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公开(公告)号：KR1020130094377A
公开(公告)日：2013-08-26
申请号：KR1020120014925
申请日：2012-02-14
Applicant: 경상대학교산학협력단
IPC: A01H5/00 , C07K14/415 , C12N15/29 , C12N15/82
CPC classification number: C12N15/8263 , C07K14/415 , C12N15/1137 , C12N15/8216
Abstract: PURPOSE: An arabidopsis apoptosis inhibitor - analog protein (AtILP) is provided to show anti-apopotosis activation in Arabidopsis in spite of the lack of baculovirus IAP repetition (BIR) domain. CONSTITUTION: An apoptosis inhibitor-analog protein relieving apoptosis comprises ring finger domain on the C-terminus, and is lack of baculovirus IAP repetition (BIR) domain. A transgenic plant having anti-apoptosis activation overexpresses the Arabidopsis apoptosis inhibitor-analog protein (AtILP).
Abstract translation: 目的：提供拟南芥凋亡抑制剂 - 类似蛋白（AtILP），以显示拟南芥中的抗凋亡活性，尽管缺乏杆状病毒IAP重复（BIR）域。 构成：凋亡抑制剂 - 类似蛋白缓解凋亡包括C末端的指环结构域，缺乏杆状病毒IAP重复（BIR）域。 具有抗凋亡活化的转基因植物过表达拟南芥凋亡抑制剂 - 类似蛋白（AtILP）。
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公开(公告)号：KR101285631B1
公开(公告)日：2013-07-12
申请号：KR1020110043312
申请日：2011-05-09
Applicant: 경상대학교산학협력단
Abstract: 본 발명은 AtPP5 변이 유전자 컨스트럭트를 지닌 열 완충성이 증진된 형질전환 아라비돕시스 식물체에 관한 것이다. 더욱 상세하게는 세린/트레오닌 단백질 포스파타아제 5(AtPP5) (AGI Code : At2G42810)의 변이체의 과발현을 통해 열 완충성이 증진되고 분자 샤페론 활성이 유지된 아라비돕시스
형질전환 식물체에 관한 것이다. 또한 상기 아라비돕시스
형질전환 식물체는 고온 충격시 아라비돕시스 탈리아나에서 분리된 세린/트레오닌 단백질 포스파타아제 5(AtPP5) 변이체가 모노머 또는 올리고머 형태의 저분자량 형태에서 고분자량 콤플렉스로 변환되며, 저분자량 형태인 경우 AtPP5는 폴다아제(foldase) 샤페론 및 탈인산화효소 활성을 나타내고 고분자량 콤플렉스 형태인 경우 AtPP5 콤플렉스는 홀다아제(holdase) 샤페론 활성을 나타내어 열 완충성이 증진된 아라비돕시스 형질전환 식물체에 관한 것이다.-
公开(公告)号：KR1020100124385A
公开(公告)日：2010-11-29
申请号：KR1020090043348
申请日：2009-05-19
Applicant: 경상대학교산학협력단
IPC: C07K14/415 , A01H1/00 , C12N15/29
Abstract: PURPOSE: A plant with enhanced resistance at high resistance through oligomerization of thioredoxin-like protein is provided to ensure enhanced thermal resistance. CONSTITUTION: An AtTDX protein(GenBank assession number: NP_188415) comprises 380 amino acids. The protein contains a tetratricopeptide repeat(TPR) domain at amino acid residue 112-213th site and Trx domain at amino acid residue 270-380th site. A plant having resistance at high temperature expressed AtTDX protein.
Abstract translation: 目的：提供通过硫氧还蛋白样蛋白的低聚，提高耐药性的植物，以确保增强耐热性。 构成：AtTDX蛋白（GenBank分配号：NP_188415）包含380个氨基酸。 蛋白质在氨基酸残基112-213位点含有四肽多肽重复序列（TPR）结构域，氨基酸残基270-380位点含有Trx结构域。 在高温下具有抗性的植物表达AtTDX蛋白。
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公开(公告)号：KR101308971B1
公开(公告)日：2013-09-16
申请号：KR1020110023765
申请日：2011-03-17
Applicant: 경상대학교산학협력단
IPC: C07K14/395 , A61K38/16 , A61P3/00
Abstract: 본 발명은 퍼옥시좀 목표 시그널 1(PTS1)-특이 분자 샤프론으로 작용하는 효모 Pex5p 단백질에 관한 것이다. 더욱 상세하게는 퍼옥시좀 목표 시그널 1(PTS1) 단백질의 유입 수용체 및 분자 샤프론으로 작용하는 다양한 분자량 형태를 지닌 효모 Pex5p 단백질에 관한 것이다. 또한 효모 Pex5p 단백질의 분자 샤프론 기능을 활용한 젤웨거 증후군, 신생상형 부신백질장애 및 영아형 레프숨병과 같은 대사 질환 치료용 의약 조성물을 제공하는 것이다.
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公开(公告)号：KR1020120105980A
公开(公告)日：2012-09-26
申请号：KR1020110023765
申请日：2011-03-17
Applicant: 경상대학교산학협력단
IPC: C07K14/395 , A61K38/16 , A61P3/00
Abstract: PURPOSE: A yeast Pex5p protein functioning as a peroxisome targeting signal 1-specific molecular chaperone is provided to treat metabolic diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy. CONSTITUTION: A yeast Pex5p protein has three WXXXF/Y motifs(W is trpytophane, F is phenylalanine, Y is tyrosine, and X is a random amino acid) and seven TPR domains. The molecular chaperone is activated through the three TPR domains. A pharmaceutical composition for treating metabolic diseases contains the yeast Pex5p proteins. The metabolic diseases are Zellweger syndrome, neonatal adrenaleukodystropy(NALD), and infantile refsum disease(IRD). [Reference numerals] (AA) GST : : yeastPex5p(1-612); (BB) GST : : yeastPex5p(120-612); (CC) GST : : yeastPex5p(204-612); (DD) GST : : yeastPex5p(267-612); (EE) GST : : yeastPex5p(267-524); (FF) GST : : yeastPex5p(267-490); (GG) GST : : yeastPex5p(267-456); (HH) GST : : yeastPex5p(267-412); (II) GST : : yeastPex5p(267-380); (JJ) GST : : yeastPex5p(267-346); (KK) GST : : yeastPex5p(267-311)
Abstract translation: 目的：提供作为过氧化物酶体靶向信号1特异性分子伴侣的酵母Pex5p蛋白，用于治疗代谢性疾病如泽尔韦格综合征和新生儿肾上腺脑白质营养不良。 构成：酵母Pex5p蛋白具有三个WXXXF / Y基序（W是trpytophane，F是苯丙氨酸，Y是酪氨酸，X是一个随机氨基酸）和七个TPR结构域。 分子伴侣通过三个TPR结构域被激活。 用于治疗代谢疾病的药物组合物含有酵母Pex5p蛋白。 代谢性疾病是泽尔韦格综合征，新生儿肾上腺ropy ropy（NALD）和婴儿痉挛症（IRD）。 （附图标记）（AA）GST：：酵母Pex5p（1-612）; （BB）GST：：yeastPex5p（120-612）; （CC）GST：：yeastPex5p（204-612）; （DD）GST：：yeastPex5p（267-612）; （EE）GST：：yeastPex5p（267-524）; （FF）GST：：yeastPex5p（267-490）; （GG）GST：：yeastPex5p（267-456）; （HH）GST：：yeastPex5p（267-412）; （II）GST：：yeastPex5p（267-380）; （JJ）GST：：yeastPex5p（267-346）; （KK）GST：：yeastPex5p（267-311）
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Patent Agency Ranking
公开(公告)号：KR101073849B1
公开(公告)日：2011-10-14
申请号：KR1020090043348
申请日：2009-05-19
Applicant: 경상대학교산학협력단
IPC: C07K14/415 , A01H1/00 , C12N15/29
Abstract: 본발명은티오레독신유사단백질의올리고머화를통한고온저항성이증진된식물체에관한것이다. 더욱상세하게는고온충격시티오레독신유사단백질의일종인 AtTDX 단백질(GenBank 수납번호: NP_188415)이올리고머화를통해저분자량형태의 AtTDX 단백질의폴다제샤페론및 이황화물환원효소기능을고분자량형태의 AtTDX 단백질기능인홀다제샤페론으로전환됨으로서고온저항성이증진된식물체에관한것이다.
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公开(公告)号：KR101432023B1
公开(公告)日：2014-08-22
申请号：KR1020120105571
申请日：2012-09-24
Applicant: 경상대학교산학협력단
Abstract: 본 발명은 산화 환원 의존적 설피닉산 환원효소인 아라비돕시스 설피레독신(AtSrx)(서열번호: 1)에 있어서, 상기 아라비돕시스 설피레독신은 산화 환원 비의존적으로 핵산 결합 및 분해 활성을 지니는 뉴클레아제로 작용하고, 서열번호: 1의 94번 아미노산 잔기인 시스테인이 설피닉산 환원효소 효소활성의 활성 부위임을 특징으로 하는 아라비돕시스 설피레독신에 관한 것이다. 또한 본 발명은 상기 아라비돕시스 설피레독신을 과발현하여 활성산소종(ROS)에 의해 손상된 유전정보를 지닌 핵산들을 제거시킴으로써 활성산소종 스트레스 저항성을 지닌 형질전환 식물체를 제공하는 것이다.
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公开(公告)号：KR1020140043531A
公开(公告)日：2014-04-10
申请号：KR1020120105571
申请日：2012-09-24
Applicant: 경상대학교산학협력단
CPC classification number: C12N15/8271 , C12N9/0051 , C12N15/8205 , C12N15/8237 , C12Y108/98002
Abstract: The present invention relates to arabidopsis sulfiredoxin (AtSrx) (sequence number: 1), which is an oxidation-reduction dependent sulfinic acid reducing enzyme, and more specifically, to arabidopsis sulfiredoxin that acts as a nuclease having oxidation-reduction independent nucleic acid-binding and decomposition activity, and has cysteine, an animo acid residue in sequence number 1-94, as an activation portion of the sulfinic acid reducing enzyme activity. Also, the present invention provides a transgenic plant which has stress resistance to reactive oxygen species (ROS) by removing nucleic acid with genetic information damaged by the reactive oxygen species through the overexpression of the arabidopsis sulfiredoxin.
Abstract translation: 本发明涉及作为氧化还原依赖性亚磺酸还原酶的阿拉伯糖硫磺酸毒素（AtSrx）（序列号：1），更具体地，涉及作为具有氧化还原独立核酸结合的核酸酶的拟南芥磺酰基毒素 和分解活性，并且具有半胱氨酸，序列号为1-94的animo酸残基作为亚磺酸还原酶活性的活化部分。 此外，本发明提供了一种转基因植物，其通过通过阿拉伯磷酸硫毒素过量表达除去具有由活性氧物质损伤的遗传信息的核酸而具有对活性氧（ROS）的胁迫性。
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公开(公告)号：KR1020130026057A
公开(公告)日：2013-03-13
申请号：KR1020110089412
申请日：2011-09-05
Applicant: 경상대학교산학협력단
IPC: C12N15/29 , C07K14/415
Abstract: PURPOSE: 1-cysteine peroxiredoxin protein which functions as a molecular chaperone in oxidative stress condition is provided to control seed germination and plant growth. CONSTITUTION: 1-cysteine peroxiredoxin protein is derived from Brassica rapa. The protein promotes seed germination and plant growth through a functional change by peroxidation of an active cysteine residue in oxidative stress condition. The protein has a preserved cysteine residue at 46th, 72th, and 131th amino acid residues. [Reference numerals] (AA) H_2O_2 reduction(umol/min/mmol Prx); (BB) Control group
Abstract translation: 目的：提供在氧化应激条件下作为分子伴侣的1-半胱氨酸过氧氧化还原蛋白，以控制种子萌发和植物生长。 构成：1-半胱氨酸过氧氧化还原蛋白源自芸苔属。 蛋白质通过活性半胱氨酸残基在氧化应激条件下的过氧化反应，通过功能改变促进种子发芽和植物生长。 该蛋白质在第46,77和131个氨基酸残基处具有保留的半胱氨酸残基。 （AA）H_2O_2还原（umol / min / mmol Prx）; （BB）对照组
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公开(公告)号：KR1020120125709A
公开(公告)日：2012-11-19
申请号：KR1020110043312
申请日：2011-05-09
Applicant: 경상대학교산학협력단
CPC classification number: C12N15/8271 , C12N9/16 , C12N15/8205 , C12Y301/03016
Abstract: PURPOSE: A transgenic Arabidopsis plant containing AtPP5 mutant gene construct is provided to enhance heat shock resistance and to enhance phosphatase activity. CONSTITUTION: A serine/threonine protein phosphatase 5(AtPP5) protein contains: three tetratricopeptide repeat(TPR) domain at amino acid residue 13-110 regions; a helix at amino acid 114-150 regions; a phosphatase active region at amino acid 190-459 regions; and a nuclear localization signal(NLS) region at amino acid 459-484 regions. The AtPP5 is denoted by sequence number 1. A method for producing a transgenic Arabidopsis plant which overexpresses AtPP5 protein or mutant thereof comprises: a step of assembling cDNA encoding serine/threonine protein phosphatase 5(AtPP5) or cDNA construct encoding a mutant of the protein; a step of inserting the cDNA into T-plasmid expression vector and co-culturing the vector with Argobacterium strain and Arabidopsis callus; a step of transducing the cDNA construct into Arabidopsis plant cells and transforming; and a step of growing the transformed plant cells. [Reference numerals] (AA, BB) Phosphatase
Abstract translation: 目的：提供含有AtPP5突变基因构建体的转基因拟南芥植物，以提高耐热休克性和增强磷酸酶活性。 构成：丝氨酸/苏氨酸蛋白磷酸酶5（AtPP5）蛋白含有：在氨基酸残基13-110个区域的三个四肽重复序列（TPR）结构域; 在氨基酸114-150个区域的螺旋; 在氨基酸190-459区域的磷酸酶活性区; 和位于氨基酸459-484区域的核定位信号（NLS）区。 AtPP5由序列号1表示。用于产生过表达AtPP5蛋白或其突变体的转基因拟南芥植物的方法包括：组装编码丝氨酸/苏氨酸蛋白磷酸酶5（AtPP5）的cDNA或编码蛋白质突变体的cDNA构建体的步骤 ; 将cDNA插入T质粒表达载体并用Argobacterium菌株和拟南芥愈伤组织共培养载体的步骤; 将cDNA构建体转导到拟南芥植物细胞中并转化的步骤; 以及生长转化的植物细胞的步骤。 （参考号）（AA，BB）磷酸酶
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