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公开(公告)号：KR101293664B1
公开(公告)日：2013-08-07
申请号：KR1020100117104
申请日：2010-11-23
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: C07D303/12 , G01N33/92 , C07C57/24
Abstract: 말단 에폭시기를 갖는 지질 이중층이 표면에 고정된 고체 입자 및 그를 제조하는 방법를 제공한다. 또한, 말단 에폭시기를 통하여 상기 고체 입자에 프로브 분자가 고정화된 입자 및 그를 제조하는 방법을 제공한다.
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公开(公告)号：KR1020130078057A
公开(公告)日：2013-07-10
申请号：KR1020110146777
申请日：2011-12-30
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
Abstract: PURPOSE: A liposome containing phospholipid and an acetylene group is provided to manufacture a sensor with enhanced sensitivity and to sensitively detect a target material in a sample. CONSTITUTION: A liposome containing an acetylene group comprises lipid bilayer containing first and second lipid molecules. The first lipid molecule is a diacetylene molecule with an epoxy group at the end. The second lipid molecule is diacyl glycerol-3-phosphate molecule. The diacetylene molecule has a structure of formula I. The diacyl glycerol-3-phosphate molecule is 1,2-dimyristoyl-sn-glycero-3-phosphate (DMPA). A method for detecting a target material in a sample comprises the steps of: contacting a target material-binding material with the target material in the sample; detecting an optical signal; and identifying the target material from the optical signal.
Abstract translation: 目的：提供含有磷脂和乙炔基团的脂质体，以制造灵敏度更高的传感器，并灵敏地检测样品中的目标物质。 构成：含有乙炔基的脂质体包含含有第一和第二脂质分子的脂质双层。 第一种脂质分子是最后具有环氧基团的乙炔分子。 第二种脂质分子是二酰基甘油-3-磷酸分子。 二乙炔分子具有式I的结构。二酰基甘油-3-磷酸酯分子是1,2-二肉豆蔻酰-sn-甘油基-3-磷酸酯（DMPA）。 用于检测样品中的目标材料的方法包括以下步骤：使目标材料结合材料与样品中的目标材料接触; 检测光信号; 以及从光信号识别目标材料。
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公开(公告)号：KR1020120055385A
公开(公告)日：2012-05-31
申请号：KR1020100117104
申请日：2010-11-23
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: C07D303/12 , G01N33/92 , C07C57/24
Abstract: PURPOSE: A solid particle having end epoxy radical on lipid bilayer and a manufacturing method thereof are provided to uniformly fix molecules having amino radicals under mild condition. CONSTITUTION: A solid particle having end epoxy radical includes lipid bilayer coated with polyelectrolyte material on a surface. The lipid bilayer comprises a first lipid molecule and a second lipid molecule. The first lipid molecule is diacetylene having the first lipid molecule having epoxy radical in the end. The second lipid molecule is a different lipid molecule from the first lipid molecule. A solid particle before being coated with the polyelectrolyte material is negative charged material. A cationic polyelectrolyte material and electronegative polyelectrolyte material are coated by turns.
Abstract translation: 目的：提供在脂质双层上具有末端环氧基的固体颗粒及其制备方法，以均匀地固定温和条件下具有氨基的分子。 构成：具有末端环氧基的固体颗粒包括在表面上用聚电解质材料涂覆的脂质双层。 脂质双层包含第一脂质分子和第二脂质分子。 第一脂质分子是具有最终具有环氧基的第一脂质分子的乙炔。 第二脂质分子是与第一脂质分子不同的脂质分子。 在用聚电解质材料涂覆之前的固体颗粒是负带电材料。 阳离子聚电解质材料和电负极聚电解质材料被轮转涂覆。
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