-
公开(公告)号：KR101149872B1
公开(公告)日：2012-06-27
申请号：KR1020090028760
申请日：2009-04-03
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K39/112 , C12N5/07 , A61K39/10 , A61P37/00
Abstract: 본 발명은 병원균의 약독화 방법에 관한 것으로, 보다 자세하게는 병원균과 호중구를 공동 배양함으로써 상기 병원균을 약독화시키는 방법, 이렇게 약독화된 병원균 변이주 및 상기 변이주를 함유하는 백신 조성물에 관한 것이다.
병원균, 살모넬라, 호중구, 약독화-
公开(公告)号：KR1020100110434A
公开(公告)日：2010-10-13
申请号：KR1020090028760
申请日：2009-04-03
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K39/112 , C12N5/07 , A61K39/10 , A61P37/00
CPC classification number: A61K39/0275 , A61K2039/522
Abstract: PURPOSE: A method for attenuating pathogen by co-culture of pathogen and neutrophil is provided to attenuate without high technology and safely apply to human body. CONSTITUTION: A pathogen is attenuated by co-culture of pathogen and neutrophils. The neutrophil is isolated from poultry, pig, lamb, horse, cat, dog or human. A method for co-culture of pathogen and neutrophil comprises: a step of co-culture of neutrophili and pathogen for 10 minutes to two hours; a step of killing pathogen; and a step of collecting and dissolving neutrophil. The attenuated pathogen is ST31-N5th-1(KACC 91447P) or ST31-N20th-B10th-12(KACC 91448P). A vaccine composition contains attenuated pathogenic mutant.
Abstract translation: 目的：通过病原体和嗜中性粒细胞的共培养来减轻病原体的方法，无需高技术的减毒，安全应用于人体。 构成：通过病原体和嗜中性粒细胞的共培养来减轻病原体。 嗜中性粒细胞与家禽，猪，羊，马，猫，狗或人类分离。 病原体和嗜中性粒细胞的共培养方法包括：将嗜中性粒细胞和病原体共培养10分钟至2小时的步骤; 杀死病原体的一个步骤; 和收集和溶解嗜中性粒细胞的步骤。 减毒病原体是ST31-N5th-1（KACC91447P）或ST31-N20th-B10th-12（KACC91448P）。 疫苗组合物含有减毒致病突变体。
-
Search Results
2
records
(took 0.02 seconds)
