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1.发明公开
公开(公告)号：KR1020120092382A
公开(公告)日：2012-08-21
申请号：KR1020110012399
申请日：2011-02-11
Applicant: 건국대학교 산학협력단
IPC: C12N5/0735 , C12N5/079 , C12N5/10 , C12N15/12
Abstract: PURPOSE: A method for promoting differentiation of embryonic stem cells into neuronal precursor cells is provided to enhance cell survival rate and differentiation efficiency. CONSTITUTION: A method for promoting differentiatioin of embryonic stem cells into neuronal precursor cells comprise a step of introducing Bax inhibitor-1 gene to embryonic stem cells and expressing the Bax inhibitor-1 in the embryonic stem cells. The Bax inhibitor-1 has an amino acid sequence of sequence number 1. The Bax inhibitor-1 gene has a base of sequence number 2. A composition for promoting differentiation of the embryonic stem cells into neuronal precursor cells contains the Bax inhibitor-1 as an active ingredient.
Abstract translation: 目的：提供一种促进胚胎干细胞分化为神经元前体细胞的方法，以增强细胞存活率和分化效率。 构成：促进胚胎干细胞分化为神经元前体细胞的方法包括将Bax抑制剂-1基因引入胚胎干细胞并在胚胎干细胞中表达Bax抑制剂-1的步骤。 Bax抑制剂-1具有序列号1的氨基酸序列.Bax抑制剂-1基因具有序列号2的碱基。用于促进胚胎干细胞分化为神经元前体细胞的组合物含有Bax抑制剂-1作为 活性成分。
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Patent Agency Ranking2.发明授权
公开(公告)号：KR101268561B1
公开(公告)日：2013-05-28
申请号：KR1020110012399
申请日：2011-02-11
Applicant: 건국대학교 산학협력단
IPC: C12N5/0735 , C12N5/079 , C12N5/10 , C12N15/12
Abstract: 본발명은백스저해제-1을도입한배아줄기세포로부터네스틴포지티브세포의분화촉진방법및 그조성물에관한것이다.
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公开(公告)号：KR101283398B1
公开(公告)日：2013-07-08
申请号：KR1020110012395
申请日：2011-02-11
Applicant: 건국대학교 산학협력단
Abstract: 본 발명은 췌장상피세포를 이용한 효율적인 역분화 만능유도세포 개발방법 및 그 조성물에 관한 것으로, 더욱 상세하게는 비만이 없는 당뇨병 (Nonobese diabetic, NOD) 생쥐 유래 췌장상피세포를 이용한 효율적인 역분화 만능유도세포 개발 및 그 조성물에 관한 것이다.
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公开(公告)号：KR1020120092379A
公开(公告)日：2012-08-21
申请号：KR1020110012395
申请日：2011-02-11
Applicant: 건국대학교 산학협력단
Abstract: PURPOSE: A method for developing iPSc using pancreatic epithelial cells and a composition for the same are provided to identify diabetes-related mechanism and to develop a therapeutic agent for treating diabetes. CONSTITUTION: A method for preparing iPSc(induced pluripotent stem cell) comprises a step of culturing pancreatic epithelial cells from an NOD(nonobese diabetic) mouse. A composition for preparing the iPSc contains the NOD mouse as an active ingredient. A method for establishing iPSc comprises: a step of producing virus particles containing oct4, sox2, klf4 or c-myc gene and a step of introducing the gene into the pancreatic epithelial cells.
Abstract translation: 目的：提供使用胰腺上皮细胞和其组合物开发iPSc的方法，以鉴定糖尿病相关机制并开发治疗糖尿病的治疗剂。 构成：制备iPSc（诱导性多能干细胞）的方法包括从NOD（非肥胖糖尿病）小鼠培养胰腺上皮细胞的步骤。 用于制备iPSc的组合物含有NOD小鼠作为活性成分。 一种建立iPSc的方法包括：产生含有oct4，sox2，klf4或c-myc基因的病毒颗粒的步骤和将该基因导入胰腺上皮细胞的步骤。
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公开(公告)号：KR1020120092378A
公开(公告)日：2012-08-21
申请号：KR1020110012391
申请日：2011-02-11
Applicant: 건국대학교 산학협력단
Abstract: PURPOSE: A method for developing induced pluripotent stem cells(iPSc) using nonobese diabetic(NOD) mouse-derived amnion epithelial cells is provided to identify diabetes mechanism and to develop a therapeutic agent for treating diabetes. CONSTITUTION: A method for preparing induced pluripotent stem cells(iPSc) comprise a step of culturing amnion epithelial cells derived from NOD(nonobese diabeteic) mouse amnion. A composition for preparing iPSc contains the amnion epithelial cells as an active ingredient. A vector for establishing iPSc contains oct4, sox2, klf4 or c-myc gene.
Abstract translation: 目的：提供使用非肥胖糖尿病（NOD）小鼠来源的羊膜上皮细胞诱导多能干细胞（iPSc）的方法，以鉴定糖尿病机制并开发治疗糖尿病的治疗剂。 构成：制备诱导多能干细胞（iPSc）的方法包括培养源自NOD（非肥胖糖尿病）小鼠羊膜的羊膜上皮细胞的步骤。 用于制备iPSc的组合物含有羊膜上皮细胞作为活性成分。 用于建立iPSc的载体含有oct4，sox2，klf4或c-myc基因。
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