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公开(公告)号：KR1020020085683A
公开(公告)日：2002-11-16
申请号：KR1020010025322
申请日：2001-05-09
Applicant: 강재선
IPC: A61K9/14
CPC classification number: A61K47/6949 , A61K9/0053 , A61K47/183 , A61K47/28 , A61K47/34 , A61K47/42 , A61K47/6929
Abstract: PURPOSE: A process of preparing a drug which is improved in dissolution and oral absorption characteristics by binding a drug which is unstable in the stomach and susceptible to disintegration during absorption to fine particles having a particle size of 10 to 12 μm, together with an absorption enhancer is provided which can prevent inconvenience and adverse side-effects associated with its use and increase bioavailability of drugs which cause its use value to degrade by the loss of activity when administered orally. CONSTITUTION: To improve biodegradability of salmon calcitonin, protein, peptide material and a drug, the drug is dissolved in a mixed solution of methanol, ethanol, acetone, isopropanol, etc. and then mixed with an absorption enhancer such as bile acid, bile salts, transferrin, folic acid, etc. and a biodegradable polymer. Thereafter, the mixed solution is dispersed in an aqueous solution, heated at 40deg.C for 1hr, centrifuged and dried.
Abstract translation: 目的：制备药物的制备方法，其通过将吸收期间不稳定并容易崩解的药物与粒径为10〜12μm的细颗粒结合使用，吸收改善了溶出度和口服吸收特性， 提供增强剂，其可以防止与其使用相关的不便和不良副作用，并增加药物的生物利用度，其通过口服给药时其活性丧失导致其使用价值降低。 构成：为了提高鲑鱼降钙素，蛋白质，肽材料和药物的生物降解能力，将药物溶解在甲醇，乙醇，丙酮，异丙醇等的混合溶液中，然后与吸收增强剂如胆汁酸，胆汁盐 ，转铁蛋白，叶酸等，以及可生物降解的聚合物。 此后，将混合溶液分散在40℃加热1小时的水溶液中，离心并干燥。
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公开(公告)号：KR100509843B1
公开(公告)日：2005-08-24
申请号：KR1020030016220
申请日：2003-03-14
IPC: A23L1/30
Abstract: 본 발명은 참당귀로부터 데커신 및 데커시놀 안젤레이트를 추출하는 방법에 관한 것으로, 더욱 상세하게는 한국이 원산지인 참당귀(
Angelica gigas, Nakai)를 이용하여 신장독성 경감 및 당뇨합병증에 따르는 신부전증의 억제효과, 당뇨성 고혈압에 효과를 보이는 참당귀 추출물을 함유하는 식품 및 약제학적 조성물을 제조하기 위하여 참당귀로부터 데커신 및 데커시놀 안젤레이트를 추출하는 방법에 관한 것이다.
이를 실현하기 위하여 본 발명은, 원료인 참당귀를 잘게 분쇄한 다음 분쇄한 참당귀에 에탄올을 첨가한 후 온도차이, 용해도 차이, 초음파기 또는 냉침방법을 이용하여 참당귀로부터 데커신 및 데커시놀 안젤레이트를 추출하는 것을 특징으로 한다.-
公开(公告)号：KR1020040080854A
公开(公告)日：2004-09-20
申请号：KR1020030016220
申请日：2003-03-14
IPC: A23L1/30
Abstract: PURPOSE: Provided are foods and pharmaceutical compositions containing Angelica gigas extract which are effective for alleviation of nephrotoxicity and diabetic hypertension. CONSTITUTION: The foods and pharmaceutical compositions containing Angelica gigas extract are characterized in that they are prepared by extracting and concentrating decursin and decursinol angelate contained in the Angelica gigas, Nakai to be formulated into an oral administration form such as tablet, capsule, liquid medicine and powdered form.
Abstract translation: 目的：提供含有当归猕猴提取物的食品和药物组合物，其有效缓解肾毒性和糖尿病高血压。 构成：含有当归提取物的食品和药物组合物的特征在于它们是通过提取和浓缩当归所含的当归的前胡素和当归酸，制成口服给药形式如片剂，胶囊，液体药物和 粉状
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