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公开(公告)号：KR1020130057012A
公开(公告)日：2013-05-31
申请号：KR1020110122713
申请日：2011-11-23
Applicant: 대진대학교 산학협력단
CPC classification number: A61K38/1767 , C07K14/43563 , Y10S424/81 , Y10S514/824 , Y10S514/825
Abstract: PURPOSE: A composition for suppressing immunocytes containing a coprisin peptide derivative, CopA3(9-mer disulfide dimer), as an active ingredient is provided to significantly suppress activation of macrophage without side effects such as cytotoxicity, and to develop a novel therapeutic agent for treating immune diseases including arteriosclerosis and rheumatoid arthritis. CONSTITUTION: A composition for suppressing immunocytes contains a coprisin peptide derivative, CopA3(9-mer disulfide dimer), as an active ingredient. The derivative is a regulator which suppresses activation of immunocytes. The immunocytes are macrophage. The derivative is D-type and is derived from an insect. The derivative is used for treating immune diseases including arteriosclerosis and rheumatoid arthritis.
Abstract translation: 目的：提供用于抑制作为活性成分的CopA3（9-聚体二硫化物二聚体）的Copris3（9-聚体二硫化物二聚体）作为活性成分的抑制免疫细胞的组合物，以显着抑制巨噬细胞的活化而无副作用，例如细胞毒性，并开发新的治疗剂 免疫疾病，包括动脉硬化和类风湿性关节炎。 构成：用于抑制免疫细胞的组合物含有共感染肽衍生物CopA3（9-聚体二硫化物二聚体）作为活性成分。 该衍生物是抑制免疫细胞活化的调节剂。 免疫细胞是巨噬细胞。 衍生物是D型，衍生自昆虫。 该衍生物用于治疗包括动脉硬化和类风湿性关节炎在内的免疫疾病。
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公开(公告)号：KR101336023B1
公开(公告)日：2013-12-03
申请号：KR1020110122714
申请日：2011-11-23
Applicant: 대진대학교 산학협력단
IPC: C12N5/0793 , C12N1/38 , C07K7/06
Abstract: 본 발명은 신경세포 성장 조절용 조성물에 관한 것이다. 이는 하기 아미노산 배열을 가지는 코프리신 펩티드 유도체 CopA3(9-mer disulfide dimer)를 유효 성분으로 함유할 수 있다.
본 발명의 조성물에 따르면, 예컨대 알츠하이머 증후군 또는 파킨슨 증후군과 같은 퇴행성 신경질환의 치료제로서 비용이 저렴하면서도 부작용이 없는 새로운 치료제의 제공이 가능하다는 등의 현저한 효과가 있다.-
公开(公告)号：KR1020130057013A
公开(公告)日：2013-05-31
申请号：KR1020110122714
申请日：2011-11-23
Applicant: 대진대학교 산학협력단
IPC: C12N5/0793 , C12N1/38 , C07K7/06
CPC classification number: C12N5/0619 , C07K7/06 , C12N1/38 , C12N2500/30
Abstract: PURPOSE: A composition for regulating growth of nerve cells containing coprisin peptide derivative, CopA3(9-mer disulfide dimer), as an active ingredient is provided to be used as a therapeutic agent for treating neurodegenerative diseases such as Alzheimer's diseases or Parkinson's disease without side effects. CONSTITUTION: A composition for regulating growth of nerve cells contains a coprisin peptide derivative, CopA3(9-mer disulfide dimer), with an amino acid sequence. The derivative is a regulator which promotes growth of nerve cells or suppresses programmed cell death of nerve cells. The nerve cells are brain cells. The derivative is D-type and is derived from an insect. The derivative is used for treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, or Huntington's disease.
Abstract translation: 目的：提供用于调节神经细胞生长的组合物，该组合物作为活性成分用作治疗神经变性疾病如阿尔茨海默病或帕金森氏病的治疗剂，CopA3（9-聚体二硫化物二聚体） 效果。 构成：用于调节神经细胞生长的组合物含有具有氨基酸序列的共立克斯肽衍生物CopA3（9-聚体二硫化物二聚体）。 该衍生物是促进神经细胞生长或抑制神经细胞程序性细胞死亡的调节剂。 神经细胞是脑细胞。 衍生物是D型，衍生自昆虫。 该衍生物用于治疗神经变性疾病如阿尔茨海默氏病，帕金森病或亨廷顿舞蹈病。
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