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Patent Agency Ranking
公开(公告)号：KR1020140026777A
公开(公告)日：2014-03-06
申请号：KR1020120092373
申请日：2012-08-23
Applicant: 강원대학교산학협력단
Abstract: The present invention relates to monoolein cubic phase nanoparticles surface-modified with hydrophobized cationic polymers and a manufacturing method thereof. A manufacturing method for the monoolein cubic phase nanoparticles surface-modified with hydrophobized cationic polymers comprises: a step of manufacturing monoolein cubic phases capturing target materials in a water channel by adding an aqueous solution including the target materials in a monoolein melt solution and hydrating the ingredients; and a step of manufacturing monoolein cubic phase nanoparticles coated with hydrophobized cationic polymers on the surfaces by adding water phases in which the hydrophobized cationic polymers and dispersing agents are dissolved on monoolein cubic phases capturing the target materials and homogenizing ingredients. The monoolein cubic phase nanoparticles surface-modified with hydrophobized cationic polymers according to the present invention increase skin persistence by electrostatic interaction with the surface of skin by modifying the surfaces of monoolein cubic phase nanoparticles with hydrophobized cationic polymers and is able to improve the penetrability of target materials.
Abstract translation: 本发明涉及用疏水化阳离子聚合物表面改性的单油酸酯立方相纳米粒子及其制造方法。 用疏水化阳离子聚合物表面改性的单油酸酯立方相纳米颗粒的制造方法包括：通过在单油溶液熔融溶液中加入包含目标物质的水溶液并使成分水合而制备单油酸酯立方相在水通道中捕获目标物质的步骤 ; 并且通过加入其中将疏水化阳离子聚合物和分散剂溶解在捕获靶材料和匀浆成分的单油酸酯立方相上的水相，制备在表面上涂覆有疏水化阳离子聚合物的单油酸酯立方相纳米颗粒的步骤。 用根据本发明的疏水化阳离子聚合物表面改性的单油酸酯立方相纳米颗粒通过用疏水化阳离子聚合物改性单油酸酯立方相纳米颗粒的表面而通过与皮肤表面的静电相互作用增加皮肤持久性，并且能够提高靶的渗透性 材料。
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公开(公告)号：KR1020130122309A
公开(公告)日：2013-11-07
申请号：KR1020120045541
申请日：2012-04-30
Applicant: 강원대학교산학협력단
IPC: A61K9/06 , A61K31/336 , A61P17/00
CPC classification number: A61K9/1075 , A61K9/113 , A61K31/336 , A61K47/44
Abstract: The present invention relates to a microemulsion which is manufactured to enhance chemical stability of fucoxanthine and to improve skin penetration. The present invention provides a microemulsion which is characterized by containing an oil phase containing fucoxanthine loaded in oil droplets, a surfactant/cosurfactant mixture added to the oil phase, and an aqueous phase with enhanced stability of fucoxanthine and skin penetration.
Abstract translation: 本发明涉及一种微乳液，其被制造以提高岩藻黄素的化学稳定性并改善皮肤渗透性。 本发明提供了一种微乳液，其特征在于含有装载在油滴中的富柔比黄油的油相，添加到油相中的表面活性剂/辅助表面活性剂混合物和具有增强的岩藻黄素稳定性和皮肤渗透性的水相。
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公开(公告)号：KR101400962B1
公开(公告)日：2014-05-28
申请号：KR1020120045541
申请日：2012-04-30
Applicant: 강원대학교산학협력단
IPC: A61K9/06 , A61K31/336 , A61P17/00
Abstract: 본 발명은 마이크로에멀젼에 관한 것으로, 푸코잔틴(fucoxanthine)의 화학적 안정성을 증가시키고 피부 침투성을 향상시키기 위하여 제조된 마이크로에멀젼(microemulsion)에 관한 것이다.
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公开(公告)号：KR101387059B1
公开(公告)日：2014-04-21
申请号：KR1020120092373
申请日：2012-08-23
Applicant: 강원대학교산학협력단
Abstract: 본 발명은 소수화된 양이온성 고분자로 표면 개질된 모노올레인 큐빅상 나노입자 및 그 제조방법에 관한 것으로서, 본 발명에 따른 소수화된 양이온성 고분자로 표면 개질된 모노올레인 큐빅상 나노입자는 목적물질을 포함하는 수용액을 모노올레인(monoolein) 용융액에 첨가한 후 수화시켜 수상채널에 목적물질이 포집된 모노올레인 큐빅상(monoolein cubic phase)을 제조하는 단계; 상기 목적물질이 포집된 모노올레인 큐빅상에 소수화된 양이온성 고분자와 분산제가 용해된 수상을 첨가한 다음 균질화시켜 외측 표면이 소수화된 양이온성 고분자로 코팅된 모노올레인 큐빅상 나노입자를 제조하는 단계;를 포함하는 것을 특징으로 하는 제조방법에 의해 제조될 수 있다. 상기한 본 발명에 따라 제조되는 소수화된 양이온성 고분자로 표면 개질된 모노올레인 큐빅상 나노입자는 모노올레인 큐빅상 나노입자의 외측 표면을 소수화된 양이온성 고분자로 개질시켜 피부표면과의 정전기적 상호작용에 의하여 피부 잔류성을 증가시키면서 목적물질의 침투성을 향상시킬 수 있는 유용한 효과가 있다.
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公开(公告)号：KR101378934B1
公开(公告)日：2014-03-27
申请号：KR1020130021060
申请日：2013-02-27
Applicant: 강원대학교산학협력단
CPC classification number: A61K9/1271 , A61K9/1277 , A61K47/32
Abstract: The present invention relates to a photo- and temperature-responsive liposome produced by immobilizing a polymer having photo-responsiveness and temperature-responsiveness on a liposome surface, which releases contents in response to photo-irradiation and a temperature change.
Abstract translation: 本发明涉及通过将具有光响应性和温度反应性的聚合物固定在脂质体表面上产生的光和温度响应型脂质体，其能够响应于光照射和温度变化而释放内容物。
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