公开(公告)号：KR1020020085683A

公开(公告)日：2002-11-16

申请号：KR1020010025322

申请日：2001-05-09

Applicant: 강재선

Inventor： 강재선 ,  안병근 ,  전경동 ,  김원석 ,  이백천

IPC: A61K9/14

CPC classification number: A61K47/6949 ,  A61K9/0053 ,  A61K47/183 ,  A61K47/28 ,  A61K47/34 ,  A61K47/42 ,  A61K47/6929

Abstract: PURPOSE: A process of preparing a drug which is improved in dissolution and oral absorption characteristics by binding a drug which is unstable in the stomach and susceptible to disintegration during absorption to fine particles having a particle size of 10 to 12 μm, together with an absorption enhancer is provided which can prevent inconvenience and adverse side-effects associated with its use and increase bioavailability of drugs which cause its use value to degrade by the loss of activity when administered orally. CONSTITUTION: To improve biodegradability of salmon calcitonin, protein, peptide material and a drug, the drug is dissolved in a mixed solution of methanol, ethanol, acetone, isopropanol, etc. and then mixed with an absorption enhancer such as bile acid, bile salts, transferrin, folic acid, etc. and a biodegradable polymer. Thereafter, the mixed solution is dispersed in an aqueous solution, heated at 40deg.C for 1hr, centrifuged and dried.

Abstract translation: 目的：制备药物的制备方法，其通过将吸收期间不稳定并容易崩解的药物与粒径为10〜12μm的细颗粒结合使用，吸收改善了溶出度和口服吸收特性， 提供增强剂，其可以防止与其使用相关的不便和不良副作用，并增加药物的生物利用度，其通过口服给药时其活性丧失导致其使用价值降低。 构成：为了提高鲑鱼降钙素，蛋白质，肽材料和药物的生物降解能力，将药物溶解在甲醇，乙醇，丙酮，异丙醇等的混合溶液中，然后与吸收增强剂如胆汁酸，胆汁盐 ，转铁蛋白，叶酸等，以及可生物降解的聚合物。 此后，将混合溶液分散在40℃加热1小时的水溶液中，离心并干燥。