Abstract:
본 발명은 삼나물 ( Aruncus dioicus var. kamtschaticus ) 추출물, 또는 하기 화학식 1로 표시되는 아룬신 B (aruncin B) 또는 이의 약제학적으로 허용 가능한 염을 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물, 암세포의 에폽토시스 (apoptosis) 유도제 및 암의 예방 또는 개선용 건강 기능 식품에 관한 것이다. 본 발명에 따른 삼나물 추출물, 또는 화학식 1로 표시되는 아룬신 B 화합물 또는 이의 약제학적으로 허용 가능한 염은 급성 백혈병, 유방암, 대장암을 비롯한 각종 암의 예방, 개선 또는 치료에 효과를 나타내며, 이러한 물질들은 암세포에서 세포 자살을 유도하는 기전으로 작용하므로 이를 아폽토시스 유도제로서 유용하게 적용할 수 있는 우수한 효과를 가진다.
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating cancer which includes Aruncus dioicus var. kamtschaticus extract, aruncin B represented by chemical formula 1, or pharmaceutically acceptable salt thereof as an active ingredient, to an apoptosis inducing agent of cancer cells, and to health supplements for preventing or improving cancer. The Aruncus dioicus var. kamtschaticus extract, aruncin B represented by chemical formula 1, or pharmaceutically acceptable salt thereof has effects of preventing, improving or treating various kinds of cancers such as acute leukemia, breast cancer, and colorectal cancer. Such substances work by a mechanism which induces apoptosis of cancer cells so that the substances can be usefully applied as the apoptosis inducing agent.
Abstract:
PURPOSE: An Aruncus dioicus var. kamtschaticus extract, aruncin B, or a pharmaceutically acceptable salt thereof is provided to prevent, alleviate, or treat various cancers including acute leukemia, breast cancer, and colon cancer, and be used as an apoptosis inducer by a cancer cell apoptotic mechanism. CONSTITUTION: A pharmaceutical composition for preventing or treating cancer contains an Aruncus dioicus var. kamtschaticus extract as an active ingredient. The extract is prepared from the aerial part of Aruncus dioicus var. kamtschaticus using methylene chloride. An apoptosis inducer contains the extract as an active ingredient. A health functional food for preventing or treating cancer contains the extract as an active ingredient. The pharmaceutical composition also contains a compound of chemical formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient. The compound is isolated and purified from Aruncus dioicus var. kamtschaticus.
Abstract:
Provided are a transformed microorganism capable of expressing the surface antigen protein of Helicobacter pylori and an antigen protein extracted and purified from the microorganism so as to be usefully used for preventing and treating the Helicobacter pylori infection. The Cag12 protein of Helicobacter pylori K-51 comprises an amino acid sequence of SEQ ID : NO. 6. The isolated DNA comprises a sequence of SEQ ID : NO. 5 coding the protein. The vector includes a gene coding an outer membrane protein of Helicobacter pylori derived from human. The transformed microorganism is obtained by introducing the vector into E. coli pMG36e/cag12. To prepare an antigen protein of the Helicobacter pylori, the transformed E. coli is cultured. The vaccine for preventing the Helicobacter pylori infection comprises the antigen protein as an effective ingredient.
Abstract translation:提供能够表达幽门螺杆菌的表面抗原蛋白的转化微生物和从微生物中提取和纯化的抗原蛋白,以便有用地用于预防和治疗幽门螺杆菌感染。 幽门螺杆菌K-51的Cag12蛋白包含SEQ ID NO: 分离的DNA包含SEQ ID NO: 5编码蛋白质。 载体包括编码来自人的幽门螺杆菌的外膜蛋白的基因。 转化的微生物通过将载体导入大肠杆菌pMG36e / cag12而获得。 为了制备幽门螺杆菌的抗原蛋白,培养转化的大肠杆菌。 用于预防幽门螺杆菌感染的疫苗包含抗原蛋白作为有效成分。
Abstract:
본 발명은 삼나물 ( Aruncus dioicus var. kamtschaticus ) 추출물, 또는 하기 화학식 1로 표시되는 아룬신 B (aruncin B) 또는 이의 약제학적으로 허용 가능한 염을 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물, 암세포의 에폽토시스 (apoptosis) 유도제 및 암의 예방 또는 개선용 건강 기능 식품에 관한 것이다. 본 발명에 따른 삼나물 추출물, 또는 화학식 1로 표시되는 아룬신 B 화합물 또는 이의 약제학적으로 허용 가능한 염은 급성 백혈병, 유방암, 대장암을 비롯한 각종 암의 예방, 개선 또는 치료에 효과를 나타내며, 이러한 물질들은 암세포에서 세포 자살을 유도하는 기전으로 작용하므로 이를 아폽토시스 유도제로서 유용하게 적용할 수 있는 우수한 효과를 가진다.
Title translation:一种用于预防或治疗包含作为有效成分的US US ING ING ING ING ING OF OF OF OF OF OF OF A A A A A OD OD OD OD OD OD OD OD OD OD OD OD OD OD OD OD OD OD OD OD OD OD OD
Abstract:
A pharmaceutical composition for increasing immune effects comprising the extract of Polygonatum falcatum A. Gray is provided to increase production of antibodies against foreign antigens and improve a humoral immune response by promoting migration efficiency of leucocytes from peripheral blood into second immune organs. The pharmaceutical composition for increasing immune effects comprises the extract or purified fraction of Polygonatum falcatum A. Gray, wherein the extract of Polygonatum falcatum A. Gray is prepared by heating the root of Polygonatum falcatum A. Gray in water, and the purified fraction of Polygonatum falcatum A. Gray is prepared by adding acetone into the water extract of Polygonatum falcatum A. Gray to prepare 50% water and acetone mixed solvent and removing the precipitated matters from the solution so as to prepare the supernatant containing acetone-soluble components; adding acetone into the supernatant to prepare 80% water and acetone mixed solvent and recovering the precipitated matters; and dissolving the precipitated matters in distilled water and re-precipitating the solution with 80% acetone. A health food for increasing immune effects comprises the extract or purified fraction of Polygonatum falcatum A. Gray, wherein the health food is formulated as powder, granule, tablet, capsule or drink.
Abstract:
PURPOSE: A composition containing a compound isolated from Rubiae Radix is provided to reduce expression of protein which causes inflammation and pro-inflammatory cytokine expression. CONSTITUTION: A pharmaceutical composition for preventing and treating inflammatory disease contains a compound isolated from Rubiae Radix extract or pharmaceutically acceptable salt as an active ingredient. The compound is 2-carbomethoxy-2,3-epoxy-3-prenyl-1,4-naphthoquinone, 3'-bis(3,4-dihydro-4-hydroxy-6-methoxy-2H-1-benzopyran), Epoxymollugin, Soranjidiol, Oleanolic acid, 1-acetoxy-3-methoxy-9,10-anthraquinone, Alizarin 2-methyl ether, Furonollugin, or mollugin. The Rubiae Radix extract is crude extract, polar solvent soluble extract, or non-polar solvent soluble extract.
Abstract:
본 발명은 황정 추출물 또는 분획물을 포함하는 면역증강용 약학조성물에 관한 것으로, 본 발명의 황정 추출물 또는 분획물은 말초혈액내의 백혈구를 2차 면역기관으로의 이동효율을 증진시키는 작용을 하여 외래항원에 대한 항체생산력을 증가시키고 체액성 면역반응을 향상시켜 생성되는 항체의 역가를 높일 수 있으므로, 면역증강용 약학조성물 또는 건강기능식품으로 사용할 수 있다. 황정 추출물, 면역증강, 약학조성물, 건강기능식품