公开(公告)号：KR1020140110161A

公开(公告)日：2014-09-17

申请号：KR1020130022980

申请日：2013-03-04

Applicant: 덕성여자대학교 산학협력단

Inventor： 이재인

IPC: C07D495/04 ,  A61K31/382 ,  A61P33/06 ,  A61P1/04

Abstract: A method for preparing heterocyclic derivatives of thioflavones according to the present invention is characterized by comprising a step of preparing heterocyclic derivatives of thioflavones of material 5 from material 1 below, as shown in reaction formula 1 below: (in reaction formula 1, X is any one selected from the group consisting of 2-thienyl. 3-Br(a), 3-thienyl. 2-Br(b), 3-pyridyl. 2-Cl(c), and 3-quinolyl. 2-Cl(d); and R is any one selected from the group consisting of C_6H_6(e), 3-Cl-C_6H_4(f), 4-CH_3-C_6H_4(g), 4-CH_3O-C_6H_4(h), 3,5-(CH_3O)_2-C_6H_3(i), 3-thienyl(j), and 3-pyridyl(f)).

Abstract translation: 根据本发明的制备噻吩酮的杂环衍生物的方法的特征在于包括如下反应式1所示的从下述材料1制备材料5的噻吩酮的杂环衍生物的步骤：（在反应式1中，X是任何 选自2-噻吩基，3-Br（a），3-噻吩基-2-Br（b），3-吡啶基2-Cl（c）和3-喹啉基的2选自2-Cl ），R是选自C 6 H 6（e），3-C 1 -C 6 H 4（f），4-CH 3 -C 6 H 4（g），4 -CH 3 O- C 6 H 4（h），3,5- CH 3 O）_2-C_6H_3（i），3-噻吩基（j）和3-吡啶基（f））。

公开(公告)号：KR1020100046905A

公开(公告)日：2010-05-07

申请号：KR1020080105945

申请日：2008-10-28

Applicant: 덕성여자대학교 산학협력단

Inventor： 이재인 ,  윤정숙

IPC: C07D215/08 ,  C07D215/06

Abstract: PURPOSE: A method for preparing 2-aryl-4-quinolone derivative is provided to suppress undesirable reaction during acetylation of N-phenylbenzamide. CONSTITUTION: A method for preparing 2-aryl-4-quinolone derivative comprises: a step of condensing benzaldehyde derivative with 2-aminoacetophenone derivative to obtain 1-(2'-aminophenyl)-3-phenyl-2-propene-1-one derivative; a step of cyclizing 1-(2'-aminophenyl)-3-phenyl-2-propene-1-one derivative to obtain 2,3-dihydro-2-aryl-4-quinolone derivative; and a step of performing dehydrogenation of 2,3-dihydro-2-aryl-4-quinolone derivative.

Abstract translation: 目的：提供2-芳基-4-喹诺酮衍生物的制备方法，以抑制乙酰化N-苯基苯甲酰胺期间的不良反应。 构成：2-芳基-4-喹诺酮衍生物的制备方法包括：将苯甲醛衍生物与2-氨基苯乙酮衍生物缩合得到1-（2'-氨基苯基）-3-苯基-2-丙烯-1-酮衍生物 ; 使1-（2'-氨基苯基）-3-苯基-2-丙烯-1-酮衍生物环化，得到2,3-二氢-2-芳基-4-喹诺酮衍生物的步骤; 以及进行2,3-二氢-2-芳基-4-喹诺酮衍生物的脱氢的工序。

公开(公告)号：KR101766414B1

公开(公告)日：2017-08-08

申请号：KR1020160042864

申请日：2016-04-07

Applicant: 덕성여자대학교 산학협력단

Inventor： 이재인

IPC: C07D471/04 ,  A61K31/4375

CPC classification number: C07D471/04 ,  A61K31/4375

Abstract: 본발명은 2-클로로니코틴산으로부터 1-알킬-2-페닐-1,8-나프티리딘-4-온을제조하는신규한제조방법을제공한다. 본발명의제조방법은출발물질로서 2-클로로니코틴산을이용하여간단한반응조건및 간단한단계를통해 1-알킬-2-페닐-1,8-나프티리딘-4-온및 약간의반응조건변경으로 1-알킬-2-페닐-2,3-디하이드로-1,8-나프티리딘-4-온을고수율로새롭게합성할수 있는장점이있다.

Abstract translation: 本发明提供了用于制备一种新颖的方法1-烷基-2-苯基-1,8-二氮杂萘-4-酮由2-氯 - 烟酸。 改变本发明的制造方法是2-氯 - 烟酸通过使用作为起始材料1的简单的反应条件和1-烷基-2-苯基-1,8-二氮杂萘-4-酮和一些反应条件简单的步骤 - 和烷基-2-苯基-2,3-二氢-1,8-二氮杂萘-4-酮存在能够以高收率新合成的优点。

公开(公告)号：KR101491239B1

公开(公告)日：2015-02-12

申请号：KR1020130022980

申请日：2013-03-04

Applicant: 덕성여자대학교 산학협력단

Inventor： 이재인

IPC: C07D495/04 ,  A61K31/382 ,  A61P33/06 ,  A61P1/04

Abstract: 본 발명에 따른 싸이오플라본의 헤테로고리 유도체의 제조 방법은 하기 반응식 1과 같이, 하기 물질 1로부터 물질 5의 싸이오플라본의 헤테로고리 유도체를 제조하는 단계를 포함하는 것을 특징으로 한다.


(상기 반응식 1에서 X는 2-thienyl. 3-Br(a), 3-thienyl. 2-Br(b), 3-pyridyl. 2-Cl(c), 및 3-quinolyl. 2-Cl(d)를 포함하는 군 중 어느 하나로 선택되고, 상기 R은 C
6 H
6 (e), 3-Cl-C
6 H
4 (f), 4-CH
3 -C
6 H
4 (g), 4-CH
3 OC
6 H
4 (h), 3,5-(CH
3 O)
2 -C
6 H
3 (i), 3-thienyl(j), 및 3-pyridyl(f)을 포함하는 군 중 어느 하나로 선택된다)

公开(公告)号：KR101342820B1

公开(公告)日：2013-12-17

申请号：KR1020130022979

申请日：2013-03-04

Applicant: 덕성여자대학교 산학협력단

Inventor： 김건희 ,  최은정 ,  이재인

IPC: C07D335/04 ,  A61K31/382 ,  A61P35/00 ,  A61P39/06

Abstract: 본발명은, 유방암세포주에대해암세포성장을억제하는성능을보이고, 탁월한항산화효과를나타내면, 활성산소에기인하는노화및 질환을억제하고치료하는데효과적인티오플라바논을유효성분으로함유하는화합물에관한것이다. 본발명의화합물은, 하기화학식 1로표시되는항암및 항산화활성을갖는화합물이다. [화학식 1]상기 R, R, R, R, R, R, 및 R은같거나다를수 있고, 수소, 할로, 알킬, 알콕시, NO, 및하이드록시로구성된군으로부터독립적으로선택된다.

公开(公告)号：KR1020100018909A

公开(公告)日：2010-02-18

申请号：KR1020080077645

申请日：2008-08-07

Applicant: 덕성여자대학교 산학협력단

Inventor： 이재인

IPC: C07D335/04

Abstract: PURPOSE: A method for preparing 2-phenylthiochroman-4-one derivative is provided to improvie yield of final product and without separation of chalcone compound. CONSTITUTION: A method for preparing thioflavanone(2-phenyl thiochroman-4-one) derivative comprises: a step of reacting methylation reagent with thiosalicylic acid to obtain 2'-mercaptoacetophenone; and a step of reacting benzealdehyde derivative to the 2'-mercaptoacetophenone to obtain 2-phenylthiochroman-4-one derivative. The methylation reagent is methyl lithium.

Abstract translation: 目的：提供2-苯基二氢苯并噻喃-4-酮衍生物的制备方法，以改善最终产物的产率，而不分离查耳酮化合物。 构成：制备噻吩酮（2-苯基二氢苯并噻喃-4-酮）衍生物的方法包括：使甲基化试剂与硫代水杨酸反应得到2'-巯基苯乙酮的步骤; 以及使苯甲醛衍生物与2'-巯基乙酰苯反应得到2-苯基二氢苯并噻喃-4-酮衍生物的工序。 甲基化试剂是甲基锂。

公开(公告)号：KR1020090090472A

公开(公告)日：2009-08-26

申请号：KR1020080015702

申请日：2008-02-21

Applicant: 덕성여자대학교 산학협력단

Inventor： 최은정 ,  이재인 ,  김건희

IPC: A61K31/35 ,  A61K31/352 ,  A61P35/00

Abstract: A composition for anticancer containing a flavanone derivative is provided to induce apoptosis of cancer cell and suppress cell proliferation by staying at G1 phase. A composition for anticancer comprises a flavanone derivative of the chemical formula 1. In the chemical formula 1, R1-R4 are hydrogen, C1-C4 alkyl group or C1-C4 alkoxy group. The cancer is selected among breast cancer, gastric cancer, lung cancer, brain cancer, skin cancer, uterine cancer, ovarian cancer, cancer of the rectum, perianal cancer, oviduct cancer, cancer of endometrium kind, uterine cervix cancer kind, vaginal cancer kind, vulvar carcinoma, hodgkin disease, esophageal cancer, norite, endocrine gland cancer, thyroid cancer, parathyroid cancer, hypernephroid carcinoma, soft tissue sarcoma, urethral carcinoma, penile cancer, prostate cancer, chronic, or the acute leukemia, lymphocyte lymphoma, bladder cancer, and extension, ureter cancer, renal cell carcinoma, kidney pelvis carcinoma, central nervous system tumor, first CNS lymphatic tumor, spinal cord tumor, brain stem gliomas and pituitary adenoma.

Abstract translation: 提供含有黄烷酮衍生物的抗癌剂组合物，以诱导癌细胞凋亡，并通过保持G1期抑制细胞增殖。 抗癌组合物包含化学式1的黄烷酮衍生物。在化学式1中，R 1 -R 4是氢，C 1 -C 4烷基或C 1 -C 4烷氧基。 癌症选自乳腺癌，胃癌，肺癌，脑癌，皮肤癌，子宫癌，卵巢癌，直肠癌，肛周癌，输卵管癌，子宫内膜癌，子宫颈癌，阴道癌类 ，外阴癌，霍奇金病，食管癌，诺里特，内分泌腺癌，甲状腺癌，甲状旁腺癌，肾上腺癌，软组织肉瘤，尿道癌，阴茎癌，前列腺癌，慢性或急性白血病，淋巴细胞淋巴瘤，膀胱癌 ，延伸，输尿管癌，肾细胞癌，肾盂癌，中枢神经系统肿瘤，第一CNS淋巴瘤，脊髓肿瘤，脑干胶质瘤和垂体腺瘤。

公开(公告)号：KR102212650B1

公开(公告)日：2021-02-05

申请号：KR1020190071275

申请日：2019-06-17

Applicant: 덕성여자대학교 산학협력단

Inventor： 이재인

IPC: C07D333/64

Abstract: 본발명의일 실시예는, 싸이오살리실산을강염기성물질및 벤질할라이드와반응시켜 2-(벤질싸이오)벤조산화합물을제조하는단계; 상기 2-(벤질싸이오)벤조산화합물을 N-메톡시-N-메틸카르바모일클로라이드와반응시켜 N-메톡시-N-메틸-2-(벤질싸이오)벤즈아마이드를제조하는단계; 상기 N-메톡시-N-메틸-2-(벤질싸이오)벤즈아마이드를아릴에틴일염으로처리하여 1-(2-벤질싸이오)페닐-3-페닐-2-프로핀-1-온을제조하는단계; 상기 1-(2-벤질싸이오)페닐-3-페닐-2-프로핀-1-온을산 물질로처리하는단계;를포함하는싸이오아우론계화합물의제조방법을제공한다.

公开(公告)号：KR101620158B1

公开(公告)日：2016-05-13

申请号：KR1020140028401

申请日：2014-03-11

Applicant: 덕성여자대학교 산학협력단

Inventor： 이재인 ,  송윤주 ,  최진선

IPC: C07D215/06 ,  C07D215/08

Abstract: 본발명은 2-할로벤조산으로부터 1-알킬-2-페닐-4-퀴놀론을제조하는신규한제조방법을제공한다. 본발명의제조방법은저렴한출발물질로서 2-할로벤조산을이용하여간단한반응조건및 단순화된단계를통해 1-알킬-2-페닐-4-퀴놀론을고수율로합성할수 있는장점이있다.

公开(公告)号：KR1020150106483A

公开(公告)日：2015-09-22

申请号：KR1020140028401

申请日：2014-03-11

Applicant: 덕성여자대학교 산학협력단

Inventor： 이재인 ,  송윤주 ,  최진선

IPC: C07D215/06 ,  C07D215/08

CPC classification number: C07D215/06 ,  C07D215/08

Abstract: 본 발명은 2-할로벤조산으로부터 1-알킬-2-페닐-4-퀴놀론을 제조하는 신규한 제조방법을 제공한다. 본 발명의 제조 방법은 저렴한 출발물질로서 2-할로벤조산을 이용하여 간단한 반응조건 및 단순화된 단계를 통해 1-알킬-2-페닐-4-퀴놀론을 고수율로 합성할 수 있는 장점이 있다.

Abstract translation: 提供了一种从2-卤代苯甲酸合成1-烷基-2-苯基-4-喹诺酮的新方法。 本发明的合成方法通过2-卤代苯甲酸酯作为廉价起始原料，在简单的反应条件下，通过简单的阶段，可以高收率合成1-烷基-2-苯基-4-喹诺酮。