公开(公告)号：KR101025160B1

公开(公告)日：2011-03-31

申请号：KR1020100037797

申请日：2010-04-23

Applicant: 강원대학교산학협력단

Inventor： 조재열 ,  이사빈 ,  이강준 ,  안효민 ,  유대성 ,  변세은

IPC: A61K31/56 ,  A61K31/015 ,  A61P29/00 ,  A61P37/00

CPC classification number: A61K31/56 ,  A61K31/122 ,  A61K31/575 ,  A61K2300/00 ,  Y10S514/885 ,  Y10S514/886

Abstract: PURPOSE: A composition for anti-inflammation and immunity regulation is provided to suppress expression of TNF-alpha and prostaglandin(PGE2) and to teat inflammatory diseases. CONSTITUTION: A composition for anti-inflammation and enhancing immunity contains trisnorhopanone, campesterol, and diplopterol as an active ingredient. The active ingredient suppresses NO generation and TNF-alpha generation. The active ingredient further contains dryocrassin, dryocrassol, dryocrassyl acetate, fernene, or flavaspidic acid.

Abstract translation: 目的：提供抗炎和免疫调节的组合物，以抑制TNF-α和前列腺素（PGE2）的表达和乳头炎。 构成：用于抗炎和增强免疫的组合物含有三羟甲喋呤，菜油甾醇和diplopterol作为活性成分。 活性成分抑制NO产生和TNF-α产生。 活性成分进一步含有干甘油三酯，干甘油三酯，醋酸干甘油酯，蕨类或黄烷酸。

公开(公告)号：KR1020110128068A

公开(公告)日：2011-11-28

申请号：KR1020100047683

申请日：2010-05-20

Applicant: 강원대학교산학협력단

Inventor： 조재열 ,  이용규 ,  변세은 ,  김민호 ,  유대성 ,  이송이 ,  이강준 ,  안효민 ,  이사빈

IPC: A61K36/185 ,  A61P29/00 ,  A23L33/00 ,  A23L1/30

Abstract: PURPOSE: A composition containing Hopea odorata Roxb. extract with anti-inflammation is provided to control macrophage function and to prevent and treat acure/chronic inflammation immunity and autoimmune response. CONSTITUTION: A pharmaceutical composition contains Hopea odorata Roxb. extract as an active ingredient. The extract is isolated using methanol, ethanol, or water. The extract is prepared by isolating Hopea odorata Roxb. with ethanol, suspending with water, and fractioning with n-hexane, ethyl acetate, and n-butanol. The extract is prepared in the form of a carrier, excipient, or diluent. The extract suppresses NO generation and pro-inflammatory cytokines(IL-6, GM-CSF, IL-1β and TNF-alpha). A neutraceutical food contains the hot water extract of Hopea odorata Roxb. as an active ingredient.

Abstract translation: 目的：含有Hopea odorata Roxb的组合物。 提供具有抗炎作用以控制巨噬细胞功能并预防和治疗急性/慢性炎症免疫和自身免疫应答。 组成：药物组合物含有Hopea odorata Roxb。 提取物作为活性成分。 使用甲醇，乙醇或水分离提取物。 提取物通过分离Hopea odorata Roxb制备。 用乙醇悬浮，用正己烷，乙酸乙酯和正丁醇分级。 提取物以载体，赋形剂或稀释剂的形式制备。 提取物抑制NO产生和促炎细胞因子（IL-6，GM-CSF，IL-1β和TNF-α）。 一种中性食品含有Hopea odorata Roxb的热水提取物。 作为活性成分。

公开(公告)号：KR100992601B1

公开(公告)日：2010-11-08

申请号：KR1020100037610

申请日：2010-04-22

Applicant: 강원대학교산학협력단

Inventor： 조재열 ,  이사빈 ,  이강준 ,  안효민 ,  김민호 ,  이송이

IPC: A61K36/12 ,  A61P29/00 ,  A61P37/00

Abstract: PURPOSE: A Dryopteris Crassirhizoma extract with activity of anti-inflammation and immunity regulation is provided to suppress expression and generation of TNF-alpha and prostaglandin. CONSTITUTION: A composition for anti-inflammation and immunity regulation contains Dryopteris Crassirhizoma extract as an active ingredient. The Dryopteris Crassirhizoma extract suppresses NO generation. The composition contains 12.5 ug/ml or more of Dryopteris Crassirhizoma extract as an active ingredient.

Abstract translation: 目的：提供具有抗炎和免疫调节活性的鳞翅目提取物以抑制TNF-α和前列腺素的表达和产生。 构成：用于抗炎和免疫调节的组合物含有鳞翅目提取物作为活性成分。 Dry藜提取物抑制NO产生。 该组合物含有12.5μg/ ml以上的鳞翅目提取物作为活性成分。