公开(公告)号：KR101029491B1

公开(公告)日：2011-04-18

申请号：KR1020090101244

申请日：2009-10-23

Applicant: 대진대학교 산학협력단

Inventor： 김호 ,  장창현 ,  남효정 ,  강진구

IPC: C12Q3/00 ,  C12Q1/02 ,  C12N5/02 ,  A61P31/00

CPC classification number: C12Q3/00 ,  C07K14/33 ,  C12Y305/01098

Abstract: PURPOSE: A method for suppressing cytotoxic action of clostridium difficile toxin is provided to suppress deacetylation and to cytotoxic mechanism. CONSTITUTION: A method for suppressing interaction of clostridium difficile toxin in a cell is performed by controlling tubulin-deacetylation of cells. The cells are epithelial cells of large intestine. The suppression method is used for treating Pseudomembranous colitis, Crohn's disease, and Ulcerative colitis.

Abstract translation: 目的：提供一种抑制艰难梭菌毒素的细胞毒作用的方法，以抑制脱乙酰化和细胞毒作用机制。 构成：通过控制细胞的微管蛋白脱乙酰化来进行抑制细菌中艰难梭菌毒素相互作用的方法。 细胞是大肠上皮细胞。 抑制方法用于治疗假膜性结肠炎，克罗恩病和溃疡性结肠炎。