Abstract:
본 발명은 피브린 표적 펩타이드 서열이 결합된 글라이콜 키토산-금 나노입자를 포함하는 혈전 탐지용 CT 조영제에 관한 것이다. 본 발명에 따른 혈전 탐지용 CT 조영제는 심뇌혈관 혈전증에서 혈전의 크기 및 위치에 관한 CT 영상 정보를 신속, 반복적으로 획득할 수 있게 하고, 뇌혈전의 영상 모니터링도 가능하게 한다.
Abstract:
The present invention relates to a CT contrast agent for detecting blood clot containing a fibrin target peptide sequence conjugated glycol chitosan-gold nanoparticle. The a CT contrast agent for detecting blood clot enables users to rapidly and repeatedly obtain CT image information of the size and the location of the blood clot in cardio-cerebrovascular thrombosis, and to monitor images of cerebral thrombosis.
Abstract:
PURPOSE: A CT(Computed Tomography)-based monitoring method customized to an individual thrombus using a gold nanoparticle for optimizing determination of thrombolytic drug dosage is provided to obtain a CT image informing size and location of a thrombus, thereby noninvasively monitoring a thrombus not sacrificing experimented animals. CONSTITUTION: A gold nanoparticle coated with glycol chitosan is injected into an animal. The gold nanoparticle coated with glycol chitosan is made from reaction between glycol chitosan solution and gold chloride solution. A CT image is obtained by a micro CT. The CT image is reconstructed into a 3D(Three Dimensional) image using software.