公开(公告)号：KR1020100046905A

公开(公告)日：2010-05-07

申请号：KR1020080105945

申请日：2008-10-28

Applicant: 덕성여자대학교 산학협력단

Inventor： 이재인 ,  윤정숙

IPC: C07D215/08 ,  C07D215/06

Abstract: PURPOSE: A method for preparing 2-aryl-4-quinolone derivative is provided to suppress undesirable reaction during acetylation of N-phenylbenzamide. CONSTITUTION: A method for preparing 2-aryl-4-quinolone derivative comprises: a step of condensing benzaldehyde derivative with 2-aminoacetophenone derivative to obtain 1-(2'-aminophenyl)-3-phenyl-2-propene-1-one derivative; a step of cyclizing 1-(2'-aminophenyl)-3-phenyl-2-propene-1-one derivative to obtain 2,3-dihydro-2-aryl-4-quinolone derivative; and a step of performing dehydrogenation of 2,3-dihydro-2-aryl-4-quinolone derivative.

Abstract translation: 目的：提供2-芳基-4-喹诺酮衍生物的制备方法，以抑制乙酰化N-苯基苯甲酰胺期间的不良反应。 构成：2-芳基-4-喹诺酮衍生物的制备方法包括：将苯甲醛衍生物与2-氨基苯乙酮衍生物缩合得到1-（2'-氨基苯基）-3-苯基-2-丙烯-1-酮衍生物 ; 使1-（2'-氨基苯基）-3-苯基-2-丙烯-1-酮衍生物环化，得到2,3-二氢-2-芳基-4-喹诺酮衍生物的步骤; 以及进行2,3-二氢-2-芳基-4-喹诺酮衍生物的脱氢的工序。