학협력단
CPC classification number: A61K38/177 , A61K9/06 , C07K14/4713 , Y10S424/81 , Y10S514/886
Abstract: The present invention relates to a pharmaceutical composition for preventing and treating inflammatory and autoimmune diseases, wherein the pharmaceutical composition includes peptide represented by SEQ ID NO: 1 as an active ingredient. Accordingly, the pharmaceutical composition has high in vivo transferring efficiency, does not inhibit immune macrophages, and inhibits the activities of PGE2, AP-1, and TNF-α.
Abstract translation: 本发明涉及用于预防和治疗炎性和自身免疫性疾病的药物组合物，其中该药物组合物包含SEQ ID NO：1所示的肽作为活性成分。 因此，药物组合物具有高的体内转移效率，不抑制免疫巨噬细胞，并且抑制PGE2，AP-1和TNF-α的活性。
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