公开(公告)号：KR101452337B1

公开(公告)日：2014-10-22

申请号：KR1020140065859

申请日：2014-05-30

Applicant: 강원대학교산학협력단

Inventor： 이필호 ,  박영철 ,  전인철 ,  서정민 ,  서보람

IPC: C07F9/6574 ,  C07F9/6581

CPC classification number: C07F9/65846 ,  C07F9/657163 ,  C07F9/657172 ,  C07F9/657181

Abstract: The present invention relates to a novel phosphinine oxide derivative and a preparing method thereof. More specifically, the phosphinine oxide derivative of the present invention comprises oxaphosphinine oxide and azaphosphinine oxide derivatives. The phosphinine oxide derivative according to the present invention has pharmacological activity and bioactivity, and can be used in novel drug development and synthesis of various pharmaceuticals as well as used as a basic structure of natural materials. In addition, the method for preparing the phosphinine oxide derivative according to the present invention has strong points of preparing various phosphinine oxide derivatives having high yield through a simple synthesizing process by conducting intermolecular cyclicizing reaction of a phosphinine derivative and an alkyne derivative with a rhodium (Rh) catalyst or a ruthenium (Ru) catalyst and an oxidizing agent.

Abstract translation: 本发明涉及一种新的次膦酰氧化物衍生物及其制备方法。 更具体地，本发明的次膦氧化物衍生物包含氧化磷腈氧化物和氮杂磷酸氧化物衍生物。 本发明的次膦氧化物衍生物具有药理活性和生物活性，可用于各种药物的新药开发和合成，也可用作天然物质的基本结构。 此外，根据本发明的制备氧化膦氧化物衍生物的方法通过简单的合成方法制备具有高产率的各种次膦酸氧化物衍生物的优点是通过将次膦酸衍生物和炔衍生物与铑进行分子间环化反应（ Rh）催化剂或钌（Ru）催化剂和氧化剂。

公开(公告)号：KR101623704B1

公开(公告)日：2016-05-24

申请号：KR1020150026928

申请日：2015-02-26

Applicant: 강원대학교산학협력단

Inventor： 이필호 ,  서보람 ,  전우형

IPC: C07C311/43 ,  C07C13/567 ,  C07C311/37

Abstract: 본발명은신규한하기화학식 1로표시되는플루오렌유도체및 이의제조방법에관한것이다. [화학식 1][상기화학식 1에서,, L, R, R, R, R및 R은발명의상세한설명에정의된바와동일하다.]

Abstract translation: 本发明涉及由化学式1表示的能够用作有机电子材料和生物活性物质的新型有效芴衍生物及其制造方法。 在化学式1中，L，R 1，R 2，R 3，R 6和R 9与本发明的详细描述中定义相同。

公开(公告)号：KR101834224B1

公开(公告)日：2018-03-05

申请号：KR1020160149343

申请日：2016-11-10

Applicant: 강원대학교산학협력단

Inventor： 이필호 ,  서보람 ,  김야곱

IPC: C07D275/02 ,  C07D417/06 ,  C07D513/04

CPC classification number: C07D275/02 ,  C07D417/06 ,  C07D513/04

Abstract: 본발명은이소티아졸유도체의제조방법에관한것으로, 보다상세하게본 발명의이소티아졸유도체의제조방법은클로로(1,5-시클로옥타디엔)로듐(Ⅰ)다이머촉매및 1,1'-비스(디페닐포스피노)페로센존재하에분자간고리화반응으로 3-치환된이소티아졸유도체또는분자내고리화반응으로 3,4-접합된이소티아졸유도체를높은선택성및 수율로얻을수 있는매우효율적인방법이다.