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公开(公告)号：KR101360315B1
公开(公告)日：2014-02-12
申请号：KR1020120068455
申请日：2012-06-26
Applicant: 강원대학교산학협력단
Abstract: 본 발명은 산화철 나노 입자 (ion oxide nanoparticles)를 큐빅상에 제조하고, 그 큐빅상을 수상에서 균질화시켜 제조된 산화철 나노입자가 로딩된 큐빅상 나노입자에 관한 것으로서, 그 큐빅상 나노입자는 자성을 나타내는 특징이 있다.
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公开(公告)号：KR100905387B1
公开(公告)日：2009-06-30
申请号：KR1020080097396
申请日：2008-10-02
Applicant: 강원대학교산학협력단
Abstract: A composition of solvent extract from Berberis koreana Palibin is provided to suppress the generation of nitric oxide, TNF-alpha and prostaglandin E2(PGE2) and regulates the function of macrophage. A method for manufacturing a butanol fraction of Berberis koreana Palibin comprises: a step of extracting the Berberis koreana Palibin in the water of 20-100°C to obtain concentrate; a step of suspending the concentrate with water and a step of fraction-extracting the suspension with hexane, ethylacetate and butanol. A pharmaceutical composition for treating inflammatory disease or immune-modulating comprises the butanol fraction of water extract of Berberis koreana Palibin. The inflammatory disease is arthritis, the sepsis, and inflammation or the autoimmune disease.
Abstract translation: 提供小檗碱溶剂提取物的组合物，以抑制一氧化氮，TNF-α和前列腺素E2（PGE2）的产生并调节巨噬细胞的功能。 一种制备小檗的丁醇馏分的方法包括：在20-100℃的水中提取小檗Berberin获得浓缩物的步骤; 用水悬浮浓缩物的步骤和用己烷，乙酸乙酯和丁醇分馏提取悬浮液的步骤。 用于治疗炎性疾病或免疫调节的药物组合物包含小檗Berberis水提取物的丁醇级分。 炎性疾病是关节炎，败血症，炎症或自身免疫性疾病。
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公开(公告)号：KR1020140077483A
公开(公告)日：2014-06-24
申请号：KR1020120146340
申请日：2012-12-14
Applicant: 강원대학교산학협력단
IPC: A61K36/234 , A61P9/10 , A61P9/00
Abstract: The present invention relates to a composition for prevention or alleviation of ischemic cerebrovascular diseases comprising a Glehnia littoralis extract as an active ingredient. The composition comprising the Glehnia littoralis extract as an active ingredient can effectively inhibit apoptosis of nerve cells in brain tissue and also inhibit abnormal activation of neuroglial cells, and thus can be variously applied for prevention, alleviation, or treatment of cerebrovascular diseases.
Abstract translation: 本发明涉及一种用于预防或缓解缺血性脑血管疾病的组合物，其包含小叶提取物作为活性成分。 作为活性成分的洛氏提取物的组合物能够有效地抑制脑组织中的神经细胞的凋亡，并且能够抑制神经胶质细胞的异常活化，可以各种应用于预防，缓解或治疗脑血管疾病。
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公开(公告)号：KR1020130125488A
公开(公告)日：2013-11-19
申请号：KR1020120049036
申请日：2012-05-09
Applicant: 강원대학교산학협력단
CPC classification number: A61K47/40 , A61K9/06 , A61K31/765 , A61K41/00 , A61K2121/00
Abstract: The present invention relates to photoresponsive microgel. Particularly, the present invention relates to photoresponsive microgel which is a microgel formed by hydrophobic interaction between a photoresponsive surfactant and cyclodextrin polymers. When the microgel is irradiated by light, the size and the crosslinking degree of the microgel are sharply changed by dimerization or de-dimerization of the photoresponsive surfactant.
Abstract translation: 本发明涉及光响应微凝胶。 特别地，本发明涉及光响应性微凝胶，其是通过光响应性表面活性剂与环糊精聚合物之间的疏水相互作用形成的微凝胶。 当光照射微凝胶时，微粒凝胶的尺寸和交联度通过光响应性表面活性剂的二聚化或去二聚作用而急剧变化。
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公开(公告)号：KR1020120066369A
公开(公告)日：2012-06-22
申请号：KR1020100127677
申请日：2010-12-14
Applicant: 강원대학교산학협력단
CPC classification number: A61K9/16 , A61K47/6949 , C08J3/075 , C08J3/242
Abstract: PURPOSE: A chitosan microgel for inclusion of a target material is provided to control release of the target matetial by responding to pH change. CONSTITUTION: A chitosan microgel contains chitosan which is crosslinked with gluta aldehyde, formaldehyde, or dextrin aldehyde. A method for preparing the chitosan microgel comprises: a step of dissolving the chitosan in an acid solution to prepare a chitosan solution; a step of adding a crosslinking agent of gluta aldehyde, formaldehyde, or dextrin aldehyde into the chitosan solution; a step of spray-drying a mixture solution of chitosan and crosslinking agent to prepare crosslinked chitosan microgel; and a step of loading the target material on the chitosan microgel.
Abstract translation: 目的：提供用于包含靶材料的壳聚糖微凝胶，以通过响应pH变化来控制靶物质的释放。 构成：壳聚糖微凝胶含有与谷氨醛，甲醛或糊精醛交联的壳聚糖。 制备壳聚糖微凝胶的方法包括：将壳聚糖溶解在酸溶液中以制备壳聚糖溶液的步骤; 将谷氨醛，甲醛或糊精醛交联剂加入到壳聚糖溶液中的步骤; 喷雾干燥壳聚糖和交联剂的混合溶液以制备交联的壳聚糖微凝胶的步骤; 以及将目标材料装载在壳聚糖微凝胶上的步骤。
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Patent Agency Ranking
公开(公告)号：KR1020100041616A
公开(公告)日：2010-04-22
申请号：KR1020080100881
申请日：2008-10-14
Applicant: 강원대학교산학협력단
CPC classification number: C08J3/24 , A61K9/1075 , A61K47/30
Abstract: PURPOSE: A polymeric micelle having a salt bridge and a method for preparing the same are provided to quickly and selectively release a target material at acidic and alkaline pH concentrations. CONSTITUTION: A polymeric micelle collecting target materials is formed by a salt bridge between aqueous polymer having acidic group and amphiphilic molecule having an alkaline group. The polymeric micelle having the salt bridge is obtained by mixing the aqueous polymer, amphiphilic molecule and target material on an aqueous phase of which pK value is higher than that of the aqueous polymer and is lower than that of the amphiphilic molecule. The acidic group is carboxyl group, sulfonic group, or phosphate group.
Abstract translation: 目的：提供具有盐桥的聚合物胶束及其制备方法，以在酸性和碱性pH浓度下快速且选择性地释放靶材料。 构成：通过具有酸性基团的水性聚合物和具有碱性基团的两亲性分子之间的盐桥形成聚合物胶束收集目标材料。 具有盐桥的聚合物胶束通过将水性聚合物，两亲性分子和靶材料混合在pK值高于含水聚合物的水相上并且低于两亲性分子的水相而获得。 酸性基团是羧基，磺酸基或磷酸基。
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公开(公告)号：KR1020140003730A
公开(公告)日：2014-01-10
申请号：KR1020120068455
申请日：2012-06-26
Applicant: 강원대학교산학협력단
Abstract: The present invention relates to cubic phase nanoparticles in which iron oxide nanoparticles are loaded. The iron oxide nonoparticles are produced on a cubic phase, and the cubic phase nanoparticles loaded with the iron oxide nanoparticles are produced by homogenizing the cubic phase in water. The cubic phase nanoparticles exhibit magnetism.
Abstract translation: 本发明涉及载有氧化铁纳米粒子的立方相纳米粒子。 在立方相上制备氧化铁非颗粒，并且通过在水中均化立方相来制备负载有氧化铁纳米颗粒的立方相纳米颗粒。 立方相纳米颗粒表现出磁性。
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公开(公告)号：KR1020130021246A
公开(公告)日：2013-03-05
申请号：KR1020110083646
申请日：2011-08-22
Applicant: 강원대학교산학협력단
IPC: A61K31/37 , A61K31/195 , A61K31/185 , A61K47/48
CPC classification number: A61K31/37 , A61K47/62 , A61K2121/00
Abstract: PURPOSE: A self-assembly of a coumarin-proteinoid conjugate, and a method for preparing the same are provided to control the release of a water soluble target material. CONSTITUTION: A self-assembly of a coumarin-proteinoid conjugate is prepared by dispersing the coumarin-proteinoid conjugate in an aqueous phase. The coumarin-proteinoid conjugate is prepared by a chemical bond of a coumarin derivative and proteinoid. The coumarin derivative is 7-hydroxy coumarin or epoxypropoxy coumarin.
Abstract translation: 目的：提供香豆素 - 类蛋白结合物的自组装及其制备方法以控制水溶性靶物质的释放。 构成：通过将香豆素 - 类似蛋白偶联物分散在水相中制备香豆素 - 类似物缀合物的自组装。 香豆素 - 类似蛋白偶联物通过香豆素衍生物和类蛋白酶的化学键制备。 香豆素衍生物为7-羟基香豆素或环氧丙氧基香豆素。
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公开(公告)号：KR1020110100857A
公开(公告)日：2011-09-15
申请号：KR1020100019912
申请日：2010-03-05
Applicant: 강원대학교산학협력단
CPC classification number: A61K47/36 , A61K9/5021 , A61K9/5089 , A61K47/02 , A61K47/06
Abstract: 본 발명은 목적물질을 함유하는 알지네이트 미세입자와, 칼슘 카보네이트 미세입자를 캡슐 내부에 함유하고; 캡슐 벽은, 계면활성제와 알코올에 용해되지 않는 고분자로 이루어진 것을 특징으로 하는 마이크로 캡슐 및 그의 제조방법에 관한 것으로, 본 발명의 마이크로 캡슐은 알코올 수용액 및 계면활성제의 기제에 대해서 안정하고, 낮은 pH에서는 목적 물질을 비교적 적게 방출하고 높은 pH에서는 목적물질을 비교적 많이 방출하는 특징을 나타내기 때문에 pH 변화에 따라 방출하는 목적물질의 양을 조절할 수 있는바, 내부에 포집된 항암제, 항생제, 항진균제, 항박테리아제, 항산화제, 미백제, 소염제 등의 다양한 소수성, 친수성 생리활성 성분을 필요한 상황에 따라 선택적으로 외부에 방출시킬 수 있는 효과를 발휘한다.
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公开(公告)号：KR101400964B1
公开(公告)日：2014-05-30
申请号：KR1020120096072
申请日：2012-08-31
Applicant: 강원대학교산학협력단
Abstract: 본 발명은 pH 변화에 따른 포접물질의 방출성이 민감한 산성 베시클 및 그의 제조방법에 관한 것으로, 시나믹산과 산성 프로테노이드가 수식된 본 발명의 산성 베시클은 특정한 pH 범위에서 베시클 내부에 포접된 물질을 비교적 많이 방출할 뿐만 아니라, pH 민감성이 매우 높은 특징이 있다.
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