公开(公告)号：KR101452337B1

公开(公告)日：2014-10-22

申请号：KR1020140065859

申请日：2014-05-30

Applicant: 강원대학교산학협력단

Inventor： 이필호 ,  박영철 ,  전인철 ,  서정민 ,  서보람

IPC: C07F9/6574 ,  C07F9/6581

CPC classification number: C07F9/65846 ,  C07F9/657163 ,  C07F9/657172 ,  C07F9/657181

Abstract: The present invention relates to a novel phosphinine oxide derivative and a preparing method thereof. More specifically, the phosphinine oxide derivative of the present invention comprises oxaphosphinine oxide and azaphosphinine oxide derivatives. The phosphinine oxide derivative according to the present invention has pharmacological activity and bioactivity, and can be used in novel drug development and synthesis of various pharmaceuticals as well as used as a basic structure of natural materials. In addition, the method for preparing the phosphinine oxide derivative according to the present invention has strong points of preparing various phosphinine oxide derivatives having high yield through a simple synthesizing process by conducting intermolecular cyclicizing reaction of a phosphinine derivative and an alkyne derivative with a rhodium (Rh) catalyst or a ruthenium (Ru) catalyst and an oxidizing agent.

Abstract translation: 本发明涉及一种新的次膦酰氧化物衍生物及其制备方法。 更具体地，本发明的次膦氧化物衍生物包含氧化磷腈氧化物和氮杂磷酸氧化物衍生物。 本发明的次膦氧化物衍生物具有药理活性和生物活性，可用于各种药物的新药开发和合成，也可用作天然物质的基本结构。 此外，根据本发明的制备氧化膦氧化物衍生物的方法通过简单的合成方法制备具有高产率的各种次膦酸氧化物衍生物的优点是通过将次膦酸衍生物和炔衍生物与铑进行分子间环化反应（ Rh）催化剂或钌（Ru）催化剂和氧化剂。