公开(公告)号：KR101484748B1

公开(公告)日：2015-01-21

申请号：KR1020140036462

申请日：2014-03-28

Applicant: 고려대학교 산학협력단

Inventor： 김종승 ,  이재홍 ,  히얀시아 ,  양즈강 ,  강철훈 ,  박나영 ,  정효성

IPC: G01N33/52 ,  C07F5/02 ,  C12M1/34

Abstract: The present invention relates to dual structure sensor for measuring intracellular viscosity and to a method for diagnosing diseases using the same. A compound included in the sensor is represented by following chemical formula 1, and is able to quantify the viscosity of mitochondria in a cell by a fluorescent ratio scale and fluorescent lifetime image (FLIM), thereby being used in diagnosis of mitochondrial-related diseases. [Chemical formula 1]

Abstract translation: 本发明涉及用于测量细胞内粘度的双重结构传感器以及使用其的疾病诊断方法。 包含在传感器中的化合物由以下化学式1表示，并且能够通过荧光比例标度和荧光寿命图（FLIM）来定量细胞中线粒体的粘度，从而用于线粒体相关疾病的诊断。 [化学式1]