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1.发明公开
公开(公告)号：KR1020140019185A
公开(公告)日：2014-02-14
申请号：KR1020120085912
申请日：2012-08-06
Applicant: 강원대학교산학협력단 , 서원대학교산학협력단
Abstract: The present invention relates to a cosmetic composition comprising Acer okamotoanum Nakai sap treated at an ultrahigh pressure and a manufacturing method thereof and more particularly, to Acer okamotoanum Nakai extract having anti-inflammatory effects and anti-atopic effects, which is treated at a low temperature of 25°C and a ultrahigh pressure of 300 to 500 MPa for 15 to 35 minutes, a functional cosmetic composition comprising the extract as an active ingredient and a manufacturing method thereof. The Acer okamotoanum Nakai extract treated at a low temperature and an ultrahigh pressure according to the present invention has enhanced storability because the growth of microorganisms contained in the extract is inhibited owing to the conducted ultrahigh pressure process, and reduces the loss and inactivity of useful bio-active substances contained in Acer okamotoanum Nakai, which is induced by a high temperature, owing to the treatment at a low temperature. Also the cosmetic composition comprising the Acer okamotoanum Nakai sap, which is manufactured by the method according to the present invention, as an active ingredient is safe in a long-term usage owing to the used natural materials and has no toxicity and no side effect. And the present invention can be useful in manufacturing functional cosmetics owing to the excellent effects of inhibiting inflammation and alleviating and treating atopy. [Reference numerals] (AA) Acer okamotoanum Nakai sap; (BB) Ultrahigh-pressure Acer okamotoanum Nakai sap; (CC) Acer mono sap; (DD) Ultrahigh-pressure Acer mono sap
Abstract translation: 本发明涉及一种包含在超高压下处理的中华猕猴桃汁和其制造方法的化妆品组合物，更具体地说，涉及具有抗炎作用和抗特应性作用的宏碁提取物，其在低温下处理 25℃，超高压300〜500MPa，15〜35分钟的功能化妆品组合物，其特征在于，含有提取物作为有效成分的功能性化妆品及其制造方法。 根据本发明处理的在低温和超高压下处理的Acer okamotoanum Nakai提取物具有增强的保存性，因为由于进行的超高压工艺，包含在提取物中的微生物的生长被抑制，并且减少了有用生物的损失和不活动 由于在低温下处理，由高温引起的Acer okamotoanum Nakai中含有的活性物质。 另外，通过本发明的方法制造的含有Acer okamotoanum Nakai sap的化妆品组合物作为活性成分，由于使用的天然材料而在长期使用中是安全的，并且没有毒性并且没有副作用。 本发明由于抑制炎症和减轻和治疗特应症的优异效果，可用于制造功能性化妆品。 [参考数字]（AA）Acer okamotoanum Nakai sap; （BB）超高压宏碁中ai汁; （CC）宏碁单汁液; （DD）超高压宏碁单汁液
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公开(公告)号：KR1020210042226A
公开(公告)日：2021-04-19
申请号：KR1020190124898
申请日：2019-10-08
Applicant: 강원대학교산학협력단
Abstract: 본발명의산화반응성모노올레인큐빅상은양친성성질을가지는히드록시아크릴아미드단위체와페닐비닐황화물단위체의공중합체를포함한다. 상기공중합체는환원환경에서워터채널의이중층에고정되어존재하므로워터채널의확산을억제한다. 반면산화환경이되면상기공중합체가산화되어음의전하가상승하므로상기양친성성질이저하된다. 상기양친성성질의저하는상기공중합체가더 이상워터채널의이중층에고정되지않고워채널내로확산되도록하므로워터채널의확산이향상되어워터채널에탑재된물질이방출되게된다. 따라서본 발명의산화반응성모노올레인큐빅상은산화환경에서특이적으로워터채널에탑재한물질을방출하는효과가있다.
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公开(公告)号：KR102220162B1
公开(公告)日：2021-02-24
申请号：KR1020190052143
申请日：2019-05-03
Applicant: 강원대학교산학협력단
Abstract: 본발명의피부및 체내유효성분전달을위한화장품소재용모노올레인(monooleion) 나노구조체는다당류-이황화화합물복합체를워터채널내부에포함하는모노올레인큐빅상이다. 상기다당류-이황화화합물복합체는모노올레인이중층에삽입된스테릴트리메틸암모늄클로라이드과결합되어상기워터채널에고정되므로다당류또는이황화화합물의개질없이도안정적인고정이가능한장점이있다. 또한상기다당류-이황화화합물복합체는체외환경에서생리활성물질과의정전기적상호결합과이황화화합물의이황화결합으로형성된 3차원네트워크를통해생리활성물질을확산없이안전하게보관할수 있는장점이있으며체내환경에서는상기정전기적상호결합및 이황화결합이제거되어상기생리활성물질이확산되어방출되는특징이있다. 본발명의피부및 체내유효성분전달을위한화장품소재용모노올레인(monooleion) 나노구조체는지질이중층으로구성되어경피흡수성능이우수할뿐 아니라표피층에도포시에는생리활성물질을방출하지않고있다가표피층내부로흡수되어체내환경에위치해야만생리활성물질이제어방출되는특징이있다. 따라서본 발명의피부및 체내유효성분전달을위한화장품소재용모노올레인나노구조체는아무런인위적인자극없이도체내환경에능동적으로대응하여생리활성물질을제어방출할 수있는기능성화장품용약물전달체로서사용가능한장점이있다.
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公开(公告)号：KR1020200127633A
公开(公告)日：2020-11-11
申请号：KR1020190052143
申请日：2019-05-03
Applicant: 강원대학교산학협력단
Abstract: 본발명의피부및 체내유효성분전달을위한화장품소재용모노올레인(monooleion) 나노구조체는다당류-이황화화합물복합체를워터채널내부에포함하는모노올레인큐빅상이다. 상기다당류-이황화화합물복합체는모노올레인이중층에삽입된스테릴트리메틸암모늄클로라이드과결합되어상기워터채널에고정되므로다당류또는이황화화합물의개질없이도안정적인고정이가능한장점이있다. 또한상기다당류-이황화화합물복합체는체외환경에서생리활성물질과의정전기적상호결합과이황화화합물의이황화결합으로형성된 3차원네트워크를통해생리활성물질을확산없이안전하게보관할수 있는장점이있으며체내환경에서는상기정전기적상호결합및 이황화결합이제거되어상기생리활성물질이확산되어방출되는특징이있다. 본발명의피부및 체내유효성분전달을위한화장품소재용모노올레인(monooleion) 나노구조체는지질이중층으로구성되어경피흡수성능이우수할뿐 아니라표피층에도포시에는생리활성물질을방출하지않고있다가표피층내부로흡수되어체내환경에위치해야만생리활성물질이제어방출되는특징이있다. 따라서본 발명의피부및 체내유효성분전달을위한화장품소재용모노올레인나노구조체는아무런인위적인자극없이도체내환경에능동적으로대응하여생리활성물질을제어방출할 수있는기능성화장품용약물전달체로서사용가능한장점이있다.
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Patent Agency Ranking
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公开(公告)号：KR1020180094647A
公开(公告)日：2018-08-24
申请号：KR1020170021049
申请日：2017-02-16
Applicant: 강원대학교산학협력단
Abstract: 본발명은양이온양친매성분자와음이온이황화물의이온결합결합으로형성된염다리결합체가수상에서자가결집하여형성된환원응답성소포체(reduction-responsive vesicle)에관한것으로서, 환원환경(reducing environment)에서소포체를구성하고있는이황화물의이황화결합이파괴되기때문에양이온양친매성분자와음이온이황화물로구성된소포체는불안정화되어서탑재된내용물을비교적많이방출하는특징이있다.
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公开(公告)号：KR20180012119A
公开(公告)日：2018-02-05
申请号：KR20160094975
申请日：2016-07-26
Applicant: 강원대학교산학협력단
Abstract: 본발명은상한임계용액온도(upper critical solution temperature)를지닌염다리결합체 (salt bridge conjugate), 그리고염다리결합체를리포솜표면에고정화시킴으로써제조된온도응답성리포솜 (temperature-responsive liposome)에관한것으로서, 온도변화에응답하여내용물을방출하는특징이있다.
Abstract translation: 本发明涉及一种上限临界溶液温度（上限临界溶液温度）一盐桥缀合物（盐桥缀合物），和通过固定盐桥偶联至脂质体表面，温度变化制得的脂质体（温度响应脂质体）的温度响应 响应请求释放内容。
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公开(公告)号：KR101788610B1
公开(公告)日：2017-10-20
申请号：KR1020150141034
申请日：2015-10-07
Applicant: 강원대학교산학협력단
CPC classification number: A61K9/146
Abstract: 본발명은의약용단백질의지속방출을위한약물전달체에관한것으로, 본발명의약물전달체는의약용단백질의등전점이하 pH 값에서는양전하를띠는의약용단백질을정전기적인력으로효율적으로탑재시킬수 있고, 인체생리학적조건에서(pH 7.4, 37℃)는정전기적척력으로의약용단백질을배출하는데, 체온으로인하여응축된열 감응성고분자층 사이를통하여, 탑재된의약용단백질을서서히장기간지속방출시킬수 있다.
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公开(公告)号：KR1020170041509A
公开(公告)日：2017-04-17
申请号：KR1020150141034
申请日：2015-10-07
Applicant: 강원대학교산학협력단
CPC classification number: A61K9/146
Abstract: 본발명은의약용단백질의지속방출을위한약물전달체에관한것으로, 본발명의약물전달체는의약용단백질의등전점이하 pH 값에서는양전하를띠는의약용단백질을정전기적인력으로효율적으로탑재시킬수 있고, 인체생리학적조건에서(pH 7.4, 37℃)는정전기적척력으로의약용단백질을배출하는데, 체온으로인하여응축된열 감응성고분자층 사이를통하여, 탑재된의약용단백질을서서히장기간지속방출시킬수 있다.
Abstract translation: 本发明，并且本发明涉及一种药物递送系统，用于药用蛋白质的持续释放，sikilsu与药用蛋白是存在于本发明的药物递送系统是低于正通过静电吸引有效地充电的药用蛋白带的pH值的等电点的中， 在生理条件下（pH为7.4，37℃），以排出药用蛋白与neunjeong电排斥力，由于通过的热响应高分子层之间的缩合的体温，并且它sikilsu底座的长效蛋白药物缓慢释放。
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