公开(公告)号：KR1020130057012A

公开(公告)日：2013-05-31

申请号：KR1020110122713

申请日：2011-11-23

Applicant: 대진대학교 산학협력단

Inventor： 김호 ,  남효정 ,  오아름 ,  석헌 ,  황재삼 ,  김성국

IPC: A61K38/17 ,  A61K38/08 ,  A61P9/10 ,  A61P19/02

CPC classification number: A61K38/1767 ,  C07K14/43563 ,  Y10S424/81 ,  Y10S514/824 ,  Y10S514/825

Abstract: PURPOSE: A composition for suppressing immunocytes containing a coprisin peptide derivative, CopA3(9-mer disulfide dimer), as an active ingredient is provided to significantly suppress activation of macrophage without side effects such as cytotoxicity, and to develop a novel therapeutic agent for treating immune diseases including arteriosclerosis and rheumatoid arthritis. CONSTITUTION: A composition for suppressing immunocytes contains a coprisin peptide derivative, CopA3(9-mer disulfide dimer), as an active ingredient. The derivative is a regulator which suppresses activation of immunocytes. The immunocytes are macrophage. The derivative is D-type and is derived from an insect. The derivative is used for treating immune diseases including arteriosclerosis and rheumatoid arthritis.

Abstract translation: 目的：提供用于抑制作为活性成分的CopA3（9-聚体二硫化物二聚体）的Copris3（9-聚体二硫化物二聚体）作为活性成分的抑制免疫细胞的组合物，以显着抑制巨噬细胞的活化而无副作用，例如细胞毒性，并开发新的治疗剂 免疫疾病，包括动脉硬化和类风湿性关节炎。 构成：用于抑制免疫细胞的组合物含有共感染肽衍生物CopA3（9-聚体二硫化物二聚体）作为活性成分。 该衍生物是抑制免疫细胞活化的调节剂。 免疫细胞是巨噬细胞。 衍生物是D型，衍生自昆虫。 该衍生物用于治疗包括动脉硬化和类风湿性关节炎在内的免疫疾病。