公开(公告)号：KR101315599B1

公开(公告)日：2013-10-10

申请号：KR1020110109270

申请日：2011-10-25

Applicant: 건국대학교 산학협력단

Inventor： 강영선 ,  최형좌 ,  박형순 ,  정우성

IPC: A61K47/48 ,  A61K47/42 ,  A61K39/002 ,  C08B37/00

Abstract: 본 발명은 폐렴균점막다당질 유형14 (CPS14)와 캐리어 단백질로서 식물성 전달단백질인 호스래디시 퍼옥시다제 (Horseradish Peroxidase)의 당단백중합체에 관한 것으로서, 상기 제조된 당단백중합체는 SIGN-R1 수용체와 결합하여 장시간 탐식세포들에게 탐식되지 않고 그 세포막에 고정되어 있음을 확인할 수 있었다. 이로써 CPS14C1은 CPS14에 대한 면역반응을 획득시킬 수 있는 효과를 나타내며, 따라서 이를 인체에 무해한 신물질로 개발할 수 있음을 확인하였다.

公开(公告)号：KR1020130047777A

公开(公告)日：2013-05-09

申请号：KR1020110109270

申请日：2011-10-25

Applicant: 건국대학교 산학협력단

Inventor： 강영선 ,  최형좌 ,  박형순 ,  정우성

IPC: A61K47/48 ,  A61K47/42 ,  A61K39/002 ,  C08B37/00

CPC classification number: A61K39/385 ,  A61K47/646 ,  A61K2039/6031

Abstract: PURPOSE: A glycoprotein conjugate of Pneumococcus capsular polysaccharide type 14(CSP 14) and horseradich peroxidase is provided to ensure immune response to CPS 14, and to develop a novel material which is harmless to human body. CONSTITUTION: A glycoprotein conjugate is prepared by conjugating Pneumococcus capsular polysaccharide type 14(CSP 14) and horseradich peroxidase. CPS 14 is oxidized. Horseradich peroxidase is modified by 2-succinimidyl-3-(2-pyridyldithio)propionate(SPDP) and ditiothreitol(DTT). A method for preparing the glycoprotein conjugate comprises: a step of oxidizing CPS14; and a step of reacting horseradich peroxidase with SPDP and DTT and preparing C1-SPDP-DTT. [Reference numerals] (AA) CPS13C1 is fixed on the surface of an SIGN-R1 or human DC-SIGN expression cell strain and is not reversed to the outside of a cell

Abstract translation: 目的：提供14型肺炎球菌荚膜多糖（CSP 14）和辣根过氧化物酶的糖蛋白结合物，以确保对CPS14的免疫应答，并开发出对人体无害的新型材料。 构成：通过结合Pneumococcus荚膜多糖14型（CSP14）和辣根过氧化物酶制备糖蛋白缀合物。 CPS14被氧化。 辣根过氧化物酶由2-琥珀酰亚胺基-3-（2-吡啶基二硫代）丙酸酯（SPDP）和二氨基苏糖醇（DTT）修饰。 制备糖蛋白缀合物的方法包括：氧化CPS14的步骤; 以及将辣根过氧化物酶与SPDP和DTT反应并制备C1-SPDP-DTT的步骤。 （标号）（AA）CPS13C1固定在SIGN-R1或人DC-SIGN表达细胞株的表面上，不与细胞外反向

公开(公告)号：KR101449599B1

公开(公告)日：2014-10-13

申请号：KR1020130066945

申请日：2013-06-12

Applicant: 다이아텍코리아 주식회사 ,  건국대학교 산학협력단

Inventor： 강영선 ,  고기남 ,  박계신 ,  박형순 ,  조미연 ,  김한나

IPC: C12N5/071 ,  A61K35/28 ,  A61K31/409 ,  A61K47/48 ,  A61K49/04

CPC classification number: C12N5/0692 ,  A61K31/409 ,  A61K35/28 ,  A61K47/50 ,  A61K49/04

Abstract: The present invention relates to an adult stem cell including a photosensitizer and an agent to treat cancer cells. The stem cell is produced by a method including a step of treating a mesenchymal stem cell with tromethamine. A method in the new concept of treating cancer using the adult stem as a carrier for the photosensitizer applies an agent transferring and the agent capable of targeting cancer cells, and has the advantages of treating both using the adult stem cell and photodynamic therapy.

Abstract translation: 本发明涉及包含光敏剂和治疗癌细胞的药剂的成体干细胞。 干细胞通过包括用氨丁三醇治疗间充质干细胞的步骤的方法产生。 使用成人干细胞作为光敏剂载体的治疗癌症的新概念中的方法应用能够靶向癌细胞的药剂转移剂和药剂，并且具有使用成体干细胞和光动力疗法治疗两者的优点。