公开(公告)号：KR101048152B1

公开(公告)日：2011-07-11

申请号：KR1020100036287

申请日：2010-04-20

Applicant: 강원대학교산학협력단 ,  화인코주식회사

Inventor： 김진철 ,  임건빈 ,  최재형 ,  이미선 ,  강미경

IPC: A61K9/06 ,  A61K47/40 ,  C08B37/16

CPC classification number: A61K47/6951 ,  A61K9/06 ,  A61K47/42 ,  A61K2121/00

Abstract: PURPOSE: A cyclo dextrin hydrogel containing hydrophobic fibroin and a method for preparing the same are provided to actively release wound healing drug to the outside. CONSTITUTION: A cyclo dextrin hydrogel contains hydrophobic fibroin. The cyclo dextrin hydrogel is prepared by cross-linking cyclo dextrin. The dextrin is selected from alpha-cyclo dextrin, beta-cyclo dextrin, and gamma-cyclo dextrin. The hydrophobic fibroin is fixed inside the cyclo dextrin hydrogel. The hydrophobic fibroin is formed by covalent bond of carbon chains.

Abstract translation: 目的：提供含有疏水性丝心蛋白的环糊精水凝胶及其制备方法，以向外界主动释放伤口愈合药物。 构成：环糊精水凝胶含有疏水性丝心蛋白。 环糊精水凝胶通过交联环糊精制备。 糊精选自α-环糊精，β-环糊精和γ-环糊精。 疏水性丝心蛋白固定在环糊精水凝胶内。 疏水性丝心蛋白由碳链的共价键形成。

公开(公告)号：KR101055803B1

公开(公告)日：2011-08-09

申请号：KR1020100108693

申请日：2010-11-03

Applicant: 강원대학교산학협력단

Inventor： 김진철 ,  임건빈 ,  이미선

IPC: C08F261/04 ,  C08F251/00 ,  C08F16/06 ,  C08J3/075

CPC classification number: C08F261/04 ,  A61K47/6951 ,  C08F251/00 ,  C08J3/075 ,  C08J3/24

Abstract: PURPOSE: A cyclodextrin/poly(vinyl alcohol) hydrogel is provided to emit relatively many target materials through the ionization of basic(acidic) hydrophobic compounds in an acidic(basic) aqueous solution and to relatively emit relatively a few target materials through the formation of a salt bridge of the acidic hydrophobic compound and the basic hydrophobic compound in a neutral aqueous solution. CONSTITUTION: A method for preparing a cyclodextrin/poly(vinyl alcohol) hydrogel comprises the steps of: (i) adding a crosslinking agent to the mixed liquid of cyclodextrin and poly(vinyl alcohol); (ii) dipping a mixed suspension consisting of a hydrophobic compound having acidic groups and a hydrophobic compound having basic groups to allow the hydrophobic compounds having acidic groups and basic groups to form an inclusion complex in the hydrophobic cavity of the hydrogel; and (iii) mixing the hydrogel with a hydrophilic target material aqueous solution to load the hydrophilic target material on the hydrogel.

Abstract translation: 目的：提供环糊精/聚（乙烯醇）水凝胶，通过在酸性（碱性）水溶液中离子化碱性（酸性）疏水性化合物，通过形成相对较少的靶物质 酸性疏水性化合物的盐桥和碱性疏水化合物在中性水溶液中。 构成：制备环糊精/聚（乙烯醇）水凝胶的方法包括以下步骤：（i）向环糊精和聚（乙烯醇）的混合液中加入交联剂; （ii）浸渍由具有酸性基团的疏水性化合物和具有碱性基团的疏水性化合物组成的混合悬浮液，以使具有酸性基团和碱性基团的疏水性化合物在水凝胶的疏水空腔中形成包合络合物; 和（iii）将水凝胶与亲水性目标材料水溶液混合，以将亲水性目标材料负载在水凝胶上。

公开(公告)号：KR1020120132145A

公开(公告)日：2012-12-05

申请号：KR1020110050791

申请日：2011-05-27

Applicant: 강원대학교산학협력단

Inventor： 김진철 ,  이미선 ,  서희진

IPC: C08J3/075 ,  C08J3/24 ,  C08L101/02 ,  A61K47/30

Abstract: PURPOSE: A photoresponsive hydrogel is provided to control the emission of light under 260 nm by reducing the cross-linking density of hydrogel by irradiating with a light in 260 nm or less, or increasing the cross-linked density by irradiating with a light in 310 nm or more. CONSTITUTION: A photoresponsive hydrogel is formed by photocrosslinking an aqueous polymer combined with photocrosslinking the water-aqueous polymer combined with a coumarin derivative, and can control the emission of water-soluble target material by photo-irradiation. A manufacturing method of the photosensitive hydrogel comprises: a step of binding a coumarin derivative to an aqueous polymer; a step of manufacturing hydrogel by photo-crosslinking an aqueous polymer solution combined with a coumarin derivative, and a step of mounting a hydrophilic target material to the hydrogel.

Abstract translation: 目的：提供光响应性水凝胶，通过用260nm或更小的光照射降低水凝胶的交联密度，或通过在310中照射光来增加交联密度来控制260nm以下的光的发射 nm以上。 构成：光反应性水凝胶是通过将与水凝胶与香豆素衍生物结合的水性聚合物结合的水性聚合物进行光交联而形成的，并且可以通过光照照射来控制水溶性目标物质的发射。 感光性水凝胶的制造方法包括：将香豆素衍生物与水性聚合物结合的工序; 通过光聚合与香豆素衍生物组合的聚合物水溶液进行光交联制造水凝胶的步骤，以及将亲水性靶材料安装在水凝胶上的步骤。