公开(公告)号：KR100804032B1

公开(公告)日：2008-02-18

申请号：KR1020060111446

申请日：2006-11-13

Applicant: 고려대학교 산학협력단

Inventor： 이성준 ,  정미자 ,  박권우

IPC: A61K36/282 ,  A61P9/10

Abstract: A composition comprising a wormwood essential oil and vitamin E is provided to show the synergetic effect of the vitamin E on the antioxidation and cholesterol lowering functions of the wormwood essential oil, thereby being used as a raw material of raw materials of natural food and medicinal materials and health functional foods helpful for preventing and treating arteriosclerosis. A composition for lowering cholesterol comprises 0.1-0.4mg/ml of a wormwood essential oil belonging to Artemisia sp. and 0.01 ~ 0.2 mM of vitamin E as effective ingredients, where the wormwood essential oil is extracted by using a steam distillation method. The composition is characterized in that it has the antioxidative effect on oxidation of LDL in serum and increases the expression of an mRNA and a protein of an LDL receptor. A composition for preventing and treating arteriosclerosis comprises the composition as an effective ingredient.

Abstract translation: 提供包含蒿木精油和维生素E的组合物，以显示维生素E对蒿木精油的抗氧化和降胆固醇功能的协同作用，从而被用作天然食品和药用原料的原料 和健康功能食品有助于预防和治疗动脉硬化。 用于降低胆固醇的组合物含有0.1-0.4mg / ml的属于蒿属的蒿木精油。 和0.01〜0.2mM的维生素E作为有效成分，其中通过使用蒸汽蒸馏法提取蒿木精油。 该组合物的特征在于其对血清中LDL的氧化具有抗氧化作用，并增加LDL受体的mRNA和蛋白质的表达。 用于预防和治疗动脉硬化的组合物包含该组合物作为有效成分。

公开(公告)号：KR1020080100723A

公开(公告)日：2008-11-19

申请号：KR1020070046755

申请日：2007-05-14

Applicant: 고려대학교 산학협력단

Inventor： 이성준 ,  정미자 ,  김경헌 ,  박권우

IPC: A61K36/68 ,  A61P9/10

CPC classification number: A61K36/68 ,  A23V2200/326 ,  A23V2200/3262 ,  C11B9/00 ,  Y10S514/824

Abstract: A composition for lowering cholesterol containing Plantago asiatica essential oil is provided to perform oxygen-resistant using steam distillation, to lower cholesterol and to prevent or cure arteriosclerosis. A composition for lowering cholesterol contains Plantago asiatica essential oil as an effective component. The Plantago asiatica essential oil is extracted by using a steam distillation method, and includes a linalool as a main volatile refined oil material, fenchyl alcohol, bicyclogermacrene, menthen-2,3-diol and eugenol. The Plantago asiatica essential oil increases an expression of the LDL receptor from liver cells of the human, educes an expression of an HMG-CoA reductase and lowers a cholesterol of the blood of the human and the liver and an intestines, and a neutral lipid.

Abstract translation: 提供用于降低含有车前草积分精油的胆固醇的组合物，以使用蒸汽蒸馏进行耐氧，降低胆固醇并预防或治愈动脉硬化。 用于降低胆固醇的组合物含有车草属植物精油作为有效成分。 通过使用蒸汽蒸馏法提取车前草精油，并且包括作为主要挥发性精制油材料的芳樟醇，曙光醇，双环己烯，薄荷烯-2,3-二醇和丁子香酚。 车前草亚油精油增加人肝脏细胞中LDL受体的表达，促进HMG-CoA还原酶的表达，并降低人和肝脏，肠和肠和中性脂质的血液中的胆固醇。

公开(公告)号：KR1020100130674A

公开(公告)日：2010-12-14

申请号：KR1020090049309

申请日：2009-06-04

Applicant: 고려대학교 산학협력단

Inventor： 이성준 ,  정미자 ,  김경헌 ,  조성윤

IPC: A61K36/53 ,  A61P3/10 ,  A23L1/30

CPC classification number: A61K36/53 ,  A23V2200/328 ,  A61K2236/331 ,  Y10S514/866

Abstract: PURPOSE: A composition containing lemon balm essential oil for reducing blood glucose is provided to improve GCK(hepatic gludokinase) activity and to suppress G6Pase(glucose-6-phosphatase) and PEPCK(phosphoenolpyruvate carboxykinase) activity. CONSTITUTION: A composition for reducing blood glucose contains lemon balm essential oil as an active ingredient. The lemon balm essential oil is isolated by steam distillation. A pharmaceutical composition and health food for preventing and treating diabetes contain the composition for removing blood glucose as an active ingredient.

Abstract translation: 目的：提供含有降低血糖的柠檬香精油的组合物，以改善GCK（肝纤维蛋白酶）活性，抑制G6Pase（葡萄糖-6-磷酸酶）和PEPCK（磷酸烯醇丙酮酸羧激酶）活性。 构成：用于降低血糖的组合物含有柠檬香精油作为活性成分。 柠檬香精油通过蒸汽蒸馏分离。 用于预防和治疗糖尿病的药物组合物和保健食品含有除去作为有效成分的血糖的组合物。