公开(公告)号：KR1020100133237A

公开(公告)日：2010-12-21

申请号：KR1020090052025

申请日：2009-06-11

Applicant: 고려대학교 산학협력단

Inventor： 이광원 ,  홍충의 ,  이동호 ,  홍성수 ,  김종탁

IPC: A61K31/7048 ,  A61K36/9068 ,  A61P39/06 ,  A61P1/16

CPC classification number: A61K31/7048 ,  A61K36/54 ,  A61K2236/33 ,  A61K2236/55

Abstract: PURPOSE: A method for isolating quercetin-3-O-alpha-rhamnoside and campherol-3-O-alpha-rhamnoside from ginger is provided to ensure antioxidation and liver protection without side effects and toxicity. CONSTITUTION: A method for extracting and isolating quercetin-3-O-alpha-rhamnoside or campherol-3-O-alpha-rhamnoside comprises: a step of preparing crude extract from Lindera obtusiloba Blume using water or alcohol; a step of treating hexane to obtain aqueous layer; and a step of treating ethyl acetate to obtain ethyl acetate layer. The alcohol is methanol, ethanol, propanol, or butanol. An antioxidtion composition contains quercetin-3-O-alpha-rhamnoside or campherol-3-O-alpha-rhamnoside as an active ingredient.

Abstract translation: 目的：提供从姜中分离槲皮素-3-O-α-鼠李糖苷和campherol-3-O-α-鼠李糖苷的方法，以确保抗氧化和肝脏保护，无副作用和毒性。 构成：提取和分离槲皮素-3-O-α-鼠李糖苷或Campherol-3-O-α-鼠李糖苷的方法包括：使用水或醇制备来自白芷的粗提物的步骤; 处理己烷以获得水层的步骤; 以及处理乙酸乙酯以获得乙酸乙酯层的步骤。 醇是甲醇，乙醇，丙醇或丁醇。 抗氧化组合物含有槲皮素-3-O-α-鼠李糖苷或Campherol-3-O-α-鼠李糖苷作为活性成分。

公开(公告)号：KR100839185B1

公开(公告)日：2008-06-17

申请号：KR1020070034732

申请日：2007-04-09

Applicant: 고려대학교 산학협력단

Inventor： 이광원 ,  이현순 ,  홍충의 ,  정성훈 ,  김종탁

IPC: A61K31/7028 ,  A61K36/68 ,  A61P3/10

CPC classification number: A61K31/7028 ,  A23L33/105 ,  A61K31/05 ,  A61K31/235 ,  A61K36/68 ,  A61K2236/33 ,  B01D15/34 ,  Y10S514/866

Abstract: A composition comprising plantamajoside derived from a natural plant is provided to show increased efficacy than a conventional diabetes/diabetic complications inhibiting material without side effects and toxicity, thereby being widely used as a health functional food or a medicine for preventing and treating the diabetes/diabetic complications. A composition for preventing or treating diabetes and diabetic complications comprises plantamajoside derived from Plantago asiatica as an effective ingredient. A method for preparing the composition comprises the steps of: (a) powderizing an alcohol extract of the Plantago asiatica; (b) after dissolving the powder in water, extracting the solution in sequence using hexane, chloroform, ethyl acetate and butanol in accordance with a polarity; and (c) subjecting the organic solvent extract obtained from the step(b) to gel filtration chromatography. Further, the gel filtration chromatography is performed by using a silica gel 60 or Sepadex LH-20.

Abstract translation: 提供了包含来源于天然植物的植物苷的组合物，以显示比常规的糖尿病/糖尿病并发症抑制物质没有副作用和毒性增加的功效，从而被广泛用作健康功能食品或用于预防和治疗糖尿病/糖尿病的药物 并发症。 用于预防或治疗糖尿病和糖尿病并发症的组合物包括源自车前草的植物苷作为有效成分。 制备组合物的方法包括以下步骤：（a）粉化车前草的醇提取物; （b）将粉末溶解在水中后，依次使用己烷，氯仿，乙酸乙酯和丁醇依次萃取溶液; 和（c）使由步骤（b）获得的有机溶剂提取物进行凝胶过滤层析。 此外，通过使用硅胶60或Sepadex LH-20进行凝胶过滤层析。

公开(公告)号：KR101081601B1

公开(公告)日：2011-11-09

申请号：KR1020090052025

申请日：2009-06-11

Applicant: 고려대학교 산학협력단

Inventor： 이광원 ,  홍충의 ,  이동호 ,  홍성수 ,  김종탁

IPC: A61K31/7048 ,  A61K36/9068 ,  A61P39/06 ,  A61P1/16

Abstract: 본발명은생강나무로부터쿼세틴-3-O-알파-람노사이드및 캠페롤-3-O-알파-람노사이드의분리방법및 그것의항산화및 간보호용도에관한것이다.