公开(公告)号：KR1020140000531A

公开(公告)日：2014-01-03

申请号：KR1020120067758

申请日：2012-06-25

Applicant: 강원대학교산학협력단

Inventor： 박해일 ,  양준화

IPC: C07D471/08 ,  C07D403/12 ,  A61K31/439 ,  C07D401/12

CPC classification number: C07D471/08 ,  A61K31/439 ,  C07D401/12 ,  C07D403/12

Abstract: The present invention relates to a novel bicyclic GPRC agonist and, more specifically, a novel bicyclic compound having an effect in promoting GPR119(Glucose-protein coupled receptor 119) activity, a composition containing the compound and a pharmaceutically acceptable salt of the same compound for preventing and treating diseases selected from the group consisting of obesity, diseases associated with obesity, diabetes, diabetic complications, metabolism disorder, and cardiovascular disease.

Abstract translation: 本发明涉及新的双环GPRC激动剂，更具体地说，涉及促进GPR119（葡萄糖 - 蛋白偶联受体119）活性的新型双环化合物，含有该化合物的化合物和药学上可接受的盐的组合物用于 预防和治疗选自肥胖，与肥胖相关的疾病，糖尿病，糖尿病并发症，代谢障碍和心血管疾病的疾病。

公开(公告)号：KR101705390B1

公开(公告)日：2017-02-09

申请号：KR1020120067758

申请日：2012-06-25

Applicant: 강원대학교산학협력단

Inventor： 박해일 ,  양준화

IPC: C07D471/08 ,  C07D403/12 ,  A61K31/439 ,  C07D401/12

Abstract: 본발명은이중환구조를갖는신규한 GPCR 효능제에관한것으로서, 보다자세하게본 발명은이중환구조를갖는 GPR119(Glucose-protein coupled receptor 119)의활성을촉진시키는작용을갖는신규화합물, 이의약학적으로허용가능한염 및상기화합물을유효성분으로포함하는비만, 비만관련질환, 당뇨병, 당뇨합병증, 대사장애및 심혈관질환으로이루어진군 중에서선택되는질환의예방및 치료용조성물에관한것이다.

Abstract translation: 本发明涉及新的双环GPRC激动剂，更具体地说，涉及促进GPR119（葡萄糖 - 蛋白偶联受体119）活性的新型双环化合物，含有该化合物的化合物和药学上可接受的盐的组合物用于 预防和治疗选自肥胖，与肥胖相关的疾病，糖尿病，糖尿病并发症，代谢障碍和心血管疾病的疾病。