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公开(公告)号：KR101636966B1
公开(公告)日：2016-07-11
申请号：KR1020140024179
申请日：2014-02-28
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: C12N5/0797 , C12N5/0735
Abstract: 본발명은배아줄기세포로부터신경교전구세포, 성상세포및 희소돌기아교세포로의분화방법에관한것이다. 본발명에따른배아줄기세포로부터신경교전구세포, 성상세포및 희소돌기아교세포로의분화방법을이용할경우, 수득된신경교전구세포의지속적인배양이가능하며, 상기신경교전구세포는성상세포및 희소돌기아교세포로의분화가가능하여이와관련된독성물질의스크리닝및 독성평가에유용하게이용될수 있다.
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公开(公告)号：KR1020150042344A
公开(公告)日：2015-04-21
申请号：KR1020130120602
申请日：2013-10-10
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: C12N5/074 , C12N5/0775 , C12N5/10 , C12N15/867
CPC classification number: C12N5/0696 , C12N5/0018 , C12N5/0606 , C12N15/867
Abstract: 본발명은 CD105세포에역분화인자가도입된유도만능줄기세포및 이의제조방법에관한것이다. 본발명에따른유도만능줄기세포는 CD105세포에역분화인자가도입됨으로써, CD105세포에역분화인자가도입된경우보다역분화형성효율및 집락발달이우수하고, 줄기세포의마커유전자를발현하며, 내배엽, 중배엽및 외배엽으로분화가가능하여, 세포치료제로유용하게사용할수 있다.
Abstract translation: 本发明涉及具有引入的重编程因子的诱导多能干细胞的CD105-CELL及其制造方法，其中允许诱导的多能干细胞将重编程因子引入CD105细胞，因此具有突出的重编程效率 与将重编程因子引入CD105 +细胞相比较，并表达干细胞的标记基因，从而分化内胚层，中胚层和外胚层，并用作细胞处理剂。
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Patent Agency Ranking
公开(公告)号：KR101650704B1
公开(公告)日：2016-08-30
申请号：KR1020130120602
申请日：2013-10-10
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: C12N5/074 , C12N5/0775 , C12N5/10 , C12N15/867
Abstract: 본발명은 CD105세포에역분화인자가도입된유도만능줄기세포및 이의제조방법에관한것이다. 본발명에따른유도만능줄기세포는 CD105세포에역분화인자가도입됨으로써, CD105세포에역분화인자가도입된경우보다역분화형성효율및 집락발달이우수하고, 줄기세포의마커유전자를발현하며, 내배엽, 중배엽및 외배엽으로분화가가능하여, 세포치료제로유용하게사용할수 있다.
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公开(公告)号：KR1020150051122A
公开(公告)日：2015-05-11
申请号：KR1020140024179
申请日：2014-02-28
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: C12N5/0797 , C12N5/0735
CPC classification number: C12N5/0618
Abstract: 본발명은배아줄기세포로부터신경교전구세포, 성상세포및 희소돌기아교세포로의분화방법에관한것이다. 본발명에따른배아줄기세포로부터신경교전구세포, 성상세포및 희소돌기아교세포로의분화방법을이용할경우, 수득된신경교전구세포의지속적인배양이가능하며, 상기신경교전구세포는성상세포및 희소돌기아교세포로의분화가가능하여이와관련된독성물질의스크리닝및 독성평가에유용하게이용될수 있다.
Abstract translation: 本发明涉及诱导胚胎干细胞将其分化成胶质祖细胞，星形胶质细胞和少突胶质细胞的方法。 根据本发明的一个实施方案，该方法包括以下步骤：1）培养胚胎干细胞以形成胚状体; 2）将胚状体分离成单个细胞并培养分离的单细胞以诱导神经干细胞的产生; 3）另外培养神经干细胞，将培养的神经干细胞分离成单细胞，将分离的神经干细胞传代培养5〜40次。 当使用根据本发明的方法时，可以连续培养获得的胶质祖细胞并诱导胶质祖细胞分化为星形胶质细胞和少突胶质细胞，从而有效地用于筛选与细胞有关的毒性物质并评估毒性 。
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公开(公告)号：KR1020140082021A
公开(公告)日：2014-07-02
申请号：KR1020120150936
申请日：2012-12-21
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: C12N5/0735 , C12N5/02
CPC classification number: C12N5/0696
Abstract: The present invention relates to a complete induced pluripotent stem cell obtained by treating sodium butyrate and a treating method thereof which contain a process of treating the sodium butyrate onto the complete induced pluripotent stem cell. According to the present invention, the production method can be effectively used for research of the relevant fields, as a partial induced pluripotent stem cell having an interval characteristic of a somatic cell and a stem cell can be efficiently converted into the complete induced pluripotent stem cell.
Abstract translation: 本发明涉及通过处理丁酸钠而获得的完全诱导的多能干细胞及其治疗方法，其包含将丁酸钠处理到完全诱导的多能干细胞上的方法。 根据本发明，生产方法可以有效地用于相关领域的研究，因为具有体细胞间隔特征的部分诱导多能干细胞和干细胞可以有效地转化为完全诱导的多能干细胞 。
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公开(公告)号：KR1020140082016A
公开(公告)日：2014-07-02
申请号：KR1020120150885
申请日：2012-12-21
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
CPC classification number: C12N15/11 , C12Q1/6844 , C12Q1/6886 , C12Q2600/154
Abstract: The present invention relates to a marker composition for diagnosis of bone marrow cancer and a kit and a method for diagnosis of bone marrow cancer including the marker. The marker composition of the present invention amplifies a certain area where CpG area of the gene BCL11a, RB1, GLIS2 and ABI2 is included, in order to compare similarities and differences of the methylation level of the gene. Hence, the present invention can effectively be used to promptly and accurately diagnose bone marrow cancer including T-cell lymphoma, B-cell lymphoma and leukemia.
Abstract translation: 本发明涉及用于诊断骨髓癌的标记组合物和用于诊断包括该标记物的骨髓癌的试剂盒和方法。 为了比较基因的甲基化水平的相似度和差异，本发明的标记物组合物扩增了包含基因BCL11a，RB1，GLIS2和ABI2的CpG面积的某一区域。 因此，本发明可以有效地用于及时，准确地诊断包括T细胞淋巴瘤，B细胞淋巴瘤和白血病在内的骨髓癌。
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公开(公告)号：KR101540719B1
公开(公告)日：2015-08-04
申请号：KR1020120150885
申请日：2012-12-21
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
Abstract: 본발명은골수암진단용마커조성물, 상기마커를포함하는골수암진단키트및 진단방법에관한것이다. 본발명에따른마커조성물은 BCL11a, RB1, GLIS2 및 ABI2 유전자의 CpG 부위가포함된특정부위를증폭하여, 상기유전자의메틸화정도를비교분석할수 있어, T세포림프종, B세포림프종및 백혈병을포함하는골수암을빠르고정확하게진단하는데유용하게이용될수 있다.
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