公开(公告)号：KR100878585B1

公开(公告)日：2009-01-15

申请号：KR1020060119620

申请日：2006-11-30

Applicant: 국립암센터

Inventor： 김수열 ,  김대석

IPC: A61K31/7028 ,  A61P35/00

CPC classification number: A61K31/35 ,  A61K31/7028 ,  A61K31/704 ,  A61K2300/00

Abstract: 본 발명은 글루코사민, 글루코사민 유도체 또는 이들의 염을 포함하는 항암감작제에 관한 것으로, 항암제를 투여하여 암을 치료하는 경우 항암제의 효과를 높여주는 글루코사민, 글루코사민의 유도체 또는 이들의 염을 포함하는 항암감작제에 관한 것이다. 본 발명은 또한 상기의 항암감작제를 투여하여 항암제내성을 극복하는 방법에 관한 것이다.
항암감작제, 글루코사민, 항암제 내성

公开(公告)号：KR1020070120015A

公开(公告)日：2007-12-21

申请号：KR1020060119620

申请日：2006-11-30

Applicant: 국립암센터

Inventor： 김수열 ,  김대석

IPC: A61K31/7028 ,  A61P35/00

CPC classification number: A61K31/35 ,  A61K31/7028 ,  A61K31/704 ,  A61K2300/00

Abstract: A cancer sensitizer is provided to make cancer cells highly sensitive to anticancer agents without side effects in contrast to conventional chemical sensitizers by comprising glucosamine which is a natural material, or glucosamine derivatives. A cancer sensitizer comprises glucosamine, a glucosamine derivative or a salt thereof, wherein the glucosamine derivative is represented by the formula(2). In the formula(2), R is an acyl group having 2 to 18 carbon atoms or a straight or branched alkyl group having 1 to 5 carbon atoms. A composition for inhibiting chemoresistance comprises glucosamine, a glucosamine derivative, or a salt thereof, and a pharmaceutically acceptable carrier. An anticancer composition comprises the composition for inhibiting chemoresistance and an anticancer agent selected from the group consisting of mechlorethamine, chlorambucil, phenylalanine, mustard, cyclophosphamide, ifosfamide, carmustine(BCNU), lomustine(CCNU), streptozotocin, busulfan, thiotepa, cisplatin, carboplatin, dactinomycin(actinomycin D), doxorubicin(adriamycin), daunorubicin, idarubicin, mitoxantrone, plicamycin, mitomycin, C bleomycin, vincristine, vinblastine, paclitaxel, docetaxel, etoposide, teniposide, topotecan and irinotecan. A method for overcoming chemoresistance comprises a step of administering the cancer sensitizer or the composition for inhibiting chemoresistance.

Abstract translation: 与常规化学敏化剂相反，通过包含作为天然材料的葡糖胺或葡糖胺衍生物，提供了癌症细胞以使癌细胞对抗癌剂高度敏感而没有副作用。 癌症敏化剂包括葡糖胺，葡糖胺衍生物或其盐，其中葡糖胺衍生物由式（2）表示。 式（2）中，R为碳原子数2〜18的酰基或碳原子数为1〜5的直链或支链烷基。 用于抑制化学抗性的组合物包括葡糖胺，葡糖胺衍生物或其盐和药学上可接受的载体。 抗癌组合物包含抑制化学抗性的组合物和选自以下的抗癌剂：氮芥，苯丁酸，苯丙氨酸，芥子，环磷酰胺，异环磷酰胺，卡莫司汀（BCNU），洛莫司汀（CCNU），链脲霉素，白消安，噻替派，顺铂，卡铂 ，多柔比星（放线菌素D），多柔比星（阿霉素），柔红霉素，伊达比星，米托蒽醌，普卡霉素，丝裂霉素，博莱霉素，长春新碱，长春花碱，紫杉醇，多西他赛，依托泊苷，替尼泊苷，托泊替康和伊立替康。 克服化学耐药性的方法包括施用癌症敏化剂或抑制化学抗性的组合物的步骤。