公开(公告)号：KR101629963B1

公开(公告)日：2016-06-14

申请号：KR1020080070468

申请日：2008-07-21

Applicant: 경희대학교 산학협력단

Inventor： 임성빈 ,  정경희 ,  엄윤경 ,  이진성 ,  정주호

IPC: C12Q1/68

Abstract: 본발명은염증성질환에서특이적인발현양상을보이는유전자를이용한 cDNA 마이크로어레이칩, 상기칩을이용하여염증질환을스크리닝하는방법, 및상기칩을이용한염증성질환치료제를스크리닝하는방법에관한것이다.

公开(公告)号：KR1020100009720A

公开(公告)日：2010-01-29

申请号：KR1020080070468

申请日：2008-07-21

Applicant: 경희대학교 산학협력단

Inventor： 임성빈 ,  정경희 ,  엄윤경 ,  이진성 ,  정주호

IPC: C12Q1/68

CPC classification number: C40B40/06 ,  C12Q1/6883 ,  C12Q2600/136

Abstract: PURPOSE: A cDNA(complementary DNA) microarray chip using a gene having expression in inflammatory diseases is provided to early diagnose inflammatory diseases and develop a therapeutic agent. CONSTITUTION: A cDNA microarray chip for diagnosing inflammatory diseases contains a nucleotide of a gene of which expression is specifically increased or decreased in inflammatory diseases. Screening for inflammatory diseases is performed using a cDNA microarray chip. A method for screening inflammatory diseases comprises a step of inducing inflammatory reaction by treating LPS to Raw 246.7 cell line and selecting factor. A therapeutic agent for treating inflammatory diseases is a regulator of gene expression by binding to antisense oligonucleotide, peptide, small molecular compound, antibody or target promoter.

Abstract translation: 目的：提供使用在炎性疾病中具有表达的基因的cDNA（互补DNA）微阵列芯片，以早期诊断炎性疾病并开发治疗剂。 构成：用于诊断炎性疾病的cDNA微阵列芯片含有炎症性疾病特异性增加或减少的基因的核苷酸。 使用cDNA微阵列芯片进行炎症性疾病的筛选。 一种筛选炎性疾病的方法包括通过将LPS处理至Raw 246.7细胞系和选择因子来诱导炎症反应的步骤。 用于治疗炎性疾病的治疗剂是通过结合反义寡核苷酸，肽，小分子化合物，抗体或靶启动子来调节基因表达。