公开(公告)号：KR101021226B1

公开(公告)日：2011-03-11

申请号：KR1020100037204

申请日：2010-04-22

Applicant: 대한민국(농촌진흥청장) ,  대진대학교 산학협력단

Inventor： 황재삼 ,  윤은영 ,  김성렬 ,  남성희 ,  안미영 ,  최영철 ,  김호 ,  남효정 ,  강진구 ,  김인우

IPC: A61K38/08 ,  A61P1/04 ,  A61P1/00

CPC classification number: A61K38/08

Abstract: PURPOSE: A composition containing coprisin peptide derivative CopA3(HL) for treating Pseudomembranous colitis is provided to prevent antibiotics effect to helpful microbes such as Bifidobacterium and Lactobacillus. CONSTITUTION: A composition for treating Pseudomembranous colitis contains coprisin peptide derivative CopA3(HL) as an active ingredient. The coprisin peptide derivative CopA3(HL) has an amino acid sequence(L-L-C-I-A-L-R-K-K). The coprisin peptide derivative suppresses Clostrdium difficile in the large intestine. The coprisin peptide derivative CopA3(HL) is D-type.

Abstract translation: 目的：提供含有用于治疗假膜性结肠炎的复合蛋白肽衍生物CopA3（HL）的组合物，以防止抗生素对有益微生物如双歧杆菌和乳杆菌的作用。 构成：用于治疗假膜性结肠炎的组合物含有作为活性成分的共感染肽衍生物CopA3（HL）。 共聚蛋白肽衍生物CopA3（HL）具有氨基酸序列（L-L-C-I-A-L-R-K-K）。 共感染肽衍生物抑制大肠中的艰难梭菌（Clostrdium difficile）。 共聚蛋白肽衍生物CopA3（HL）是D型。

公开(公告)号：KR101336023B1

公开(公告)日：2013-12-03

申请号：KR1020110122714

申请日：2011-11-23

Applicant: 대진대학교 산학협력단

Inventor： 김호 ,  남효정 ,  강진구 ,  석헌 ,  황재삼

IPC: C12N5/0793 ,  C12N1/38 ,  C07K7/06

Abstract: 본 발명은 신경세포 성장 조절용 조성물에 관한 것이다. 이는 하기 아미노산 배열을 가지는 코프리신 펩티드 유도체 CopA3(9-mer disulfide dimer)를 유효 성분으로 함유할 수 있다.

본 발명의 조성물에 따르면, 예컨대 알츠하이머 증후군 또는 파킨슨 증후군과 같은 퇴행성 신경질환의 치료제로서 비용이 저렴하면서도 부작용이 없는 새로운 치료제의 제공이 가능하다는 등의 현저한 효과가 있다.

公开(公告)号：KR1020130057013A

公开(公告)日：2013-05-31

申请号：KR1020110122714

申请日：2011-11-23

Applicant: 대진대학교 산학협력단

Inventor： 김호 ,  남효정 ,  강진구 ,  석헌 ,  황재삼

IPC: C12N5/0793 ,  C12N1/38 ,  C07K7/06

CPC classification number: C12N5/0619 ,  C07K7/06 ,  C12N1/38 ,  C12N2500/30

Abstract: PURPOSE: A composition for regulating growth of nerve cells containing coprisin peptide derivative, CopA3(9-mer disulfide dimer), as an active ingredient is provided to be used as a therapeutic agent for treating neurodegenerative diseases such as Alzheimer's diseases or Parkinson's disease without side effects. CONSTITUTION: A composition for regulating growth of nerve cells contains a coprisin peptide derivative, CopA3(9-mer disulfide dimer), with an amino acid sequence. The derivative is a regulator which promotes growth of nerve cells or suppresses programmed cell death of nerve cells. The nerve cells are brain cells. The derivative is D-type and is derived from an insect. The derivative is used for treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, or Huntington's disease.

Abstract translation: 目的：提供用于调节神经细胞生长的组合物，该组合物作为活性成分用作治疗神经变性疾病如阿尔茨海默病或帕金森氏病的治疗剂，CopA3（9-聚体二硫化物二聚体） 效果。 构成：用于调节神经细胞生长的组合物含有具有氨基酸序列的共立克斯肽衍生物CopA3（9-聚体二硫化物二聚体）。 该衍生物是促进神经细胞生长或抑制神经细胞程序性细胞死亡的调节剂。 神经细胞是脑细胞。 衍生物是D型，衍生自昆虫。 该衍生物用于治疗神经变性疾病如阿尔茨海默氏病，帕金森病或亨廷顿舞蹈病。

公开(公告)号：KR101029491B1

公开(公告)日：2011-04-18

申请号：KR1020090101244

申请日：2009-10-23

Applicant: 대진대학교 산학협력단

Inventor： 김호 ,  장창현 ,  남효정 ,  강진구

IPC: C12Q3/00 ,  C12Q1/02 ,  C12N5/02 ,  A61P31/00

CPC classification number: C12Q3/00 ,  C07K14/33 ,  C12Y305/01098

Abstract: PURPOSE: A method for suppressing cytotoxic action of clostridium difficile toxin is provided to suppress deacetylation and to cytotoxic mechanism. CONSTITUTION: A method for suppressing interaction of clostridium difficile toxin in a cell is performed by controlling tubulin-deacetylation of cells. The cells are epithelial cells of large intestine. The suppression method is used for treating Pseudomembranous colitis, Crohn's disease, and Ulcerative colitis.

Abstract translation: 目的：提供一种抑制艰难梭菌毒素的细胞毒作用的方法，以抑制脱乙酰化和细胞毒作用机制。 构成：通过控制细胞的微管蛋白脱乙酰化来进行抑制细菌中艰难梭菌毒素相互作用的方法。 细胞是大肠上皮细胞。 抑制方法用于治疗假膜性结肠炎，克罗恩病和溃疡性结肠炎。