公开(公告)号：KR100873222B1

公开(公告)日：2008-12-10

申请号：KR1020060044286

申请日：2006-05-17

Applicant: 대한민국(농촌진흥청장)

Inventor： 김금숙 ,  성낙술 ,  박충범 ,  이승은 ,  장인복 ,  정태숙 ,  정해영

IPC: A61K36/22 ,  A61P35/00 ,  A61P9/10

Abstract: 본 발명은 붉나무로부터 분리한 담마레인 트리테르펜 (dammarane triterpene) 화합물을 함유하는 항산화, 항치매, 동맥경화 억제 및 항암 효과를 가지는 조성물에 관한 것이다. 붉나무 줄기를 추출하여 분리한 담마레인 트리테르펜 (dammarane triterpene) 화합물인 20-하이드록시-24-담마렌-3-온 (20-hydroxy-24-dammaren-3-one), 3-옥소담마르-20,24
E -다이엔-26-오익 엑시드 (3-oxodammar-20,24
E -dien-26-oic acid), 3-하이드록시-3,19-에폭시담마르-20,24-다이엔-22,26-올라이드 (3-hydroxy-3,19-epoxydammar-20,24-dien-22,26-olide)은 활성산소 저해활성, ACAT 저해활성, 항암 활성을 가지고 있다. 따라서 상기 화합물은 동맥경화증, 치매, 암 및 산화적 스트레스성 질환의 예방, 개선 및 치료에 유용하게 사용될 수 있다.
붉나무, 담마레인 트리테르펜, 동맥경화, 치매, 항산화, 항암, 산화적 스트레스, 건강기능성 식의약품

公开(公告)号：KR1020070111202A

公开(公告)日：2007-11-21

申请号：KR1020060044286

申请日：2006-05-17

Applicant: 대한민국(농촌진흥청장)

Inventor： 김금숙 ,  성낙술 ,  박충범 ,  이승은 ,  장인복 ,  정태숙 ,  정해영

IPC: A61K36/22 ,  A61P35/00 ,  A61P9/10

Abstract: A composition comprising dammarane triterpenes is provided to inhibit activity of ACAT(acyl-CoA:cholesterol acyltransferase), remove reactive oxygen species, peroxynitrite and hydrogen peroxide, suppress production of nitrogen oxide and kill cancer cells without side effects, thereby preventing or treating atherosclerosis, dementia, cancer and oxidative stress. A composition for preventing or treating atherosclerosis, dementia, cancer and oxidative stress comprises dammarane triterpenes isolated from Rhus chinensis Mill., including 20-hydroxy-24-dammaren-3-one represented by the formula(1), 3-hydroxy-3, 3-oxodammar-20, 24E-dien-26-oic acid represented by the formula(2) and 19-epoxydammar-20, 24-dien-22, 26-olide represented by the formula(3), which are isolated by extracting the stem of Rhus chinensis Mill. with methanol, fractionating the crude extract with ethylacetate and water, concentrating the fraction under reduced pressure, and subjecting the concentrate to silica gel column chromatography.

Abstract translation: 提供了含有马马龙三萜烯的组合物以抑制ACAT（酰基辅酶A：胆固醇酰基转移酶）的活性，去除活性氧，过氧亚硝酸盐和过氧化氢的活性，抑制氮氧化物的产生并杀死癌细胞而没有副作用，由此预防或治疗动脉粥样硬化， 痴呆，癌症和氧化应激。 用于预防或治疗动脉粥样硬化，痴呆，癌症和氧化应激的组合物包括从Rhus chinensis Mill分离的dammarane三萜烯，包括由式（1）表示的20-羟基-24-巴马仑-3-酮，3-羟基-3， 由式（2）表示的3-氧代醛-20,24E-二烯-26-酸和由式（3）表示的19-环氧基-20,20-二烯-22,26-二醇，其通过提取分离 枸杞子的茎。 用甲醇，用乙酸乙酯和水分离粗提物，减压浓缩，浓缩物经硅胶柱层析。

公开(公告)号：KR100852737B1

公开(公告)日：2008-08-20

申请号：KR1020070047221

申请日：2007-05-15

Applicant: 대한민국(농촌진흥청장)

Inventor： 이승은 ,  성낙술 ,  방진기 ,  김금숙 ,  박충범 ,  차선우 ,  정해영 ,  장인복

IPC: A61K36/18 ,  A61P1/16

Abstract: An extract of Lythrum salicaria roots and a fraction thereof are provided to show excellent antioxidizing activity and hepatic fibrosis inhibitory effect, thereby being applied as a medicine and a health functional food having antioxidant and liver protecting activities. A pharmaceutical composition for preventing or treating liver cirrhosis comprises 0.001-99.999 wt.% of an extract of Lythrum salicaria roots as an effective ingredient, wherein the extract is obtained by using a solvent such as water, methanol, ethanol, and a mixture thereof. Further, the extract comprises a fraction and a weight ratio of the extract and the fraction is 99.999:0.001 to 50:50.

Abstract translation: 提供枸杞子提取物及其一部分，以显示优异的抗氧化活性和肝纤维化抑制作用，从而作为具有抗氧化和肝保护活性的药物和保健功能食品。 用于预防或治疗肝硬化的药物组合物包含0.001-99.999重量％的枸杞根提取物作为有效成分，其中所述提取物通过使用溶剂如水，甲醇，乙醇及其混合物获得。 此外，提取物包含提取物和馏分的分数和重量比为99.999：0.001〜50:50。