公开(公告)号：KR100891881B1

公开(公告)日：2009-04-07

申请号：KR1020070084916

申请日：2007-08-23

Applicant: 대한민국(농촌진흥청장)

Inventor： 조강진 ,  강순아 ,  김만배 ,  이선주 ,  김정봉 ,  김철호 ,  서석종

IPC: A61K31/11 ,  A61K31/05 ,  A61P3/06

Abstract: 본 발명은 3,4,5-트리히드록시벤즈알데히드를 유효성분으로 포함하는 고지혈증 및 MMP 과다활성으로 인한 혈관질환 예방 및 치료용 조성물에 관한 것으로서 보다 상세하게는 국내 자생 식물인 뱀무에서 분리한 3,4,5-트리히드록시벤즈알데히드를 유효성분으로 포함하는 고지혈증 및 MMP 과다활성으로 인한 혈관질환 예방 및 치료용 조성물에 관한 것이다. 본 발명의 조성물은 세포 독성이 없으면서도 혈중 고밀도 콜레스테롤의 증가와 중성지방의 양을 감소시키며, 동맥평활근 세포의 MMP 활성을 저해함으로써 지질대사의 이상으로 발생되는 고지혈증 및 동맥경화증과 같은 MMP 과다활성으로 인한 혈관질환의 예방 및 치료하는 효과를 갖는다. 따라서, 본 발명의 조성물은 고지혈증 및 동맥경화와 같은 혈관질환의 예방 및 치료의 목적으로 사용할 수 있다.
뱀무, 고지혈증, 동맥경화, MMP, 예방, 치료

公开(公告)号：KR1020090020279A

公开(公告)日：2009-02-26

申请号：KR1020070084916

申请日：2007-08-23

Applicant: 대한민국(농촌진흥청장)

Inventor： 조강진 ,  강순아 ,  김만배 ,  이선주 ,  김정봉 ,  김철호 ,  서석종

IPC: A61K31/11 ,  A61K31/05 ,  A61P3/06

Abstract: A composition comprising 3,4,5-trihydroxybenzaldehyde is provided to increase blood high density cholesterol, reduce the amount of neutral fat, and inhibit MMP(matrix metalloproteinase) activity of arterial vascular smooth muscle cell, thereby preventing and treating hyperlipidemia and vascular disease such as arteriosclerosis. The pharmaceutical composition for preventing and treating hyperlipidemia and vascular disease due to highly activated MMP comprises 3,4,5-trihydroxybenzaldehyde separated from Geum japonicum THUNBERG or pharmaceutically acceptable salts thereof, wherein the vascular disease due to highly activated MMP is selected from arteriosclerosis, angina, myocardial infarction, hypertension, anemia, migraine, stroke and hemandioma.

Abstract translation: 提供包含3,4,5-三羟基苯甲醛的组合物以增加血液中的高密度胆固醇，减少中性脂肪的量，并抑制动脉血管平滑肌细胞的MMP（基质金属蛋白酶）活性，从而预防和治疗高脂血症和血管疾病 作为动脉硬化。 用于预防和治疗由高度活化的MMP引起的高脂血症和血管疾病的药物组合物包括从天麻日本THUNBERG分离的3,4,5-三羟基苯甲醛或其药学上可接受的盐，其中由高度活化的MMP引起的血管疾病选自动脉硬化，心绞痛 ，心肌梗塞，高血压，贫血，偏头痛，中风和血管瘤。

公开(公告)号：KR100718602B1

公开(公告)日：2007-06-21

申请号：KR1020050133322

申请日：2005-12-29

Applicant: 대한민국(농촌진흥청장)

Inventor： 조강진 ,  강순아 ,  김만배 ,  이선주 ,  김정봉 ,  임융호

IPC: A61K36/73 ,  A61P3/04

Abstract: An extract of Geum japonicum having anti-obesity and anti-inflammation effects, a food composition comprising the same extract and a preparation method of the same extract are provided to inhibit obesity by suppressing accumulation of neutral fat and GPDH(glycerol-3-phosphate dehydrogenase) activity, and inhibit inflammation by suppressing production of NO(nitrogen oxide) as an inflammation factor, and initial inflammatory cytokines of PGE2(Prostaglandin E), IL(interleukin)-1beta and TNF(tumor necrosis factor)-alpha. The method for preparing the extract of Geum japonicum having anti-obesity and anti-inflammation effects comprises the steps of: (1) extracting dried powder of Geum japonicum with methanol or ethanol, filtering the extract, and concentrating the filtered solution to obtain the methanol or ethanol extract; (2) adding hexane and water into the methanol or ethanol extract, separating a hexane layer and a water layer(i) and concentrating the hexane layer to obtain the hexane extract; (3) adding methylene chloride and water into the water layer(i), separating a methylene chloride layer and a water layer(ii) and concentrating the methylene chloride layer to obtain the methylene chloride extract; (4) adding ethyl acetate and water into the water layer(ii), separating an ethyl acetate layer and a water layer(iii) and concentrating the ethyl acetate layer to obtain the ethyl acetate extract; and (5) evaporating the water from the water layer(iii) to obtain the water layer.

Abstract translation: 提供一种具有抗肥胖和抗炎作用的金盏花提取物，包含该提取物的食品组合物以及该提取物的制备方法，以通过抑制中性脂肪和GPDH（甘油-3-磷酸脱氢酶 ）活性，并通过抑制作为炎症因子的NO（氮氧化物）的产生和PGE2（前列腺素E），IL（白细胞介素）-1β和TNF（肿瘤坏死因子）-α的最初炎性细胞因子来抑制炎症。 制备具有抗肥胖和抗炎作用的锦extract提取物的方法包括以下步骤：（1）用甲醇或乙醇提取锦鲤干燥粉末，过滤提取物，浓缩滤液得到甲醇 或乙醇提取物; （2）向甲醇或乙醇提取物中加入己烷和水，分离己烷层和水层（i），浓缩己烷层得到己烷提取物; （3）向水层（i）中加入二氯甲烷和水，分离二氯甲烷层和水层（ii），浓缩二氯甲烷层得到二氯甲烷提取物; （4）将乙酸乙酯和水加入水层（ii）中，分离乙酸乙酯层和水层（iii），浓缩乙酸乙酯层得到乙酸乙酯提取物; 和（5）从水层（iii）蒸发水以获得水层。