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公开(公告)号：KR100891545B1
公开(公告)日：2009-04-03
申请号：KR1020070081953
申请日：2007-08-14
Applicant: 강원대학교산학협력단
Abstract: 본 발명은 소수화된 폴리이소프로필아크릴아미드(Poly(
N -isopropylacrylamide); PNIPAM)가 큐빅상 내부의 수상채널에 고정화되어 제조된 모노올레인 큐빅상(monoolein cubic phase)에 관한 것으로, 폴리이소프로필아크릴아미드의 상전이 온도 이하에서는 포집 성분을 비교적 적게 방출하고, 상전이 온도 이상에서는 포집 성분을 비교적 많이 방출할 수 있는바, 목적 물질을 필요에 따라 조건의 조절을 통해, 포집 상태를 유지할 수도, 방출할 수도 있는 특징이 있다.
모노올레인, 상전이, 포집, 폴리이소프로필아크릴아미드, 큐빅상,-
公开(公告)号：KR1020090017309A
公开(公告)日：2009-02-18
申请号：KR1020070081952
申请日：2007-08-14
Applicant: 강원대학교산학협력단
IPC: A61K9/16
CPC classification number: A61K47/24 , A61K9/1611 , A61K9/1617 , A61K9/1682 , A61K47/02
Abstract: An alginate particle containing calcium carbonate in matrix is provided to selectively release the various hydrophobic and hydrophilic physiological ingredients within the particle by releasing the relatively small amount of target material encapsulated at basic pH and the relatively large amount of target material encapsulated at acidic pH. The alginate particle contains calcium carbonate in alginate matrix, and is prepared by mixing solution or suspension containing alginate and the target material with solution or suspension containing calcium carbonate to prepare calcium carbonate-alginate mixed solution, and adding droplet of or spraying the calcium carbonate-alginate mixed solution into multivalent cation solution.
Abstract translation: 提供含有基质中碳酸钙的藻酸盐颗粒，通过释放在碱性pH下包封的相对少量的目标物质和在酸性pH下包封的相对大量的目标物质来选择性地释放颗粒内的各种疏水和亲水的生理成分。 藻酸盐颗粒在藻酸盐基质中含有碳酸钙，并且通过将含有藻酸盐的溶液或悬浮液与目标材料与含有碳酸钙的溶液或悬浮液混合以制备碳酸钙 - 藻酸盐混合溶液，并加入或喷洒碳酸钙 - 藻酸盐混合溶液成多价阳离子溶液。
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公开(公告)号：KR100891548B1
公开(公告)日：2009-04-03
申请号：KR1020070140201
申请日：2007-12-28
Applicant: 강원대학교산학협력단
IPC: C08F220/52 , C08F220/00 , C08K3/00
CPC classification number: C08F218/02 , C08F2/44 , C08F8/32 , C08F220/56 , C08J3/091 , C08J3/12
Abstract: An alginate particle containing poly(N-isopropylacrylamide) is provided to emit a relatively small amount of capture target materials below Tg of poly(N-isopropylacrylamide) and emit a relatively large amount of the capture target materials above the Tg of poly(N-isopropylacrylamide). A method for preparing an alginate particle having capture target materials comprises the following steps of: melting or dispersing capture target materials in a liquid or colloidal suspension containing a copolymer of poly(N-isopropylacrylamide) and alginate; and dropping or spraying the liquid or colloidal suspension in a solution with Ca^(2+), Mg^(2+), Al^(3+), Cr^(3+). The copolymer of poly(N-isopropylacrylamide) and alginate is prepared by reacting a NH2 group to poly(N-isopropylacrylamide) and then condensation-reacting the poly(N-isopropylacrylamide) to a carboxyl group of the alginate.
Abstract translation: 提供含有聚（N-异丙基丙烯酰胺）的藻酸盐颗粒以在聚（N-异丙基丙烯酰胺）Tg以下发射相对少量的捕获目标材料，并在聚（N-异丙基丙烯酰胺）的Tg以上发射相对大量的捕获目标材料， 异丙基丙烯酰胺）。 制备具有捕获目标材料的藻酸盐颗粒的方法包括以下步骤：将捕获目标材料熔融或分散在含有聚（N-异丙基丙烯酰胺）和藻酸盐的共聚物的液体或胶态悬浮液中; 并将液体或胶体悬浮液滴入或喷雾于含Ca（2+），Mg（2+），Al（3+），Cr（3+）的溶液中。 通过使NH 2基团与聚（N-异丙基丙烯酰胺）反应，然后使聚（N-异丙基丙烯酰胺）与藻酸盐的羧基缩合反应来制备聚（N-异丙基丙烯酰胺）和藻酸盐的共聚物。
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Patent Agency Ranking
公开(公告)号：KR1020100041616A
公开(公告)日：2010-04-22
申请号：KR1020080100881
申请日：2008-10-14
Applicant: 강원대학교산학협력단
CPC classification number: C08J3/24 , A61K9/1075 , A61K47/30
Abstract: PURPOSE: A polymeric micelle having a salt bridge and a method for preparing the same are provided to quickly and selectively release a target material at acidic and alkaline pH concentrations. CONSTITUTION: A polymeric micelle collecting target materials is formed by a salt bridge between aqueous polymer having acidic group and amphiphilic molecule having an alkaline group. The polymeric micelle having the salt bridge is obtained by mixing the aqueous polymer, amphiphilic molecule and target material on an aqueous phase of which pK value is higher than that of the aqueous polymer and is lower than that of the amphiphilic molecule. The acidic group is carboxyl group, sulfonic group, or phosphate group.
Abstract translation: 目的：提供具有盐桥的聚合物胶束及其制备方法，以在酸性和碱性pH浓度下快速且选择性地释放靶材料。 构成：通过具有酸性基团的水性聚合物和具有碱性基团的两亲性分子之间的盐桥形成聚合物胶束收集目标材料。 具有盐桥的聚合物胶束通过将水性聚合物，两亲性分子和靶材料混合在pK值高于含水聚合物的水相上并且低于两亲性分子的水相而获得。 酸性基团是羧基，磺酸基或磷酸基。
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公开(公告)号：KR1020090017310A
公开(公告)日：2009-02-18
申请号：KR1020070081953
申请日：2007-08-14
Applicant: 강원대학교산학협력단
CPC classification number: A61K47/595 , A61K9/146 , A61K47/6903
Abstract: A poly(N-isopropylacrylamide)-immobilized monoolein cubic phase is provided to release the relatively small amount of the target ingredient at less than phase transition temperature of poly(N-isopropylacrylamide), and release the relatively large amount of the target ingredient at more than phase transition temperature of poly(N-isopropylacrylamide). The poly(N-isopropylacrylamide)-immobilized monoolein cubic phase is manufactured by mixing polyisopropylamide combined with immobilizing material to be immobilized to the aqueous channel within the cubic phase with the target material to be encapsulated into the aqueous channel to prepare the mixed solution; and adding the mixed solution into the monoolein-dissolved solution to form the transparent gel.
Abstract translation: 提供聚（N-异丙基丙烯酰胺） - 单油酸酯立方相以在聚（N-异丙基丙烯酰胺）的低于相变温度下释放相对少量的目标成分，并且在更多的情况下释放相对大量的目标成分 比聚（N-异丙基丙烯酰胺）的相变温度高。 聚（N-异丙基丙烯酰胺） - 单油酸酯立方相是通过将待固定的固定化物质的聚异丙基酰胺与立方相中的水溶液混合，将待包封的目标材料混合到水溶液中制备混合溶液; 并将混合溶液加入溶解于单油溶胶中以形成透明凝胶。
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公开(公告)号：KR101004709B1
公开(公告)日：2011-01-04
申请号：KR1020070140200
申请日：2007-12-28
Applicant: 강원대학교산학협력단
Abstract: 본 발명은 글루코스 산화효소(Glucose Oxidase, 이하 GOD)가 고정화된 베시클 및 그 제조방법에 관한 것으로, 본 발명의 베시클은 외부 표면에 글루코스 산화효소가 고정화되어 있기 때문에 베시클이 혈액 또는 그 외 글루코스를 함유하는 용액 중에 주입되었을 때, 혈액 또는 용액 중의 글루코스를 산화시켜 글루콘산(gluconic acid)을 생성시키는데, 글루콘산이 생성되면 베시클 주변의 pH는 낮아져 산성이 되고, 이로 말미암아 베시클은 파괴되며, 그 내부에 봉입되어 있는 목적물질은 외부로 방출되는 특징이 발휘된다.
고정화, 글루코스 산화효소, 베시클, 선택적, 식품, 의약,-
公开(公告)号：KR100919508B1
公开(公告)日：2009-09-28
申请号：KR1020070081952
申请日：2007-08-14
Applicant: 강원대학교산학협력단
IPC: A61K9/16
Abstract: 본 발명은 목적물질을 포집하고 있는 알지네이트(alginate) 입자의 매트릭스에 칼슘 카보네이트(calcium carbonate)를 함유시킴으로써, 염기성 pH에서 목적물질을 비교적 적게 방출하고, 산성 pH에서 목적물질을 비교적 많이 방출하는 특징이 있다.
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公开(公告)号：KR1020090072170A
公开(公告)日：2009-07-02
申请号：KR1020070140200
申请日：2007-12-28
Applicant: 강원대학교산학협력단
CPC classification number: A61K9/127 , A61K38/443 , A61K47/42
Abstract: A vesicle which glucose oxidase (GOD) is fixed is provided to deliver target material in an expected concentration without loss of blood and solution by selectively crushing the vesicle in solution containing blood or glucose. A vesicle which has a spherical form by amphipathic molecule and contains a target material inside comprises a glucose oxidase fixed on the outer surface. The amphipathic molecule is dioleoylphosphatidylethanolamine(DOPE). The hydrophobic anchor is palmitic acid N-hydroxysuccinimide ester. A method for manufacturing the vesicle comprises: a step of producing suspension after adding amphipathic molecule in a solution containing target material and dispersion agent; a step of homogenizing suspension solution with sonication, microfluidizer or membrane extrusion; and a step of removing the dispersion agent using gel chromatography or dialysis.
Abstract translation: 提供固定葡萄糖氧化酶（GOD）的囊泡以通过在含有血液或葡萄糖的溶液中选择性压碎囊泡而以预期浓度输送目标物质而不损失血液和溶液。 通过两亲性分子具有球形形式并含有靶物质的囊泡包含固定在外表面上的葡萄糖氧化酶。 两亲性分子是二油酰磷脂酰乙醇胺（DOPE）。 疏水锚是棕榈酸N-羟基琥珀酰亚胺酯。 囊泡的制造方法包括：在含有靶物质和分散剂的溶液中加入两亲性分子后制备悬浮液的步骤; 用超声处理，微流化器或膜挤出均质悬浮液的步骤; 以及使用凝胶色谱法或透析法除去分散剂的步骤。
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