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Patent Agency Ranking1.发明公开
公开(公告)号：KR1020090106430A
公开(公告)日：2009-10-09
申请号：KR1020080101903
申请日：2008-10-17
Applicant: 고려대학교 산학협력단
CPC classification number: C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C40B40/08
Abstract: PURPOSE: A marker for diagnosing lung cancer susceptibility using HER-2 gene is provided to predict and screen high risk group of lung cancer, diagnose and treat lung cancer. CONSTITUTION: A marker for diagnosing lung cancer susceptibility comprises one or more polynucleotide selected from a group comprising: a polynucleotide having 1316th base of polynucleotide sequence number 1 (-3444th from translation initiator element of HER-2 gene) which C is substituted with T and comprising 100-500 serial DNA fragments, a polynucleotide having 2771th base which G is substituted with T and comprising 100-500 serial DNA fragments; and a polynucleotide having 32301th base which C is substituted with G and comprising 100-500 serial DNA fragments and its complementary polynucleotide.
Abstract translation: 目的：提供使用HER-2基因诊断肺癌易感性的标志物，用于预测和筛选肺癌高危组，诊断和治疗肺癌。 构成：用于诊断肺癌易感性的标记物包含一种或多种选自以下的多核苷酸：包含多核苷酸序列号1316的碱基（HER-2基因的翻译起始元件为第3444位）的多核苷酸，C被T取代， 包含100-500个连续DNA片段，具有第2771个碱基的多核苷酸，其G被T取代并包含100-500个连续DNA片段; 和具有32位碱基的多核苷酸，其C被G取代并且包含100-500个连续DNA片段及其互补多核苷酸。
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2.发明公开ＩＧＦＢＰ―３ 유전자를 이용한 폐암 감수성 진단용 마커 및 이를 이용한 폐암 감수성 예측 및 판단 방법 有权使用IGFBP-3基因诊断肺癌易感性的制造商以及使用该方法预测和分析对肺癌易感性的方法
公开(公告)号：KR1020090106429A
公开(公告)日：2009-10-09
申请号：KR1020080096633
申请日：2008-10-01
Applicant: 고려대학교 산학협력단
CPC classification number: C12Q1/6886 , C12Q1/6837
Abstract: PURPOSE: A diagnosis marker for lung cancer susceptibility using IGFBP-3 gene is provided to predict and screen high risk group of lung cancer. CONSTITUTION: A diagnosis marker for lung cancer susceptibility comprises one or more polynucleotide. The polynucleotide has 349th base (-1590th from transcription initiator element of IGFBP-3, Insulin-like growth factor binding protein-3 gene) which C is substituted with A and contains 10-2159 sequential DNA fragments.
Abstract translation: 目的：提供使用IGFBP-3基因的肺癌易感性诊断标志物，用于预测和筛选高危肺癌组。 构成：肺癌易感性的诊断标志物包含一种或多种多核苷酸。 该多核苷酸具有349位碱基（IGFBP-3的转录起始元件，胰岛素样生长因子结合蛋白-3基因的第1590位），C被A取代并含有10-2159个连续的DNA片段。
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公开(公告)号：KR101054517B1
公开(公告)日：2011-08-05
申请号：KR1020080096633
申请日：2008-10-01
Applicant: 고려대학교 산학협력단
Abstract: 본 발명은 폐암 발생 위험도의 예측 및 선별을 가능하게 하는 폐암 감수성 진단용 마커에 관한 것으로, 보다 구체적으로 새로이 발견한 IGFBP-3 (Insulin-like growth factor binding protein-3) 유전자의 단일 염기 다형성(SNP)인 -1590 C>A 및 -202 A>C 와 이들의 일배체형(haplotype)을 이용한 폐암 감수성 진단용 마커, 진단키트 및 이를 이용한 폐암 감수성 예측 및 진단 방법에 관한 것이다.
본 발명에 의하면, 환자군이 폐암 발암 고위험군에 속하는지 여부의 예측 및 선별이 가능하여 폐암의 조기진단 및 치료 등에 유용하게 이용될 수 있다.
폐암, IGFBP-3 (Insulin-like growth factor binding protein-3), 단일 염기 다형성 (SNP;single nucleotide polymorphism), 일배체형 (haplotype)-
4.发明授权
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5.发明公开ＲＡＳＳＦ１Ａ 유전자를 이용한 폐암 감수성 진단용 마커 및 이를 이용한 폐암 감수성 예측 및 판단 방법 无效使用RASSF1A基因诊断肺癌易感性的方法和使用这些方法预测和分析肺癌可能性的方法
公开(公告)号：KR1020100030718A
公开(公告)日：2010-03-19
申请号：KR1020080089569
申请日：2008-09-11
Applicant: 고려대학교 산학협력단
CPC classification number: C12Q1/6886 , C12Q1/6827
Abstract: PURPOSE: A marker for diagnosing lung cancer susceptibility is provided to predict the rise of lung cancer occurrence using RASSF1A gene SNP. CONSTITUTION: A marker for diagnosing lung cancer susceptibility comprises: a polynucleotide having 10-1142 serial DNA fragment, in which 342th base, C is substituted with T; a polynucleotide having 10-1142 serial DNA fragment, in which 660th base, T is substituted with C; and a polynucleotide selected from complementary polynucleotides thereof.
Abstract translation: 目的：提供诊断肺癌易感性的标志物，以预测使用RASSF1A基因SNP的肺癌发生率的上升。 构成：用于诊断肺癌易感性的标记物包括：具有10-1142个连续DNA片段的多核苷酸，其中第342位碱基，C被T取代; 具有10-1142个连续DNA片段的多核苷酸，其中第660个碱基，T被C取代; 和选自其互补多核苷酸的多核苷酸。
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