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公开(公告)号：WO2013048124A9
公开(公告)日：2013-04-04
申请号：PCT/KR2012/007778
申请日：2012-09-26
Applicant: 경희대학교 산학협력단
IPC: A61C7/00
Abstract: 본 발명은 타이포돈트와 로드셀을 이용한 교정력 측정기에 관한 것으로, 보다 상세하게는 타이포돈트에 교정력 인가용 와이어를 연결하고 로드셀을 도입하여 교정력을 측정함으로써 영상 기반의 측정방식에서 발생할 수 있는 측정오차를 줄여 정밀한 교정력의 측정과 동시에 3차원적인 교정력 측정이 가능한 타이포돈트와 로드셀을 이용한 교정력 측정기를 제공한다.
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公开(公告)号：KR101304707B1
公开(公告)日：2013-09-06
申请号：KR1020110008900
申请日：2011-01-28
Applicant: 대한민국(농촌진흥청장) , 경희대학교 산학협력단
IPC: A61K36/258 , A61P25/28 , A61P25/00
Abstract: 본 발명은 인지 기능 개선 조성물에 관한 것이다. 본 발명의 인지 기능 개선 조성물은 인삼을 유효 성분으로 함유하는 것을 특징으로 하여 이루어진다.
본 발명의 인삼을 유효 성분으로 함유하는 인지 기능 개선 조성물은 인삼을 함유하는 것으로 인해 시각적 언어학습능력과 시각적 기억 회상 능력이 개선되어 전체적으로 인지 기능의 향상에 기여하는 효과가 있다.-
3.发明公开
公开(公告)号：KR1020100122403A
公开(公告)日：2010-11-22
申请号：KR1020090041425
申请日：2009-05-12
Applicant: 경희대학교 산학협력단
CPC classification number: C12Q1/6837 , C12N15/11 , C12Q1/6827 , C12Q2600/156 , G01N30/72 , G06F19/00
Abstract: PURPOSE: A method for determining administration of talniflumate by SNP analysis and a gene used for the same are provided to determine proper administration amount of talniflumate by analyzing the relation of pharmacodynamic parameter and SNP. CONSTITUTION: A method for determining Cmax(maximum plasma concentration) of talniflumate by SNP comprises: a step of collecting biological sample from an individual; a step of analyzing gene of biological sample using SNP chip and identifying genotype thereof; a step of determining Cmax in a value indicated in each line of M1 row in case that the genotype of SNP is indicated in G1 row of figure 1a-1j; and a step of determining Cmax in a value indicated in each line of figure 1a-1j in case that the genotype of SNP is indicated in each line of G3 row of figure 1a-1j.
Abstract translation: 目的：提供通过SNP分析确定脱硝酸盐的施用方法和用于本发明的基因的方法，通过分析药效学参数和SNP的关系来确定塔硝酸盐的适当给药量。 构成：通过SNP测定塔芬酸盐的Cmax（最大血浆浓度）的方法包括：从个体收集生物样品的步骤; 使用SNP芯片分析生物样品基因并鉴定其基因型的步骤; 在图1a-1j的G1行中指示SNP的基因型的情况下，确定M1行的每行中指示的值中的Cmax的步骤; 以及在图1a-1j的G3行的每一行中指示SNP的基因型的情况下，确定图1a-1j的各行所示值的Cmax的步骤。
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4.发明授权
公开(公告)号：KR101126023B1
公开(公告)日：2012-03-20
申请号：KR1020090041425
申请日：2009-05-12
Applicant: 경희대학교 산학협력단
Abstract: 본 발명은 단일 염기 다형성의 분석에 의한 탈니플루메이트의 맞춤형 투여량의 결정방법 및 그에 사용되는 유전자에 관한 것으로, 개체가 갖는 단일 염기 다형성의 분석에 의해 탈니플루메이트의 약동학적 파라미터에 영향을 미치는 유전적 요인들을 확인하고, 상기 단일 염기 다형성과 상기 약동학적 파라미터의 관계를 분석하여 탈니플루메이트의 투여 계획에 활용함으로써 개체의 유전적 차이에 따라 탈니플루메이트의 적절한 투여량을 결정하는 데 유용하게 사용될 수 있다.
단일 염기 다형성, 탈니플루메이트, 약동학적 파라미터-
公开(公告)号：KR1020120087605A
公开(公告)日：2012-08-07
申请号：KR1020110008900
申请日：2011-01-28
Applicant: 대한민국(농촌진흥청장) , 경희대학교 산학협력단
IPC: A61K36/258 , A61P25/28 , A61P25/00
CPC classification number: A61K36/258 , A23V2200/322
Abstract: PURPOSE: A composition containing ginseng for improving a cognitive function is provided to improve visual linguistics learning and visual memory recalling abilities. CONSTITUTION: A composition for improving a cognitive function contains ginseng as an active ingredient. The ginseng is white and red ginseng. The white ginseng is prepared removing peel of 4-year old raw ginsengs and drying. The red ginseng is prepared by steaming the raw ginseng. The cognitive function is a visual cognitive function.
Abstract translation: 目的：提供含有提高认知功能的人参的组合物，以改善视觉语言学习和视觉记忆能力。 构成：用于改善认知功能的组合物含有人参作为活性成分。 人参是白参和红参。 白参，准备去除4年生人参脱皮干燥。 红参是通过蒸制生的人参制成的。 认知功能是视觉认知功能。
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Patent Agency Ranking
公开(公告)号：KR101141343B1
公开(公告)日：2012-05-03
申请号：KR1020080070467
申请日：2008-07-21
Applicant: 경희대학교 산학협력단
Abstract: PURPOSE: A composition containing garlic extract for anti-aging is provided to highly suppressing aging in skin cells. CONSTITUTION: A composition for skin anti-aging contains garlic extract as an active ingredient. The garlic extract is isolated using water, low alcohol of C1-C4, or their mixture solvent. The extract is an extract, dilutant, concentrate, dried product, or purified product. The composition for skin anti-aging is a cosmetic composition or food composition. The cosmetic composition also contains carrier and adjuvant such as antioxidant, stabilizing agent, solubilizing agent, vitamin, pigment, and perfume. The food composition contains citric acid, liquid fructose, sugar, glucose, acetic acid, and fruit juice.
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公开(公告)号：KR1020100009719A
公开(公告)日：2010-01-29
申请号：KR1020080070467
申请日：2008-07-21
Applicant: 경희대학교 산학협력단
CPC classification number: A61K8/97 , A61K36/8962 , A61K2236/33 , A61Q19/08 , Y10S514/844
Abstract: PURPOSE: A composition containing garlic extract for anti-aging is provided to highly suppressing aging in skin cells. CONSTITUTION: A composition for skin anti-aging contains garlic extract as an active ingredient. The garlic extract is isolated using water, low alcohol of C1-C4, or their mixture solvent. The extract is an extract, dilutant, concentrate, dried product, or purified product. The composition for skin anti-aging is a cosmetic composition or food composition. The cosmetic composition also contains carrier and adjuvant such as antioxidant, stabilizing agent, solubilizing agent, vitamin, pigment, and perfume. The food composition contains citric acid, liquid fructose, sugar, glucose, acetic acid, and fruit juice.
Abstract translation: 目的：提供含有大蒜提取物抗老化的组合物，以高度抑制皮肤细胞的老化。 构成：用于皮肤抗衰老的组合物含有大蒜提取物作为活性成分。 使用水，C1-C4的低级醇或其混合溶剂分离大蒜提取物。 提取物是提取物，稀释剂，浓缩物，干燥产物或纯化产物。 用于皮肤抗衰老的组合物是化妆品组合物或食品组合物。 化妆品组合物还含有载体和助剂如抗氧化剂，稳定剂，增溶剂，维生素，颜料和香料。 食物组合物含有柠檬酸，液体果糖，糖，葡萄糖，乙酸和果汁。
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8.发明授权단일 염기 다형성의 분석에 의한 피오글리타존의 맞춤형 투여량의 결정방법 및 그에 사용되는 유전자 有权通过单核多核苷酸多态性分析测定PIOGLITAZONE的个体化剂量的方法及其使用的基因
公开(公告)号：KR101139171B1
公开(公告)日：2012-04-26
申请号：KR1020090088737
申请日：2009-09-18
Applicant: 경희대학교 산학협력단
Abstract: PURPOSE: A method for determining dosage of pioglitazone by SANP analysis by analyzing the relation of dynamic parameter and SNP. CONSTITUTION: A method for determining pioglitazone Cmax(maximum plasma concentration) by SNA comprises: a step of collecting a biological sample from an individual; a step of analyzing genes of the biological sample using SNP chip to identify SNP and genotype thereof; and a step of determining the value of indicated in M1 row of piroglitazone in case that genotypes of SNP are indicated in each row of G1.
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公开(公告)号：KR1020100009720A
公开(公告)日：2010-01-29
申请号：KR1020080070468
申请日：2008-07-21
Applicant: 경희대학교 산학협력단
IPC: C12Q1/68
CPC classification number: C40B40/06 , C12Q1/6883 , C12Q2600/136
Abstract: PURPOSE: A cDNA(complementary DNA) microarray chip using a gene having expression in inflammatory diseases is provided to early diagnose inflammatory diseases and develop a therapeutic agent. CONSTITUTION: A cDNA microarray chip for diagnosing inflammatory diseases contains a nucleotide of a gene of which expression is specifically increased or decreased in inflammatory diseases. Screening for inflammatory diseases is performed using a cDNA microarray chip. A method for screening inflammatory diseases comprises a step of inducing inflammatory reaction by treating LPS to Raw 246.7 cell line and selecting factor. A therapeutic agent for treating inflammatory diseases is a regulator of gene expression by binding to antisense oligonucleotide, peptide, small molecular compound, antibody or target promoter.
Abstract translation: 目的：提供使用在炎性疾病中具有表达的基因的cDNA（互补DNA）微阵列芯片，以早期诊断炎性疾病并开发治疗剂。 构成：用于诊断炎性疾病的cDNA微阵列芯片含有炎症性疾病特异性增加或减少的基因的核苷酸。 使用cDNA微阵列芯片进行炎症性疾病的筛选。 一种筛选炎性疾病的方法包括通过将LPS处理至Raw 246.7细胞系和选择因子来诱导炎症反应的步骤。 用于治疗炎性疾病的治疗剂是通过结合反义寡核苷酸，肽，小分子化合物，抗体或靶启动子来调节基因表达。
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公开(公告)号：KR1020070117373A
公开(公告)日：2007-12-12
申请号：KR1020060051571
申请日：2006-06-08
Applicant: 경희대학교 산학협력단
IPC: A61K36/752 , A61P35/00 , A61P29/00
CPC classification number: A61K36/752 , A61K2236/39 , Y10S514/886
Abstract: A therapeutic agent HJ001 isolated from Citrus reticulata Blanco is provided to inhibit growth of cancer cells and reduce expressions of IL-3(interleukin-3), IL-6, IL-12p40p70, IL-12p70 and SCF(stem cell factor) and increase expressions of IL-10 and TNF(tumor necrosis factor), so that it is useful for treatment of cancer and inflammatory disease. A method for preparing the extract of Citrus reticulata Blanco HJ001 comprises the steps of: dipping Citrus reticulata Blanco powder in water and filtering the solution; passing the filtered solution through the column packed with fillers HP-20 and collecting passed solution; mixing the collected solution with water-saturated ethylacetate to transfer it into an ethylacetate layer; inducing layer separation of the mixture into the ethylacetate layer and water layer, and separating the water layer; mixing the water layer with water-saturated butanol and separating a butanol layer; absorbing the butanol layer to TLC(thin layer chromatography) silica; subjecting the TLC silica by using chloroform, methanol and water as development solvent and separating the developed portion; dissolving the developed portion in butanol, and filtering and concentrating the solution; freeze-drying the filtered solution to obtain materials Fr1 and Fr2; and separating the Fr2 from the Fr1 and Fr2.
Abstract translation: 提供从柑橘网布兰科分离的治疗剂HJ001，以抑制癌细胞的生长并降低IL-3（白细胞介素-3），IL-6，IL-12p40p70，IL-12p70和SCF（干细胞因子）的表达并增加 IL-10和TNF（肿瘤坏死因子）的表达，因此可用于治疗癌症和炎性疾病。 柑橘柑橘提取物Blanco HJ001的制备方法，包括：将柑橘网Blanco粉浸入水中过滤溶液; 将过滤的溶液通过填充有填料HP-20的柱并收集通过的溶液; 将收集的溶液与水饱和的乙酸乙酯混合以将其转移到乙酸乙酯层中; 诱导层将混合物分离成乙酸乙酯层和水层，并分离水层; 将水层与水饱和的丁醇混合并分离丁醇层; 将丁醇层吸收至TLC（薄层色谱法）二氧化硅; 用氯仿，甲醇和水作为显影溶剂对TLC二氧化硅进行处理，分离显影部分; 将显影部分溶解在丁醇中，过滤并浓缩溶液; 冷冻干燥过滤溶液以获得材料Fr1和Fr2; 并将Fr2与Fr1和Fr2分离开。
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