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公开(公告)号：KR1020130022225A
公开(公告)日：2013-03-06
申请号：KR1020110085081
申请日：2011-08-25
Applicant: 강원대학교산학협력단
IPC: A61K9/16 , A61K31/37 , A61K31/734 , A61K47/06
CPC classification number: A61K9/1658 , A61K9/1617 , A61K9/1652 , A61K41/0042 , A61K47/22
Abstract: PURPOSE: A photoresponsive alginate particle and a method for preparing the same are provided to obtain a photoresponsive bead which is able to control release of a target material by photo-irradiation. CONSTITUTION: A photoresponsive alginate particle is formed by coating an alginate bead with basic proteinoid coumarin conjugate. The basic proteinoid coumarin conjugate is coated on the alginate bead and irradiated with light in wavelength of 310 nm or more. A method for preparing the photoresponsive alginate particle comprises: a step of chemically binding a coumarin derivative with basic proteinoid, and preparing the basic proteinoid coumarin conjugate; a step of dropping an alginate solution to a polyvalent ion solution, and preparing the alginate bead; a step of coating the surface of the alginate bead with the basic proteinoid coumarin conjugate; and a step of irradiating the alginate bead with a UV ray.
Abstract translation: 目的：提供光响应性藻酸盐颗粒及其制备方法以获得能够通过光照照射来控制靶材料释放的光响应珠。 构成：通过用碱性蛋白质香豆素缀合物包被藻酸盐珠粒形成光响应性海藻酸盐颗粒。 将基本的蛋白质香豆素缀合物涂覆在藻酸盐珠上，并用波长为310nm或更大的光照射。 制备光响应性藻酸盐颗粒的方法包括：将香豆素衍生物与碱性类维生素化学结合的步骤，以及制备碱性类维生素香豆素缀合物; 将藻酸盐溶液滴加到多价离子溶液中并制备藻酸盐珠粒的步骤; 用碱性蛋白质香豆素缀合物涂覆藻酸盐珠粒表面的步骤; 以及用紫外线照射藻酸盐珠粒的步骤。
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公开(公告)号：KR1020130122309A
公开(公告)日：2013-11-07
申请号：KR1020120045541
申请日：2012-04-30
Applicant: 강원대학교산학협력단
IPC: A61K9/06 , A61K31/336 , A61P17/00
CPC classification number: A61K9/1075 , A61K9/113 , A61K31/336 , A61K47/44
Abstract: The present invention relates to a microemulsion which is manufactured to enhance chemical stability of fucoxanthine and to improve skin penetration. The present invention provides a microemulsion which is characterized by containing an oil phase containing fucoxanthine loaded in oil droplets, a surfactant/cosurfactant mixture added to the oil phase, and an aqueous phase with enhanced stability of fucoxanthine and skin penetration.
Abstract translation: 本发明涉及一种微乳液，其被制造以提高岩藻黄素的化学稳定性并改善皮肤渗透性。 本发明提供了一种微乳液，其特征在于含有装载在油滴中的富柔比黄油的油相，添加到油相中的表面活性剂/辅助表面活性剂混合物和具有增强的岩藻黄素稳定性和皮肤渗透性的水相。
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公开(公告)号：KR101388646B1
公开(公告)日：2014-04-25
申请号：KR1020120049036
申请日：2012-05-09
Applicant: 강원대학교산학협력단
Abstract: 본 발명은 광 반응성 마이크로겔에 관한 것으로, 구체적으로는 광 반응성 계면활성제와 사이클로 덱스트린 고분자와의 소수성 상호 작용으로 형성된 마이크로겔로써 광조사를 하면 마이크로겔을 구성하는 광 반응성 계면활성제가 이량화(dimerization) 또는 탈이량화(de-dimerization)하여 마이크로겔의 크기, 가교도 등이 급격하게 변하는 광 반응성 마이크로겔에 관한 것이다.
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公开(公告)号：KR101323707B1
公开(公告)日：2013-10-31
申请号：KR1020110083645
申请日：2011-08-22
Applicant: 강원대학교산학협력단
Abstract: 본 발명은 사이클로 덱스트린을 중합시켜 형성된 사이클로 덱스트린 고분자, 쿠마린 및 목적물질을 함유하고, 광 조사에 의해 조성물의 점도가 조절되어 상기 목적물질의 방출을 제어할 수 있는 것을 특징으로 하는 광응답성 수상 조성물을 개시한다.
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公开(公告)号：KR101313256B1
公开(公告)日：2013-09-30
申请号：KR1020110085081
申请日：2011-08-25
Applicant: 강원대학교산학협력단
IPC: A61K9/16 , A61K31/37 , A61K31/734 , A61K47/06
Abstract: 본 발명은 염기성 프로테노이드-쿠마린 결합체(basic proteinoid coumarin conjugate)가 알지네이트 비드(alginate beads)에 코팅되어 있고, 상기 염기성 프로테노이드-쿠마린 결합체는 상기 알지네이트 비드에 코팅된 후 310 nm이상의 파장의 빛이 조사되어 광가교(photo-cross linking)되어 있는 것을 특징으로 하는 광 반응성 비드 (photo-responsive bead)를 개시한다.
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Patent Agency Ranking
公开(公告)号：KR1020130021245A
公开(公告)日：2013-03-05
申请号：KR1020110083645
申请日：2011-08-22
Applicant: 강원대학교산학협력단
CPC classification number: A61K47/40 , A61K9/08 , A61K31/37 , A61K41/0004 , A61K2121/00
Abstract: PURPOSE: A composition with photo-responsive viscosity change, and a method for manufacturing the same are provided to enable the light control of release of a target material. CONSTITUTION: A composition with photo-responsive viscosity change contains coumarin, a target material, and a cyclodextrin polymer which is formed by polymerizing cyclodextrin. A method for manufacturing the composition comprises: a step of crosslinking cyclodextrin, and preparing the cyclodetrin polymer; and a step of dissolving the cyclodextrin polymer, courmarin, and the target material in the water, and preparing an aqueous composition.
Abstract translation: 目的：提供具有光响应粘度变化的组合物及其制造方法，以能够对目标材料的释放进行光线控制。 构成：具有光响应性粘度变化的组合物含有香豆素，靶物质和通过聚合环糊精形成的环糊精聚合物。 制备组合物的方法包括：交联环糊精和制备环糊精聚合物的步骤; 以及将环糊精聚合物，高分子和目标物质溶解在水中的步骤，并制备含水组合物。
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公开(公告)号：KR101400962B1
公开(公告)日：2014-05-28
申请号：KR1020120045541
申请日：2012-04-30
Applicant: 강원대학교산학협력단
IPC: A61K9/06 , A61K31/336 , A61P17/00
Abstract: 본 발명은 마이크로에멀젼에 관한 것으로, 푸코잔틴(fucoxanthine)의 화학적 안정성을 증가시키고 피부 침투성을 향상시키기 위하여 제조된 마이크로에멀젼(microemulsion)에 관한 것이다.
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公开(公告)号：KR101361847B1
公开(公告)日：2014-02-14
申请号：KR1020120020289
申请日：2012-02-28
Applicant: 강원대학교산학협력단
IPC: C07D311/06 , C07C15/28 , G03F7/004 , C09K3/00
Abstract: 본 발명은 광 중합 특성을 갖는 광 반응성 물질(photo-reactive material)이 계면활성제에 결합되어 있는 것을 특징으로 하는 광 감응성 계면활성제(photo-responsive surfactant) 및 그 제조방법을 개시한다.
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公开(公告)号：KR1020130125488A
公开(公告)日：2013-11-19
申请号：KR1020120049036
申请日：2012-05-09
Applicant: 강원대학교산학협력단
CPC classification number: A61K47/40 , A61K9/06 , A61K31/765 , A61K41/00 , A61K2121/00
Abstract: The present invention relates to photoresponsive microgel. Particularly, the present invention relates to photoresponsive microgel which is a microgel formed by hydrophobic interaction between a photoresponsive surfactant and cyclodextrin polymers. When the microgel is irradiated by light, the size and the crosslinking degree of the microgel are sharply changed by dimerization or de-dimerization of the photoresponsive surfactant.
Abstract translation: 本发明涉及光响应微凝胶。 特别地，本发明涉及光响应性微凝胶，其是通过光响应性表面活性剂与环糊精聚合物之间的疏水相互作用形成的微凝胶。 当光照射微凝胶时，微粒凝胶的尺寸和交联度通过光响应性表面活性剂的二聚化或去二聚作用而急剧变化。
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公开(公告)号：KR1020130098628A
公开(公告)日：2013-09-05
申请号：KR1020120020289
申请日：2012-02-28
Applicant: 강원대학교산학협력단
IPC: C07D311/06 , C07C15/28 , G03F7/004 , C09K3/00
CPC classification number: C07D311/06 , C07C15/28 , C09K3/00 , G03F7/004 , G03F7/0045
Abstract: PURPOSE: A photo-sensitive surfactant is provided to enhance interfacial activity by forming a dimer surfactant such as gemini surfactant through photo-irradiation. CONSTITUTION: A photo-sensitive surfactant contains a photo-reactive material with photopolymerization property, which is conjugated with a surfactant. A method for manufacturing the photo-sensitive surfactant comprises the steps of: dissolving the photo-reactive material with the surfactant in an organic solvent to prepare a mixture solution; and stirring the mixture solution at 50-70°C for 45-50 hours.
Abstract translation: 目的：提供光敏表面活性剂以通过光照射形成二聚体表面活性剂如双子表面活性剂来增强界面活性。 构成：光敏表面活性剂含有具有光聚合性质的光反应性材料，其与表面活性剂结合。 制造感光性表面活性剂的方法包括以下步骤：将光反应性物质与表面活性剂溶解在有机溶剂中以制备混合溶液; 并将混合溶液在50-70℃下搅拌45-50小时。
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